Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat

Physiological Genomics

Volumn 31, Issue 2, 2007, Pages 228-235

  Moreno, Carol ^a   Kaldunski, Mary L ^a   Wang, Tao ^a   Roman, Richard J ^a   Greene, Andrew S ^a   Lazar, Jozef ^a   Jacob, Howard J ^a   Cowley Jr , Allen W ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Congenic strain; Consomic strain; Genetic epistasis; Linkage; Quantitative trait loci

Indexed keywords

SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE MEASUREMENT; CHROMOSOME 13; CONGENIC STRAIN; CONTROLLED STUDY; FEMALE; GENE LOCUS; HIGH SODIUM INTAKE; HYPERTENSION; KIDNEY INJURY; MALE; MICROALBUMINURIA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SEX DIFFERENCE;

ALBUMINURIA; ANIMALS; ANIMALS, CONGENIC; BLOOD PRESSURE; CHROMOSOME MAPPING; EPISTASIS, GENETIC; FEMALE; GENOTYPE; HYPERTENSION; MALE; PHENOTYPE; RATS; RATS, INBRED BN; RATS, INBRED DAHL; SEX CHARACTERISTICS; SODIUM CHLORIDE, DIETARY;

RATTUS;

EID: 35548972551     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00280.2006     Document Type: Article

References (48)

