Caveolin-1 deficiency stimulates neointima formation during vascular injury

Biochemistry

Volumn 43, Issue 26, 2004, Pages 8312-8321

  Hassan, Ghada S ^a   Jasmin, Jean François ^a   Schubert, William ^a   Frank, Philippe G ^a   Lisanti, Michael P ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; BLOOD; CELLS; GENETIC ENGINEERING; HISTOLOGY; MUSCLE;

EXTRACELLULAR MATRIX DEPOSITION; GENETIC ABLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CELL (SMC);

PATHOLOGY;

CAVEOLIN 1;

ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL INJURY; CAROTID ARTERY; CELL PROLIFERATION; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; INTIMA; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; CAROTID ARTERIES; CAVEOLIN 1; CAVEOLINS; CELL DIVISION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EXTRACELLULAR MATRIX; GENOTYPE; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY; MICROSCOPY, ELECTRON; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCYTES, SMOOTH MUSCLE; SIGNAL TRANSDUCTION; TIME FACTORS;

ANIMALIA;

EID: 3142579790     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049609t     Document Type: Article

References (34)

1. Ross R. (1993) The pathogenesis of atherosclerosis: A perspective for the 1990s, Nature 362, 801-809.
2. Bassiouny, H. S., White, S., Glagov, S., Choi, E., Giddens, D. P., and Zarins, C. K. (1992) Anastomotic intimal hyperplasia: Mechanical injury or flow induced, J. Vasc. Surg. 15, 708-717.
3. Geary, R. L., Kohler, T. R., Vergel, S., Kirkman, T. R., and Clowes, A. W. (1994) Time course of flow-induced smooth muscle cell proliferation and intimal thickening in endothelialized baboon vascular grafts, Circ. Res. 74, 14-23.
4. Kohler, T. R., Kirkman, T. R., Kraiss, L. W., Zierler, B. K., and Clowes, A. W. (1991) Increased blood flow inhibits neointimal hyperplasia in endothelialized vascular grafts, Circ. Res. 69, 1557-1565.
5. Kumar, A., and Lindner, V. (1997) Remodeling with neointima formation in the mouse carotid artery after cessation of blood flow, Arterioscler., Thromb., Vasc. Biol. 17, 2238-2244.
6. Razani, B., Woodman, S. E., and Lisanti, M. P. (2002) Caveolae: From cell biology to animal physiology, Pharmacol. Rev. 54, 431-467.
7. Razani, B., and Lisanti, M. P. (2001) Caveolin-deficient mice: Insights into caveolar function and human disease, J. Clin. Invest. 108, 1553-1561.
8. Smart, E. J., Graf, G. A., McNiven, M. A., Sessa, W. C., Engelman, J. A., Scherer, P. E., Okamoto, T., and Lisanfi, M. P. (1999) Caveolins, liquid-ordered domains, and signal transduction, Mol. Cell. Biol. 19, 7289-7304.
9. Scherer, P. E., Lewis, R. Y., Volonte, D., Engelman, J. A., Galbiati, F., Couet, J., Kohtz, D. S., van Donselaar, E., Peters, P., and Lisanti, M. P. (1997) Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo, J. Biol. Chem. 272, 29337-29346.
10. Okamoto, T., Schlegel, A., Scherer, P. E., and Lisanti, M. P. (1998) Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane, J. Biol. Chem. 273, 5419-5422.
11. Razani, B., Engelman, J. A., Wang, X. B., Schubert, W., Zhang, X. L., Marks, C. B., Macaluso, F., Russell, R. G., Li, M., Pestell, R. G., Di Vizio, D., Hou, H., Jr, Kneitz, B., Lagaud, G., Christ, G. J., Edelmann, W., and Lisanti, M. P. (2001) Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities, J. Biol. Chem. 276, 38121-38138.
12. Schubert, W., Frank, P. G., Razani, B., Park, D. S., Chow, C. W., and Lisanti, M. P. (2001) Caveolae-deficient endothelial cells show defects in the uptake and transport of albumin in vivo, J. Biol. Chem. 276, 48619-48622.
13. Drab, M., Verkade, P., Elger, M., Kasper, M., Lohn, M., Lauterbach, B., Menne, J., Lindschau, C., Mende, F., Luft, F. C., Schedl, A., Haller, H., and Kurzchalia, T. V. (2001) Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice, Science 293, 2449-2452.
14. Galbiati, F., Volonte, D., Liu, J., Capozza, F., Frank, P. G., Zhu, L., Pestell, R. G., and Lisanti, M. P. (2001) Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism, Mol. Biol. Cell 12, 2229-2244.
15. Lee, H., Park, D. S., Razani, B., Russell, R. G., Pestell, R. G., and Lisanti, M. P. (2002) Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: Caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia, Am. J. Pathol. 161, 1357-1369.
