Curcumin blocks CCL2-induced adhesion, motility and invasion, in part, through down-regulation of CCL2 expression and proteolytic activity

International Journal of Oncology

Volumn 34, Issue 5, 2009, Pages 1319-1327

  Herman, Jeffery G ^a   Stadelman, Henry L ^a   Roselli, Charles E ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

CCL2; Diet; MCP 1; Nutrition; PKC; Prostate cancer

Indexed keywords

COLLAGEN; CURCUMIN; GELATINASE B; LAMININ; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN KINASE C ACTIVATOR;

ARTICLE; CANCER CELL CULTURE; CELL ADHESION; CELL INVASION; CELL MOTILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MALE; METASTASIS INHIBITION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

CELL ADHESION; CELL MOVEMENT; CHEMOKINE CCL2; CURCUMIN; DOWN-REGULATION; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MATRIX METALLOPROTEINASE 9; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; PROSTATIC NEOPLASMS; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; TUMOR CELLS, CULTURED;

EID: 67649523505     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000259     Document Type: Article

References (42)

1. Bubendorf L, Schopfer A, Wagner U, et al: Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients. Hum Pathol 31: 578-583, 2000.
2. Bussard KM, Gay CV and Mastro AM: The bone microenvironment in metastasis; what is special about bone? Cancer Metastasis Rev 27: 41-55, 2008.
3. Ye L, Kynaston HG and Jiang WG: Bone metastasis in prostate cancer: molecular and cellular mechanisms (Review). Int J Mol Med 20: 103-111, 2007.
4. Craig MJ and Loberg RD: CCL2 (monocyte chemoattractant protein-1) in cancer bone metastases. Cancer Metastasis Rev 25: 611-619, 2006.
5. Lu Y, Xiao G, Galson DL, et al: PTHrP-induced MCP-1 production by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation and prostate cancer cell proliferation and invasion in vitro. Int J Cancer 121: 724-733, 2007.
6. Lu Y, Cai Z, Galson DL, et al: Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion. Prostate 66: 1311-1318, 2006.
7. Luster AD: Chemokines-chemotactic cytokines that mediate inflammation. N Engl J Med 338: 436-445, 1998.
8. Loberg RD, Tantivejkul K, Craig M, Neeley CK and Pienta KJ: PAR1-mediated RhoA activation facilitates CCL2-induced chemotaxis in PC-3 cells. J Cell Biochem 101: 1292-1300, 2007.
9. Lu Y, Cai Z, Xiao G, Liu Y, Keller ET, Yao Z and Zhang J: CCR2 expression correlates with prostate cancer progression. J Cell Biochem 101: 676-685, 2007.
10. Sharma RA, Gescher AJ and Steward WP: Curcumin: the story so far. Eur J Cancer 41: 1955-1968, 2005.
11. Hsing AW, Tsao L and Devesa SS: International trends and patterns of prostate cancer incidence and mortality. Int J Cancer 85: 60-67, 2000.
12. Quinn M and Babb P: Patterns and trends in prostate cancer incidence, survival, prevalence and mortality. Part I: international comparisons. BJU Int 90: 162-173, 2002.
13. Dorai T, Gehani N and Katz A: Therapeutic potential of curcumin in human prostate cancer-I. curcumin induces apoptosis in both androgen-dependent and androgen-independent prostate cancer cells. Prostate Cancer Prostatic Dis 3: 84-93, 2000.
14. Takahara N, Kashiwagi A, Maegawa H and Shigeta Y: Lysophosphatidylcholine stimulates the expression and production of MCP-1 by human vascular endothelial cells. Metabolism 45: 559-564, 1996.
15. Wang G, Siow YL and O K: Homocysteine stimulates nuclear factor kappaB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: a possible role for protein kinase C. Biochem J 352: 817-826, 2000.
16. Wu Y, Wu G, Qi X, Lin H, Qian H, Shen J and Lin S: Protein kinase C beta inhibitor LY333531 attenuates intercellular adhesion molecule-1 and monocyte chemotactic protein-1 expression in the kidney in diabetic rats. J Pharmacol Sci 101: 335-343, 2006.
17. Herman JG and Meadows GG: Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells. Int J Oncol 30: 1231-1238, 2007.
18. Chua PK, Melish ME, Yu Q, Yanagihara R, Yamamoto KS and Nerurkar VR: Elevated levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 during the acute phase of Kawasaki disease. Clin Diagn Lab Immunol 10: 308-314, 2003.
19. Hong JH, Ahn KS, Bae E, Jeon SS and Choi HY: The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo. Prostate Cancer Prostatic Dis 9: 147-152, 2006.
