Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation

Genes to Cells

Volumn 14, Issue 7, 2009, Pages 775-788

  Sang, Meixiang ^a,b   Ando, Kiyohiro ^a   Okoshi, Rintaro ^a   Koida, Nami ^a   Li, Yuanyuan ^a   Zhu, Yuyan ^a   Shimozato, Osamu ^a   Geng, Cuizhi ^b   Shan, Baoen ^b   Nakagawara, Akira ^a   Ozaki, Toshinori ^a  

^a CHIBA CANCER CENTER   (Japan)

^b HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; POLO LIKE KINASE 3; PROTEIN P73; SMALL INTERFERING RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FATE; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME MECHANISM; FEMALE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; MICROSCOPY, CONFOCAL; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 67649506339     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2009.01309.x     Document Type: Article

References (33)

1. Alberts, G.F. & Winkles, J.A. (2004) Murine FGF-inducible kinase is rapidly degraded via the nuclear ubiquitin-proteosome system when overexpressed in NIH 3T3 cells. Cell Cycle 3, 678-684.
2. Ando, K., Ozaki, T., Yamamoto, H., Furuya, K., Hosoda, M., Hayashi, S., Fukuzawa, M. & Nakagawara, A. (2004) Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation. J. Biol. Chem. 279, 25549-25561.
3. Conn, C.W., Hennigan, R.F., Dai, W., Sanchez, Y. & Stambrook, P.J. (2000) Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3. Cancer Res. 60, 6826-6831.
4. Donohue, P.J., Alberts, G.F., Guo, Y. & Winkles, J.A. (1995) Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase. J. Biol. Chem. 270, 10351-10357.
5. el Bahassi, M., Conn, C.W., Myer, D.L., Hennigan, R.F., McGowan, C.H., Sanchez, Y. & Stambrook, P.J. (2002) Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways. Oncogene 21, 6633-6640.
6. Elia, A.E., Cantley, L.C. & Yaffe, M.B. (2003) Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science 299, 1228-1231.
7. Feng, Y., Longo, D.L. & Ferris, D.K. (2001) Polo-like kinase interacts with proteasomes and regulates their activity. Cell Growth Differ. 12, 29-37.
8. Gaiddon, C., Lokshin, M., Gross, I., Levasseur, D., Taya, Y., Loeffler, J.-P. & Prives, C. (2003) Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73. J. Biol. Chem. 278, 27421-27431.
9. Gao, M. & Karin, M. (2005) Regulating the regulators: Control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli. Mol. Cell 19, 581-593.
10. Gong, J., Costanzo, A., Yang, H.-Q., Melino, G., Kaelin, W.G. Jr, Levreno, M. & Wang, J.Y. (1999) The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399, 806-809.
11. Gonzalez, S., Prives, C. & Cordon-Cordo, C. (2003) p73α regulation by Chk1 in response to DNA damage. Mol. Cell. Biol. 23, 8161-8171.
12. Jiang, N., Wang, X., Jhanwar-Uniyal, M., Darzynkiewicz, Z. & Dai, W. (2006) Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis. J. Biol. Chem. 281, 10577-10582.
13. Koida, N., Ozaki, T., Yamamoto, H., Ono, S., Koda, T., Ando, K., Okoshi, R., Kamijo, T., Omura, K. & Nakagawara, A. (2008) Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation. J. Biol. Chem. 283, 8555-8563.
14. Li, B., Ouyang, B, Pan, H., Reissmann, P.T., Slamon, D.J., Arceci, R., Lu, L. & Dai, W. (1996) Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas. J. Biol. Chem. 271, 19402-19408.
