Identification of a major gene responsible for type 1 diabetes in the Komeda diabetes-prone rat

Experimental Animals

Volumn 54, Issue 2, 2005, Pages 111-115

  Yokoi, Norihide ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Autoimmune disease; Cblb gene; Komeda diabetes prone rat; Major histocompatibility complex; Type 1 diabetes

Indexed keywords

CASITAS B LINEAGE LYMPHOMA B PROTEIN; GENE PRODUCT; IDDM PROTEIN; KDP1 PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; CBL PROTEIN; CBLB PROTEIN, RAT; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; GENE IDENTIFICATION; GENE MAPPING; GENETIC ANALYSIS; GENETIC PREDISPOSITION; GENETIC RISK; HISTOPATHOLOGY; IMMUNOPATHOGENESIS; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR CLONING; MOUSE STRAIN; MUTATIONAL ANALYSIS; NONHUMAN; NONSENSE MUTATION; PANCREAS ISLET BETA CELL; RAT; REVIEW; T LYMPHOCYTE ACTIVATION; TISSUE SPECIFICITY; TRANSGENIC MOUSE; ANIMAL; DISEASE MODEL; GENETICS; HUMAN; IMMUNOLOGY; METHODOLOGY; MUTATION; PANCREAS ISLET; RAT STRAIN; STOP CODON;

ANIMALIA; RODENTIA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; AUTOIMMUNITY; CLONING, MOLECULAR; CODON, NONSENSE; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; HUMANS; ISLETS OF LANGERHANS; MAJOR HISTOCOMPATIBILITY COMPLEX; MUTATION; PROTO-ONCOGENE PROTEINS C-CBL; RATS; RATS, INBRED STRAINS; UBIQUITIN-PROTEIN LIGASES;

EID: 21444434145     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.54.111     Document Type: Review

References (18)

1. Bachmaier, K, Krawczyk, C., Kozieradzki, I., Kong, Y. Y., Sasaki, T., Oliveira-dos-Santos, A., Mariathasan, S., Bouchard, D., Wakeham, A., Itie, A., Le, J., Olhashi, P.S., Sarosi, I., Nishina, H., Lipkowitz, S., and Pennigher, J.M. 2000. Negative regulation of lymphocyte activation and autoimmuniy by he molecular adaptor Cblb. Nature 403: 211-216.
2. Bowen, M.A., Patel, D.D., Li, X., Modrell, B., Malacko, A.R., Wang, W.C., Marquardt, H., Neubauer, M., Pesando, J. M. and Francke, U. 1995. Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. J. Exp. Med. 181:2213-2220.
3. Chiang, Y.J., Kole, H.K., Brown, K., Naramura, M., Fukuhara, S., Hu, R.-J., Jang, I.K., Gutkind, J.S., Shevach E., and Gu, H. 2000. Cblb regulate the CD28 dependence of T-cell activation. Nature 403: 216-220
4. Davies, J.L., Kawaguchi, Y., Bennett, S.T., Copeman, J.B., Cordell, H.J., Pritchard, L.E., Reed, P.W., Gough, S.C., Jenkins, S.., Palmer, S.M., Balfour, K.M., Rowe, B.R., Farrall, M., Barnett, A.H., Bain, S.C., and Todd, J.A. 1994. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371: 130-136.
5. u haplotype rats. Diabetologia 43: 890-898.
6. Fang, D., Wang, H.Y., Fang, N., Altman, Y., Elly, C., and Liu, Y.C. 2001. Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cell. J. Biol. Chem. 276: 4872-4878.
7. Hornum, L., Romer, J., and Markholst, H. 2002. The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1. Diabetes 51: 1972-1979.
8. Kawano, K., Hirashima, T., Mori, S., Saitoh, Y., Kurosumi, M., and Natori, T. 1991. New inbred strain of Long-Evans Tokushima Lean rats with IDDM without lymphopenia. Diabetes 40: 1375-1381.
9. Keane, M.M., Rivero-Lezcano, O.M., Mitchell, J.A., Robbins, K.C., and Lipkowitz, S. 1995. Cloning and characterization of Cblb: a SH3 binding protein with homology to the c-cbl proto-oncogene. Oncogene 10: 2367-2377.
10. Komeda, K., Noda, M., Terao, K., Kuzuya, N., Kanazawa, M., and Kanazawa, Y. 1998. Establishment of two substrains, diabetes-prone and non-diabetic, from Long-Evans Tokushima Lean (LETL) rats. Endocr. J. 45: 737-744.
11. Kosoy, R., Yokoi, N., Seino, S., and Concannon, P. 2004. Polymorphic variation in the CBLB gene in human type 1 diabetes. Genes Immun. 5: 232-235.
12. MacMurray, A.J., Moralejo, D.H., Kwitek, A.E., Rutledge, E.A., Van Yserloo, B., Gohlke, P., Speros, S.J., Synder, B., Schaefer, J., Bieg, S., Jiang, J., Ettinger, R.A., Fuller, J., Daniels, T.L., Petterson, A., Orlebeke., K., Birren, B., Jacob, H.J., Lander, E.S., and Lernmark, A. 2002. Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res. 12: 1029-1039.
13. Payne, F., Smyth, D.J., Pask, R., Barrat, B.J., Cooper, J.D., Twells, R.C., Walker, N.M., Lam, A.C., Smink, L.J., Nutland, S., Rance, H.E., and Todd, J.A. 2004. Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddml) and Cblb. Diabetes 53: 505-509.
14. Wicker, L.S., Todd, J.A., and Peterson, L.B. 1995. Genetic control of autoimmune diabetes in the NOD mouse. Annu. Rev. Immunol. 13: 179-200.
15. Yokoi, N., Kanazawa, M., Kitada, K., Tanaka, A., Kanazawa, Y., Suda, S., Ito., H., Serikawa, T., and Komeda, K. 1997. A non-MHC locus essential for autoimmune type I diabetes in the Komeda diabetes-prone rat. J. Clin. Invest. 100:2015-2021.
16. Yokoi, N., Komeda, K., Wang, H.-Y., Yano, H., Kitada, K., Saitoh, Y., Seino, Y., Yasuda, K., Serikawa, T., and Seino, S. 2002. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nature Genet. 31: 391-394.
17. Yokoi, N., Namae, M., Fuse, M., Wang, H.-Y., Hirata, T., Seino, S., and Komeda, K. 2003. Establishment and characterization of the Komeda diabetes-prone rat as a segregating inbred strain. Exp. Anim. 52: 295-301.
18. Zhang, J., Bardos, T., Li, D., Gal, I., Vermes, C., Xu, J., Mikecz, K., Finnegan A., Lipkowitz, S., and Glant, T.T. 2002. Cutting edge: regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination. J. Immunol. 169: 2236-2240.