Distinct PKC isoforms mediate the activation of cPLA2 and adenylyl cyclase by phorbol ester in RAW264.7 macrophages

British Journal of Pharmacology

Volumn 125, Issue 7, 1998, Pages 1601-1609

  Lin, Wan W ^a   Chen, Bin C ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Adenylyl cyclase; cPLA2; PKC isoform; RAW 264.7; Signalling crosstalk

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; ADENYLATE CYCLASE; ARACHIDONIC ACID; CYCLIC AMP; IONOMYCIN; LY 379196; PHORBOL ESTER; PHOSPHOLIPASE A2; PROSTAGLANDIN E1; PROTEIN KINASE C; STAUROSPORINE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; IMMUNOBLOTTING; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031792203     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702219     Document Type: Article

References (48)

1. BALBOA, M.A., FIRESTEIN, B.L., GODSON, C., BELL, K.S. & INSEL, P.A. (1994). Protein kinase Cα mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby canine kidney cells. J. Biol. Chem., 269, 10511-10516.
2. BERG, K.A., CLARKE, W.P., CHEN, Y., EBERSOLE, B.J., MCKAY, R.O.G. & MAAYANI, S. (1994). 5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms. Mol. Pharmacol., 45, 826-836.
3. CHOI, E.J., WONG, S.T., DITTMAN, A.H. & STORM, D.R. (1993). Phorbol ester stimulation of the type I and type II adenylyl cyclases in whole cells. Biochemistry, 32, 1891-1894.
4. DEKKER, L.V. & PARKER, P.J. (1994). Protein kinase C a question of specificity. Trends Biochem. Sci., 19, 73-77.
5. 2 superfamily of signal transduction enzymes. Trends Biochem. Sci., 22, 1-2.
6. DENT, G. & RABE, K (1996). Effect of theophylline and non-selective xanthine derivatives on PDE isozymes and cellular function. In Phosphodiesterase inhibitors, ed. Schudt, C., Dent, G., Rabe, K.F. pp. 41-65. Academic Press.
7. DUDLEY, D.T., PANG, L., DECKER, S.J., BRIDGES, A.J. & SALTIEL, A.R. (1995). A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. U.S.A., 92, 7686-7689.
8. DUYSTER, J., SCHWENDE, H., FITZKE, E., HIDAKA, H. & DIETER, P. (1993). Different roles of protein kinase C-β and -δ in arachidonic acid cascade, superoxide formation and phosphoinositide hydrolysis. Biochem. J., 292, 203-207.
9. FERBY, I.M., WAGA, I., SAKANAKA, C., KUME, K. & SHIMIZU, T. (1994). Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea-pig neutrophils. J. Biol. Chem., 269, 30485-30488.
10. GODSON, C., BELL, K.S. & INSEL, P.A. (1993). Inhibition of expression of protein kinase Cα by antisense cDNA inhibits phorbol ester-mediated arachidonate release. J. Biol. Chem., 268, 11946-11950.
11. GUSOVSKY, F. & GUTKIND, J.S. (1991). Selective effects of activation of protein kinase C isozymes on cyclic AMP accumulation. Mol. Pharmacol., 39, 124-129.
12. 2+, protein kinase C, and protein kinase A in hormonal stimulation of phospholipase D in rat hepatocytes. J. Biol. Chem., 269, 849-859.
13. HA, K.S. & EXTON, J.H. (1993). Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor. J. Biol. Chem., 268, 10534-10539.
14. HUG, H. & SARRE, T.F. (1993). Protein kinase C isoenzymes: divergence in signal transduction? Biochem. J., 291, 329-343.