1. Ahmad U, Saleheen D, Bokhari A, Frossard PM. Strong association of a renin intronic dimorphism with essential hypertension. Hypertens Res 28: 339-344, 2005.
2. Belknap JK. Chromosome substitution strains: some quantitative considerations for genome scans and fine mapping. Mamm Genome 14: 723-732, 2003.
3. Campese VM. Salt sensitivity in hypertension. Renal and cardiovascular implications. Hypertension 23: 531-550, 1994.
4. Charron S, Duong C, Menard A, Roy J, Eliopoulos V, Lambert R, Deng AY. Epistasis, not numbers, regulates functions of clustered Dahl rat quantitative trait loci applicable to human hypertension. Hypertension 46: 1300-1308, 2005.
5. Clark JS, Jeffs B, Davidson AO, Lee WK, Anderson NH, Bihoreau MT, Brosnan MJ, Devlin AM, Kelman AW, Lindpaintner K, Dominiczak AF. Quantitative trait loci in genetically hypertensive rats. Possible sex specificity. Hypertension 28: 898-906, 1996.
6. Cowley AW Jr, Roman RJ, Kaldunski ML, Dumas P, Dickhout JG, Greene AS, Jacob HJ. Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat. Hypertension 37: 456-461, 2001.
7. Deng Y, Rapp JP. Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Nat Genet 1: 267-272, 1992.
8. DiPaola NR, Rapp JP, Brand PH, Beierwaltes WH, Metting PJ, Britton SL. Evaluation of the renin-angiotensin system in a congenic renin Dahl salt-sensitive rat. Genes Funct 1: 215-226, 1997.
9. Don RH, Cox PT, Wainwright BJ, Baker K, Mattick JS. "Touchdown" PCR to circumvent spurious priming during gene amplification. Nucleic Acids Res 19: 4008, 1991.
10. Dubay C, Vincent M, Samani NJ, Hilbert P, Kaiser MA, Beressi JP, Kotelevtsev Y, Beckmann JS, Soubrier F, Sassard J, Lathrop GM. Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats. Nat Genet 3: 354-357, 1993.
11. Dutil J, Eliopoulos V, Tremblay J, Hamet P, Charron S, Deng AY. Multiple quantitative trait loci for blood pressure interacting epistatically and additively on Dahl rat chromosome 2. Hypertension 45: 557-564, 2005.
12. Frossard PM, Lestringant GG, Malloy MJ, Kane JP. Human renin gene BglI dimorphism associated with hypertension in two independent populations. Clin Genet 56: 428-433, 1999.
13. Grim CE, Wilson TW, Nicholson GD, Hassell TA, Fraser HS, Grim CM, Wilson DM. Blood pressure in blacks. Twin studies in Barbados. Hypertension 15: 803-809, 1990.
14. Hamet P, Merlo E, Seda O, Broeckel U, Tremblay J, Kaldunski M, Gaudet D, Bouchard G, Deslauriers B, Gagnon F, Antoniol G, Pausova Z, Labuda M, Jomphe M, Gossard F, Tremblay G, Kirova R, Tonellato P, Orlov SN, Pintos J, Platko J, Hudson TJ, Rioux JD, Kotchen TA, Cowley AW Jr. Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension. Am J Hum Genet 76: 815-832, 2005.
15. Jiang J, Stec DE, Drummond H, Simon JS, Koike G, Jacob HJ, Roman RJ. Transfer of a salt-resistant renin allele raises blood pressure in Dahl salt-sensitive rats. Hypertension 29: 619-627, 1997.
16. Kotchen TA, Zhang HY, Covelli M, Blehschmidt N. Insulin resistance and blood pressure in Dahl rats and in one-kidney, one-clip hypertensive rats. Am J Physiol Endocrinol Metab 261: E692-E697, 1991.
17. Kovacs P, Voigt B, Kloting I. Alleles of the spontaneously hypertensive rat decrease blood pressure at loci on chromosomes 4 and 13. Biochem Biophys Res Commun 238: 586-589, 1997.
18. Kristjansson K, Manolescu A, Kristinsson A, Hardarson T, Knudsen H, Ingason S, Thorleifsson G, Frigge ML, Kong A, Gulcher JR, Stefansson K. Linkage of essential hypertension to chromosome 18q. Hypertension 39: 1044-1049, 2002.
19. Krushkal J, Ferrell R, Mockrin SC, Turner ST, Sing CF, Boerwinkle E. Genome-wide linkage analyses of systolic blood pressure using highly discordant siblings. Circulation 99: 1407-1410, 1999.
20. Kurtz TW, Simonet L, Kabra PM, Wolfe S, Chan L, Hjelle BL. Cosegregation of the renin allele of the spontaneously hypertensive rat with an increase in blood pressure. J Clin Invest 85: 1328-1332, 1990.
21. Kwitek-Black AE, Jacob HJ. The use of designer rats in the genetic dissection of hypertension. Curr Hypertens Rep 3: 12-18, 2001.
22. Lalouel JM. Large-scale search for genes predisposing to essential hypertension. Am J Hypertens 16: 163-166, 2003.
23. Lee WK, Padmanabhan S, Dominiczak AF. Genetics of hypertension: from experimental models to clinical applications. J Hum Hypertens 14: 631-647, 2000.
24. Mansfield TA, Simon DB, Farfel Z, Bia M, Tucci JR, Lebel M, Gutkin M, Vialettes B, Christofilis MA, Kauppinen-Makelin R, Mayan H, Risch N, Lifton RP. Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21. Nat Genet 16: 202-205, 1997.
