The immediate early genes, c-fos, c-jun and AP-1, are early markers of platinum analogue toxicity in human proximal tubular cell primary cultures

Toxicology in Vitro

Volumn 23, Issue 5, 2009, Pages 780-788

  Wainford, Richard David ^a   Weaver, Richard J ^b   Hawksworth, Gabrielle M ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b Servier Research and Development Ltd   (United Kingdom)

Author keywords

AP 1; c fos; c jun; Early markers of toxicity; Platinum analogues; Rat and human proximal tubular cell cultures

Indexed keywords

CARBOPLATIN; CISPLATIN; MESSENGER RNA; PROTEIN C FOS; PROTEIN C JUN; TRANSCRIPTION FACTOR AP 1; TRANSPLATIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; HUMAN; HUMAN CELL; IMMEDIATE EARLY GENE; IN VITRO STUDY; KIDNEY CELL CULTURE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MALE; NEPHROTOXICITY; NONHUMAN; PHARMACOGENETICS; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; SPECIES DIFFERENCE;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL MARKERS; CARBOPLATIN; CELLS, CULTURED; CISPLATIN; HUMANS; KIDNEY TUBULES, PROXIMAL; MALE; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SPECIES SPECIFICITY; TIME FACTORS; TRANSCRIPTION FACTOR AP-1;

RATTUS;

EID: 67649472414     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.04.004     Document Type: Article

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