15. JACOBOWITZ, O., CHEN, J., PREMONT, R.T. & IYENGAR, R. (1993). Stimulation of specific types of Gs-stimulated adenylyl cyclases by phorbol ester treatment. J. Biol. Chem., 268, 3829-3832.
16. JACOBOWITZ, O. & IYENGAR, R. (1994). Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2. Proc. Natl. Acad. Sci. U.S.A., 91, 10630-10634.
17. JAKEN, S. (1996). Protein kinase C isozymes and substrates. Curr. Opin. Cell Biol., 8, 168-173.
18. 2 activity in bovine rod outer segment by the βγ subunit of transducin and its inhibition by the a subunit. Proc. Natl. Acad. Sci. U.S.A., 84, 3625-3630.
19. KANAHO, Y., TAKAHASHI, K, TOMITA, U., HRI, T., KATADA, T., UI, M. & NOZAWA, Y. (1992). A protein kinase C inhibitor, staurosporine, activates phospholipase C via a pertussis toxin-sensitive GTP-binding protein in rabbit peritoneal neutrophils. J. Biol. Chem., 267, 23554-23559.
20. KAWABE, J., IWAMI, G., EBINA, T., OHNO, S., KATADA, T., UEDA, Y., HOMCY, C.J. & ISHIKAWA, Y. (1994). Differential activation of adenylyl cyclase by protein kinase C isoenzymcs. J. Biol. Chem., 269, 16554-16558.
21. KAWABE, J., EBINA, T., TOYA, Y., OKA, N., SCHWENCKE, C., DUZIC, E. & ISHIKAWA, Y. (1996). Regulation of type V adenylyl cyclase by PMA-sensitive and -insensitive protein kinase C isoenzymes in intact cells. FEBS Lett., 384, 273-276.
22. LAI, H.-L., YANG, T.-H., MESSING, R.O., CHING, Y.-H., LIN, S.-C. & CHERN, Y. (1997). Protein kinase C inhibits adenylyl cyclase type V1 activity during desensitization of the A2a-adenosine receptor-mediated cyclic AMP response. J. Biol. Chem., 272, 4970-4977.
23. 2 in RAW 264.7 macrophages. Br. J. Pharmacol., 119, 261-268.
24. LIN, W.W. & CHEN, B.C. (1997). Involvement of protein kinase C in the UTP-mediated potentiation of cyclic AMP accumulation in mouse J774 macrophages. Br. J. Pharmacol., 121, 1749-1757.
25. LIN, W.W. (1997). Priming effects of lipopolysaccharide on UTP-induced arachidonic acid release in RAW 264.7 macrophages. Eur. J. Pharmacol., 321, 121-127.
26. LIN, W.W. & CHEN, B.C. (1998). Pharmacological comparison of UTP- and thapsigargin-induced arachidonic acid release in mouse RAW 264.7 macrophages. Br. J. Pharmacol., 123, 1173-1181.
27. LUSTIG, K.D., CONKLIN, B.R., HERZMARK, P., TAUSSIG, R. & BOURNE, H.R. (1993). Type H adenylyl cyclase integrates coincident signals from Gs, Gi and Gq. J. Biol. Chem., 268, 13900-13905.
28. MARTINY-BARON, G., KAZANIETZ, M.G., MISCHAK, H., BLUMBERG, P.M., KOCHS, G., HUG, H., MARME, D. & SCHACHTELE, C. (1993). Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J. Biol. Chem., 268, 9194-9197.
29. MULLER, G., AYOUB, M., STORZ, P., RENNECKE, J., FABBRO, D. & PFIZENMAIER, K. (1995). PKCξ is a molecular switch in signal transduction of TNFα, bifunctionally regulated by ceramide and arachidonic acid. EMBO J., 14, 1961-1969.
30. NAKANISHI, S., KAKITA, S., TAKAHASHI, I., KAWAHARA, K., TSUKUDA, E., SANO, T., YAMADA, K., YOSHIDA, M., KASE H. & MATSUDA, Y. (1992). Wortmannin, a microbial product inhibitor of myosin light chain kinase. J. Biol. Chem., 267, 2157-2163.