16. Cohen, A. W., Park, D. S., Woodman, S. E., Williams, T. M., Chandra, M., Shirani, J., Pereira de Souza, A., Kitsis, R. N., Russell, R. G., Weiss, L. M., Tang, B., Jelicks, L. A., Factor, S. M., Shtutin, V., Tanowitz, H. B., and Lisanti, M. P. (2003) Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts, Am. J. Physiol. 284, C457-C474.
17. Harmon, K. J., Couper, L. L., and Lindner, V. (2000) Strain-dependent vascular remodeling phenotypes in inbred mice, Am. J. Pathol. 156, 1741-1748.
18. Kraemer, R. (2002) Reduced apoptosis and increased lesion development in the flow-restricted carotid artery of p75(NTR)-null mutant mice, Circ. Res. 91, 494-500.
19. Razani, B., Altschuler, Y., Zhu, L., Pestell, R. G., Mostov, K. E., and Lisanti, M. P. (2000) Caveolin-1 expression is down-regulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation, Biochemistry 39, 13916-13924.
20. Williams, T. M., Cheung, M. W., Park, D. S., Razani, B., Cohen, A. W., Muller, W. J., Di Vizio, D., Chopra, N. G., Pestell, R. G., and Lisanti, M. P. (2003) Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice, Mol. Biol. Cell 14, 1027-1042.
21. Capozza, F., Williams, T. M., Schubert, W., McClain, S., Bouzahzah, B., Sotgia, F., and Lisanti, M. P. (2003) Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation, Am. J. Pathol. 162, 2029-2039.
22. Woodman, S. E., Cheung, M. W., Tarr, M., North, A. C., Schubert, W., Lagaud, G., Marks, C. B., Russell, R. G., Hassan, G. S., Factor, S. M., Christ, G. J., and Lisanti, M. P. (2004) Urogenital alterations in aged male caveolin-1 knockout mice, J. Urol. 171, 950-957.
23. Engelman, J. A., Chu, C., Lin, A., Jo, H., Ikezu, T., Okamoto, T., Kohtz, D. S., and Lisanti, M. P. (1998) Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain, FEBS Lett. 428, 205-211.
24. Couet, J., Sargiacomo, M., and Lisanti, M. P. (1997) Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities, J. Biol. Chem. 272, 30429-30438.
25. Galbiati, F., Volonté, D., Engelman, J. A., Watanabe, G., Burk, R., Pestell, R. G., and Lisanti, M. P. (1998) Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade, EMBO J. 17, 6633-6648.
26. Scheel, J., Srinivasan, J., Honnert, U., Henske, A., and Kurzchalia, T. V. (1999) Involvement of caveolin-1 in meiotic cell-cycle progression in Caenorhabditis elegans, Nat. Cell Biol. 1, 127-129.
27. Hulit, J., Bash, T., Fu, M., Galbiati, F., Albanese, C., Sage, D. R., Schlegel, A., Zhurinsky, J., Shtutman, M., Ben-Ze'ev, A., Lisanti, M. P., and Pestell, R. G. (2000) The cyclin D1 gene is transcriptionally repressed by caveolin-1, J. Biol. Chem. 275, 21203-21209.
28. Sherr, C. J., and Roberts, J. M. (1999) Inhibitors of mammalian G1 cyclin-dependent kinases, Genes Dev. 13, 1501-1512.
29. Kitagawa, M., Higashi, H., Jung, H. K., Sujuki-Takahashi, I., Ikeda, M., Tamai, K., Kato, J., Segawa, K., Yoshida, E., Nishimura, S., and Taya, Y. (1996) The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2, EMBO J. 15, 7060-7069.
30. Cozar-Castellano, I., Takane, K. K., Bottino, R., Balamurugan, A. N., and Stewart, A. F. (2004) Induction of β-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1, Diabetes 53, 149-159.
31. O'Sullivan, M., Scott, S. D., McCarthy, N., Figg, N., Shapiro, L. M., Kirkpatrick, P., and Bennett, M. R. (2003) Differential cyclin E expression in human in-stent stenosis smooth muscle cells identifies targets for selective anti-restenosis therapy, Cardiovasc. Res. 60, 673-683.
32. Roy, J., Tran, P. K., Religa, P., Kazi, M., Henderson, B., Lundmark, K., and Hedin, U. (2002) Fibronectin promotes cell cycle entry in smooth muscle cells in primary culture, Exp. Cell Res. 273, 169-177.
33. Cho, K. A., Ryu, S. J., Park, J. S., Jang, I. S., Ahn, J. S., Kim, K. T., and Park, S. C. (2003) Senescent phenotype can be reversed by reduction of caveolin status, J. Biol. Chem. 278, 27789-27795.
34. Zhang, W., Razani, B., Altschuler, Y., Bouzahzah, B., Mostov, K. E., Pestell, R. G., and Lisanti, M..P. (2000) Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). Transformation suppressor effects of adenovirus-mediated gene delivery of caveolin-1, J. Biol. Chem. 275, 20717-20725.