25. Monti J, Plehm R, Schulz H, Ganten D, Kreutz R, Hubner N. Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10. Hum Mol Genet 12: 435-439, 2003.
26. Moore JH. The ubiquitous nature of epistasis in determining susceptibility to common human diseases. Hum Hered 56: 73-82, 2003.
27. Moreno C, Dumas P, Kaldunski ML, Tonellato PJ, Greene AS, Roman RJ, Cheng Q, Wang Z, Jacob HJ, Cowley AW Jr. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Physiol Genomics 15: 243-257, 2003.
28. Moreno C, Kennedy K, Andrae JW, Jacob HJ. Genome-Wide Scanning With SSLPs in the Rat. In: Hypertension: Methods and Protocols, edited by Fennell JP and Baker AH. Totowa, NJ: Humana, 2005, p. 131-138.
29. Morrison AC, Cooper R, Hunt S, Lewis CE, Luke A, Mosley TH, Boerwinkle E. Genome scan for hypertension in nonobese African Americans: the National Heart, Lung, and Blood Institute Family Blood Pressure Program. Am J Hypertens 17: 834-838, 2004.
30. O'Donnell CJ, Lindpaintner K, Larson MG, Rao VS, Ordovas JM, Schaefer EJ, Myers RH, Levy D. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation 97: 1766-1772, 1998.
31. Palijan A, Dutil J, Deng AY. Quantitative trait loci with opposing blood pressure effects demonstrating epistasis on Dahl rat chromosome 3. Physiol Genomics 15: 1-8, 2003.
32. Pankow JS, Rose KM, Oberman A, Hunt SC, Atwood LD, Djousse L, Province MA, Rao DC. Possible locus on chromosome 18q influencing postural systolic blood pressure changes. Hypertension 36: 471-476, 2000.
33. Pravenec M, Simonet L, Kren V, Kunes J, Levan G, Szpirer J, Szpirer C, Kurtz T. The rat renin gene: assignment to chromosome 13 and linkage to the regulation of blood pressure. Genomics 9: 466-472, 1991.
34. Rapp JP. Genetic analysis of inherited hypertension in the rat. Physiol Rev 80: 135-172, 2000.
35. Rapp JP, Garrett MR, Deng AY. Construction of a double congenic strain to prove an epistatic interaction on blood pressure between rat chromosomes 2 and 10. J Clin Invest 101: 1591-1595, 1998.
36. Rapp JP, Wang SM, Dene H. A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure. Science 243: 542-544, 1989.
37. Rice T, Rankinen T, Chagnon YC, Province MA, Perusse L, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. Genomewide linkage scan of resting blood pressure: HERITAGE Family Study. Health, risk factors, exercise training, and genetics. Hypertension 39: 1037-1043, 2002.
38. Rice T, Rankinen T, Province MA, Chagnon YC, Perusse L, Borecki IB, Bouchard C, Rao DC. Genome-wide linkage analysis of systolic and diastolic blood pressure: the Quebec Family Study. Circulation 102: 1956-1963, 2000.
39. Samani NJ, Gauguier D, Vincent M, Kaiser MA, Bihoreau MT, Lodwick D, Wallis R, Parent V, Kimber P, Rattray F, Thompson JR, Sassard J, Lathrop M. Analysis of quantitative trait loci for blood pressure on rat chromosomes 2 and 13. Age-related differences in effect. Hypertension 28: 1118-1122, 1996.
40. St. Lezin EM, Pravenec M, Wong AL, Liu W, Wang N, Lu S, Jacob HJ, Roman RJ, Stec DE, Wang JM, Reid IA, Kurtz TW. Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. J Clin Invest 97: 522-527, 1996.
41. Stoll M, Cowley AW Jr, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Schork NJ, Wang Z, Jacob HJ. A genomic-systems biology map for cardiovascular function. Science 294: 1723-1726, 2001.
42. Stoll M, Jacob HJ. Genetic rat models of hypertension: relationship to human hypertension. Curr Hypertens Rep 3: 157-164, 2001.
43. Stoll M, Kwitek-Black AE, Cowley AW Jr, Harris EL, Harrap SB, Krieger JE, Printz MP, Provoost AP, Sassard J, Jacob HJ. New target regions for human hypertension via comparative genomics. Genome Res 10: 473-482, 2000.
44. Twigger SN, Nie J, Ruotti V, Yu J, Chen D, Li D, Mathis J, Narayanasamy V, Gopinath GR, Pasko D, Shimoyama M, De La Cruz N, Bromberg S, Kwitek AE, Jacob HJ, Tonellato PJ. Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human data. Genome Res 14: 651-660, 2004.
45. Weiss LA, Pan L, Abney M, Ober C. The sex-specific genetic architecture of quantitative traits in humans. Nat Genet 38: 218-222, 2006.
46. Yagil C, Sapojnikov M, Kreutz R, Katni G, Lindpaintner K, Ganten D, Yagil Y. Salt susceptibility maps to chromosomes 1 and 17 with sex specificity in the Sabra rat model of hypertension. Hypertension 31: 119-124, 1998.
47. Zhang QY, Dene H, Deng AY, Garrett MR, Jacob HJ, Rapp JP. Interval mapping and congenic strains for a blood pressure QTL on rat chromosome 13. Mamm Genome 8: 636-641, 1997.
48. Zhou G, Wen X, Liu H, Schlicht MJ, Hessner MJ, Tonellato PJ, Datta MW. B.E.A.R. GeneInfo: a tool for identifying gene-related biomedical publications through user modifiable queries. BMC Bioinformatics 5: 46, 2004.