20. Khar A, Ali AM, Pardhasaradhi BV, Varalakshmi CH, Anjum R and Kumari AL: Induction of stress response renders human tumor cell lines resistant to curcumin-mediated apoptosis: role of reactive oxygen intermediates. Cell Stress Chaperones 6: 368-376, 2001.
21. Kim SJ and Hellerstein MK: Pharmacological doses of dietary curcumin increase colon epithelial cell proliferation in vivo in rats. Phytother Res 21: 995-998, 2007.
22. Loberg RD, Ying C, Craig M, et al: Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate cancer tumor regression in vivo. Cancer Res 67: 9417-9424, 2007.
23. Kim YS, Ahn Y, Hong MH, et al: Curcumin attenuates inflammatory responses of TNF-alpha-stimulated human endothelial cells. J Cardiovasc Pharmacol 50: 41-49, 2007.
24. Amoli MM, Mousavizadeh R, Sorouri R, Rahmani M and Larijani B: Curcumin inhibits in vitro MCP-1 release from mouse pancreatic islets. Transplant Proc 38: 3035-3038, 2006.
25. Kumar MA and Krishna M: In vivo modulation of signaling factors involved in cell survival. J Radiat Res 45: 491-495, 2004.
26. Zen K, Masuda J, Sasaguri T, Kosaka C and Ogata J: Gene expression of monocyte chemoattractant protein-1 in human monocytes is regulated by cell density through protein tyrosine kinase and protein kinase C. Exp Cell Res 215: 172-179, 1994.
27. Porreca E, Di Febbo C, Reale M, et al: Monocyte chemotactic protein 1 (MCP-1) is a mitogen for cultured rat vascular smooth muscle cells. J Vasc Res 34: 58-65, 1997.
28. Carnevale KA and Cathcart MK: Protein kinase C beta is required for human monocyte chemotaxis to MCP-1. J Biol Chem 278: 25317-25322, 2003.
29. Pai R, Ha H, Kirschenbaum MA and Kamanna VS: Role of tumor necrosis factor-alpha on mesangial cell MCP-1 expression and monocyte migration: mechanisms mediated by signal transduction. J Am Soc Nephrol 7: 914-923, 1996.
30. Lin WW and Chen BC: Distinct PKC isoforms mediate the activation of cPLA2 and adenylyl cyclase by phorbol ester in RAW264.7 macrophages. Br J Pharmacol 125: 1601-1609, 1998.
31. Szijgyarto Z, Szucs K, Kovacs I, Zakany R, Sipka S and Gergely P: The role of protein kinase C isoenzymes in the regulation of calcineurin activity in human peripheral blood mononuclear cells. Int J Mol Med 20: 359-364, 2007.
32. Koivunen J, Aaltonen V, Koskela S, Lehenkari P, Laato M and Peltonen J: Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells. Cancer Res 64: 5693-5701, 2004.
33. Orlichenko LS and Radisky DC: Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development. Clin Exp Metastasis 25: 593-600, 2008.
34. Eugenin EA, Osiecki K, Lopez L, Goldstein H, Calderon TM and Berman JW: CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS. J Neurosci 26: 1098-1106, 2006.
35. Okuma T, Terasaki Y, Kaikita K, Kobayashi H, Kuziel WA, Kawasuji M and Takeya M: C-C chemokine receptor 2 (CCR2) deficiency improves bleomycin-induced pulmonary fibrosis by attenuation of both macrophage infiltration and production of macrophage-derived matrix metalloproteinases. J Pathol 204: 594-604, 2004.
36. Woo MS, Jung SH, Kim SY, Hyun JW, Ko KH, Kim WK and Kim HS: Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells. Biochem Biophys Res Commun 335: 1017-1025, 2005.
37. Ishizuka T, Sawada S, Sugama K and Kurita A: Thromboxane A2 (TXA2) receptor blockade suppresses monocyte chemoattractant protein-1 (MCP-1) expression by stimulated vascular endothelial cells. Clin Exp Immunol 120: 71-78, 2000.
38. Shankar S, Ganapathy S, Chen Q and Srivastava RK: Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis. Mol Cancer 7: 16, 2008.
39. Lin CW, Hou WC, Shen SC, Juan SH, Ko CH, Wang LM and Chen YC: Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/ AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells. Carcinogenesis 29: 1807-1815, 2008.
40. Himelstein BP, Lee EJ, Sato H, Seiki M and Muschel RJ: Transcriptional activation of the matrix metalloproteinase-9 gene in an H-ras and v-myc transformed rat embryo cell line. Oncogene 14: 1995-1998, 1997.
41. Di Giulio C, Rapino M, Zingariello M, Antonucci A and Cataldi A: PKC alpha-mediated CREB activation is oxygen and age-dependent in rat myocardial tissue. Histochem Cell Biol 127: 327-333, 2007.
42. Chen Y, Shu W, Chen W, Wu Q, Liu H and Cui G: Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells. Basic Clin Pharmacol Toxicol 101: 427-433, 2007.