31. NAKANISHI, H., BREWER, K. & EXTON, J.H. (1993). Activation of the ξ isozyme to protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem., 268, 13-16.
32. NAKANISHI, S., CATT, K. & BALLA, T. (1995). A wortmannin-sensitive phosphatidylinositol 4-kinase thai regulates hormone-sensitive pools of inositolphospholipids. Proc. Nutl. Acad. Sci. U.S.A., 92, 5317-5321.
33. NISHIZUKA, Y. (1995). Protein kinase C and lipid signaling for sustained cellular responses. FASEB J., 9, 484-496.
34. PAVLOVIC-SURJANCEV, B., CAHILL, A.L. & PERLMAN, R.L. (1993). Staurosporine activates a 60,000 Mr protein kinase in bovine chromaffin cells that phosphorylales myelin basic protein in vitro. J. Neurochem., 61, 697-703.
35. 2. J. Biol. Chem., 269, 19480-19487.
36. RZYMKIEWICZ, D.M., TETSUKA, T., DAPHNA-IKEN, D., SRIVASTAVA, S. & MORRISON, A.R. (1996). Interleukin-1β activates protein kinase Cξ in renal mesangial cells. J. Biol. Chem., 271, 17241-17246.
37. SERHAN, C.N., HAEGGSTROM, J.Z. & LESLIE, C.C. (1996). Lipid mediator networks in cell signaling: update and impact of cytokines. FASEB J., 10, 1147-1158.
38. SUNAHARA, R.K., DESSAUER, C.W. & GILMAN, A.G. (1996). Complexity and diversity of mammalian adenylyl cyclases. Ann. Rev. Pharmacol. Toxicol., 36, 461-480.
39. TAYLOR, D.J., EVANSON, J.M. & WOOLLEY, D.E. (1990). Contrasting effects of the protein kinase C inhibitor, Staurosporine, on cytokine and phorbol ester stimulation of fructose 2.6-bisphosphate and prostaglandin E production by fibroblasts in vitro. Biochem. J., 269, 573-577.
40. TAUSSIG, R. & GILMAN, A.G. (1995). Mammalian membrane-bound adenylyl cyclases. J. Biol. Chem., 270, 1-4.
41. THOMPSON, N.T., BONSER, R. & GARLAND, L.G. (1991). Receptor-coupled phospholipase D and its inhibition. Trends Pharmacol. Sci., 12, 404-408.
42. TSU, R.C. & WONG, Y.H. (1996). Gi-mediated stimulation of type II adenylyl cyclase is augmented by Gq-coupled receptor activation and phorbol ester treatment. J. Neurosci., 16, 1317-1323.
43. UI, M., OKADA, T., HAZEKI, K. & HAZEKI, O (1995). Wortmannin as an unique probe for an intracellular signaling protein, phopsphoinositide 3-kinase. Trends Biochem. Sci., 20, 303-307.
44. 2 in mouse spleen and the macrophage cell line J774. Purification, substrate interaction and phosphorylation by protein kinase C. Eu. J. Biochem., 202, 873-880.
45. 2 and mitogen-activated protein kinase by alpha 1-adrenergic receptors in Madin-Darby canine kidney cells. J. Clin. Invest., 97, 1302-1310.
46. YOUNG, S., PARKER, P., ULLRICH, A. & STABEL, S. (1987). Down-regulation of protein kinase C is due to an increased rate of degradation. Biochem. J., 244, 775-779.
47. ZHOU, X.-M., CURRAN, P., BAUMGOLD, J. & FISHMAN, P.H. (1994). Modulation of adenylylcyclase by protein kinase C in human neurotumor SK-N-MC cells: evidence that the α isozyme mediates both potentiation and desensitization. J. Neurochem., 63, 1361-1370.
48. ZIMMERMANN, G. & TAUSSIG, R. (1996). Protein kinase C alters the responsiveness of adenylyl cyclases to G protein α and βγ subunits. J. Biol. Chem., 271, 27161-27166.