In vivo modulation of signaling factors involved in cell survival

Journal of Radiation Research

Volumn 45, Issue 4, 2004, Pages 491-495

  Kumar Mitra, Anirban ^a   Krishna, Malini ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

ERK; NF B; PKC; Radiation and fibrosarcoma

Indexed keywords

AMIDES; CELL SIGNALING; IRRADIATION; MODULATION;

CELL SURVIVAL; CURCUMIN; ERK; IN-VIVO; ISOFORMS; NF-ΚB; NUCLEAR FACTORS; PROTEIN KINASES C; RADIATION AND FIBROSARCOMA; RADIORESISTANCE;

RADIOTHERAPY;

CURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE; PROTEIN KINASE C; RUTOSIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL KILLING; CELL SURVIVAL; CONTROLLED STUDY; ENZYME INHIBITION; FIBROSARCOMA; GAMMA IRRADIATION; GENE TRANSLOCATION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RADIOSENSITIVITY; TUMOR CELL;

ANIMALIA;

EID: 13844271912     PISSN: 04493060     EISSN: None     Source Type: Journal    
DOI: 10.1269/jrr.45.491     Document Type: Article

References (19)

1. Schmidt-Ullrich, R. K., Dent, P., Grant, S., Mikkelson R. B. and Valerie, K. (2000). Signal transduction and cellular radiation responses. Radiat. Res. 153: 245-257.
2. th Ed., J.B. Lippincott Co., Philadelphia.
3. Varadkar, P., Krishna, M. and Verma, N. C. (2001). Alterations in hepatic kinase activity following whole body γ-irradiation of mice. Antioxidants and Redox Signaling. 3: 483-492.
4. Wang, C. Y., Mayo M. W. and Baldwin Jr., A. S. (1996). TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NFκB. Science 274: 784-787.
5. Chimura, S. J., Mauceri H. J., Advani S. R., Heimann, R., Beckett, M. A., Nodzenski, E., Quintans, J., Kufe, D. W. and Weichselbaum, R. R. (1997). Decreasing the apoptotic threshold of tumour cells through protein kinase C inhibition and sphingomyelinase activation increases tumour killing by ionising radiation. Cancer Res 57: 4340-4347.
6. Cartee, L., Vrana, J. A., Wang, Z., Park, J. S., Birrer, M., Fisher, P. B., Grant, S. and Dent P. (2000). Inhibition of the mitogen activated protein kinase pathway potentiates radiation-induced cell killing via cell cycle arrest at the G2/M transition and independently of increased signaling by the JNK/c-Jun pathway. Int J Oncol. 16: 413-422.
7. Kuabara, M., Takahashi, K. and Inanami, O. (2003). Induction of apoptosis through the activation of SAPK/JNK followed by the expression of death receptor Fas in X-irradiated cells. J. Radiat. Res. 44: 203-209.
8. Honda, N., Yagi, K., Ding, G. R. and Miyakoshi, J. (2002). Radiosensitization by overexpression of the nonphosphorylation form of IκB-α in human glioma cells. Journal of Radiat. Res. 43: 283-292.
9. Takahashi, I., Kobayashi, E., Asano, K., Yoshida, M. and Nakano, H. (1987). A selective inhibitor of protein kinase C from streptomyces. J Antibiot (Tokyo) 40: 1782-1784.
10. English, J. M. and Cobb, M. H. (2002). Pharmacological inhibitors of MAPK pathways. Trends Phrmacol Sci 23, 40-45.
11. Simon, A., Allais, D. P., Duroux, J. L., Basly, J. P., Durand-Fontanier, S., and Delage, C. (1998). Inhibitory effect of curcuminoids on MCF-7 cell proliferation and structure-activity relationships. Cancer Letters 129: 111-116.
12. Lui, J. Y., Lin S.J. and Lin, J. K. (1993). Inhibitory effects of curcumin on protein kinase C activity induced by 12-O- tetradecanoylphorbol-13- acetate in NIH 3T3 cells. Carcinogenesis 14: 857-861.
13. Varadkar, P., Dubey, P., Krishna, M., and Verma, N. C. (2001). Modulation of radiation-induced protein kinase C activity by phenolics. J Radiol Prot 21: 361-370.
14. Waravdekar, S. S. and Ranadive, K. J. (1957). Biological testing of sulphur isosteres of carcinogenic hydrocarbons. J Natl Cancer Inst 18: 555-559.
15. Balasubramanian, N., Advani S. H. and Zingde, S. M. (1998). Protein kinase C isoforms in normal and chronic myeloid leukemic neutrophils. Distinct signal for PKC α by immunodetection on PVDF membrane, decreased expression of PKC _ and increased expression of PKC δ in leukemic neutrophils. Leukaemia Res 22: 597-604.
16. Lowry, O. H., Rosebrough, N. S., Farr A. L., Randall, R. J. (1951). Protein measurement with Folin phenol reagent. J Biol Chem 193: 265-275.
17. Han, Y., Meng, T., Murray N. R., Fields, A. P., and Brasier, A. R. (1999). Interlukin-1-induced Nuclear Factor-κB-IκBα autoregulatory feedback loop in hepatocytes. J Biol Chem 274: 939-947.
18. Jones, P. L., Ping, D. and Boss, J. M. (1997). Tumour necrosis factor α and interlukin-1β regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EPB-β and NFκB. Mol Cell Biol 17: 6970-6981.
19. Hwang, S. and Ding, A. (1995). Activation of NFκB in murine macrophages by taxol. Cancer Biochem Biophys 14: 265-272.