A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes

Diabetes

Volumn 56, Issue 6, 2007, Pages 1731-1736

  Wallis, Robert H ^a   Wang, KeSheng ^b   Dabrowski, Dominika ^a   Marandi, Leili ^a   Ning, Terri ^a   Hsieh, Eugene ^a,c   Paterson, Andrew D ^a,b   Mordes, John P ^d   Blankenhorn, Elisabeth P ^e   Poussier, Philippe ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 8; CONGENIC STRAIN; CONTROLLED STUDY; DISEASE RESISTANCE; FEMALE; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOME ANALYSIS; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LINKAGE ANALYSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; TELOMERE;

ANIMALS; CHROMOSOME MAPPING; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; RATS; RATS, INBRED BB; TELOMERE;

EID: 34249739206     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-1790     Document Type: Article

References (27)

1. Mordes JP, Poussier P, Rossini AR, Blankenhorn EP, Greiner DL: Rat Models of Type 1 Diabetes: Genetics, Environment and Autoimmunity. Boca Raton, FL, CRC Press, 2007, p. 1-39
2. Colle E, Fuks A, Poussier P, Edouard P, Guttmann RD: Polygenic nature of spontaneous diabetes in the rat: permissive MHC haplotype and presence of the lymphopenic trait of the BB rat are not sufficient to produce susceptibility. Diabetes 41:1617-1623, 1992
3. Colle E, Guttmann RD, Fuks A: Insulin-dependent diabetes mellitus is associated with genes that map to the right of the class I RT1: a locus of the major histocompatibility complex of the rat. Diabetes 35:454-458, 1986
4. Colle E, Guttmann RD, Seemayer T: Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex. J Exp Med 154:1237-1242, 1981
5. Colle E, Ono SJ, Fuks A, Guttmann RD, Seemayer TA: Association of susceptibility to spontaneous diabetes in rat with genes of major histocompatibility complex. Diabetes 37:1438-1443, 1988
6. Ellerman KE, Like AA: Susceptibility to diabetes is widely distributed in normal class IIu haplotype rats. Diabetologia 43:890-898, 2000
7. Hornum L, Romer J, Markholst H: The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1. Diabetes 51:1972-1979, 2002
8. MacMurray AJ, Moralejo DH, Kwitek AE, Rutledge EA, Van Yserloo B, Gohlke P, Speros SJ, Snyder B, Schaefer J, Bieg S, Jiang J, Ettinger RA, Fuller J, Daniels TL, Pettersson A, Orlebeke K, Birren B, Jacob HJ, Lander ES, Lernmark A: Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res 12:1029-1039, 2002
9. Ramanathan S, Poussier P: BB rat lyp mutation and type 1 diabetes. Immunol Rev 184:161-171, 2001
10. Klaff LS, Koike G, Jiang J, Wang Y, Bieg S, Pettersson A, Lander E, Jacob H, Lernmark A: BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2. Mamm Genome 10:883-887, 1999
11. Kloting II, van den Brandt J, Kovacs P: Quantitative trait loci for blood glucose confirm diabetes predisposing and protective genes, Iddm4 and Iddm5r, in the spontaneously diabetic BB/OK rat. Int J Mol Med 2:597-601, 1998
12. Kloting N, Kloting I: Congenic mapping of type 1 diabetes-protective gene(s) in an interval of 4 Mb on rat chromosome 6q32. Biochem Biophys Res Commun 323:388-394, 2004
13. Jacob HJ, Pettersson A, Wilson D, Mao Y, Lernmark A, Lander ES: Genetic dissection of autoimmune type I diabetes in the BB rat. Nat Genet 2:56-60, 1992
14. Fowell D, Mason D: Evidence that the T-cell repertoire of normal rats contains cells with the potential to cause diabetes: characterization of the CD4-+ T-cell subset that inhibits this autoimmune potential. J Exp Med 177:627-636, 1993
15. Guberski DL, Thomas VA, Shek WR, Like AA, Handler ES, Rossini AA, Wallace JE, Welsh RM: Induction of type I diabetes by Kilham's rat virus in diabetes-resistant BB/Wor rats. Science 254:1010-1013, 1991
16. Martin AM, Blankenhorn EP, Maxson MN, Zhao M, Leif J, Mordes JP, Greiner DL: Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat. Diabetes 48:50-58, 1999
17. Martin AM, Maxson MN, Leif J, Mordes JP, Greiner DL, Blankenhorn EP: Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4. Diabetes 48:2138-2144, 1999
18. Blankenhorn EP, Rodemich L, Martin-Fernandez C, Leif J, Greiner DL, Mordes JP: The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection. Diabetes 54:1233-1237, 2005
19. Ramanathan S, Bihoreau MT, Paterson AD, Marandi L, Gauguier D, Poussier P: Thymectomy and radiation-induced type 1 diabetes in nonlymphopenic BB rats. Diabetes 51:2975-2981, 2002
20. Wallis RH, Wallace KJ, Collins SC, McAteer M, Argoud K, Bihoreau MT, Kaisaki PJ, Gauguier D: Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8. Diabetologia 47:1096-1106, 2004
21. Benson G: Tandem repeats finder: a program to analyze DNA sequences. Nucleic Acids Res 27:573-580, 1999
22. Broman KW, Wu H, Sen S, Churchill GA: R/qtl: QTL mapping in experimental crosses. Bioinformatics 19:889-890, 2003
23. Lander ES, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, Newburg L: MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1:174-181, 1987
24. Lincoln S, Daly M, Lander E: Constructing Genetic Maps With MAPMAKER/EXE 3.0.: Whitehead Institute Technical Report. Cambridge, MA, Whitehead Institute, 1992
25. Wang S, Basten CJ, Zeng Z-B: Windows QTL Cartographer 2.5. Raleigh, NC, Department of Statistics, North Carolina State University, 2005
26. Lander ES, Botstein D: Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121:185-199, 1989
27. Churchill GA, Doerge RW: Empirical threshold values for quantitative trait mapping. Genetics 138:963-971, 1994