15. Li, Z., Niu, J., Uwagawa, T., Peng, B. & Chiao, P.J. (2005) Function of polo-like kinase 3 in NF-κB-mediated proapoptotic response. J. Biol. Chem. 280, 16843-16850.
16. Iida, M., Matsuda, M. & Komatani, H. (2008) Plk3 phosphorylates topoisomerase IIa at Thr(1342), a site that is not recognized by Plk1. Biochem. J. 411, 27-32.
17. Liu, Y., Jiang, N., Wu, J., Dai, W. & Rosenblum, J.S. (2007) Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects. J. Biol. Chem. 282, 2505-2511.
18. Lowery, D.M., Lim, D. & Yaffe, M.B. (2005) Structure and function of Polo-like kinases. Oncogene 24, 248-259.
19. Niizuma, H., Nakamura, Y., Ozaki, T., Nakanishi, H., Ohira, M., Isogai, E., Kageyama, H., Imaizumi, M. & Nakagawara, A. (2006) Bcl-2 is a key regulator for the retinoic acid-induced apoptotic cell death in neuroblastoma. Oncogene 25, 5046-5055.
20. Ozaki, T. & Nakagawara, A. (2005) p73, a sophisticated p53 family member in the cancer world. Cancer Sci. 96, 729-737.
21. Ren, J., Datta, R., Shioya, H., Li, Y., Oki, E., Biedermann, V., Bharti, A. & Kufe, D. (2002) p73b is regulated by protein kinase Cd catalytic fragment generated in the apoptotic response to DNA damage. J. Biol. Chem. 277, 33758-33765.
22. Rossi, M., De Laurenzi, V., Munarriz, E., Green, D.R., Liu, Y.C., Vousden, K., Cesareni, G. & Melino, G. (2005) The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J. 24, 836-848.
23. Scheffner, M., Huibregtse, J.M., Vierstra, R.D. & Howley, P.M. (1993) The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75, 495-505.
24. Smith, M.R., Wilson, M.L., Hamanaka, R., Chase, D., Kung, H., Longo, D.L. & Ferris, D.K. (1997) Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase. Biochem. Biophys. Res. Commun. 234, 397-405.
25. Takai, N., Hamanaka, R., Yoshimatsu, J. & Miyakawa, I. (2005) Polo-like kinases (Plks) and cancer. Oncogene, 24, 287-291.
26. Toh, W.H., Siddique, M.M., Boominathan, L., Lin, K.W. & Sabapathy, K. (2004) c-Jun regulates the stability and activity of the p53 homologue, p73. J. Biol. Chem. 279, 44713-44722.
27. Wang, L., Dai, W. & Lu, L. (2007) Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells. J. Biol. Chem. 282, 32121-32127.
28. Wang, Q., Suqing, X., Chen, J., Fukasawa, K., Naik, U., Traganos, F., Darzynkiewicz, Z., Jhanwar-Uniyal, M. & Dai, W. (2002) Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity. Mol. Cell. Biol. 22, 3450-3459.
29. Weichert, W., Denkert, C., Schmidt, M., Gekeler, V., Wolf, G., Kobel, M., Dietel, M. & Hauptmann, S. (2004) Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma. Br. J. Cancer 90, 815-821.
30. Wiest, J., Clark, A.M. & Dai, W. (2001) Intron/exon organization and polymorphisms of the PLK3/PRK gene in human lung carcinoma cell lines. Genes Chromosomes Cancer 32, 384-389.
31. Xie, S., Wu, H., Wang, Q., Cogswell, J.P., Husain, I., Conn, C., Stambrook, P., Jhanwar-Uniyal, M. & Dai, W. (2001) Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway. J. Biol. Chem. 276, 43305-43312.
32. Yang, Y., Bai, J., Shen, R., Brown, S., Komissarova, E., Huang, Y., Jiang, N., Alberts, G.F., Costa, M., Lu, L., Winkles, J.A. & Dai, W. (2008) Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions. Cancer Res. 68, 4077-4085.
33. Zimmerman, W.C. & Erikson, R.L. (2007) Polo-like kinase 3 is required for entry into S phase. Proc. Natl. Acad. Sci. USA 104, 1847-1852.