Downregulation of tonic GABAergic inhibition in a mouse model of fragile X syndrome

Cerebral Cortex

Volumn 19, Issue 7, 2009, Pages 1515-1520

  Curia, Giulia ^a   Papouin, Thomas ^a,b   Séguéla, Philippe ^a   Avoli, Massimo ^a,c,d  

^a MCGILL UNIVERSITY   (Canada)

^b ECOLE NORMALE SUPÉRIEURE   (France)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d NONE   (Canada)

Author keywords

Fragile X; GABA; Patch clamp; Subiculum; Tonic inhibition

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA5; 4 AMINOBUTYRIC ACID A RECEPTOR DELTA; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DOWN REGULATION; ELECTRIC CURRENT; FRAGILE X SYNDROME; GABAERGIC TRANSMISSION; GENE EXPRESSION REGULATION; GENETIC MODEL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PYRAMIDAL NERVE CELL; SYNAPTIC INHIBITION; WILD TYPE;

ANIMALS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURAL INHIBITION; RECEPTORS, GABA-A; SYNAPTIC TRANSMISSION;

EID: 67649427508     PISSN: 10473211     EISSN: 14602199     Source Type: Journal    
DOI: 10.1093/cercor/bhn159     Document Type: Article

References (43)

1. Antar LN, Afroz R, Dictenberg JB, Carroll RC, Bassell GJ. 2004. Metabotropic glutamate receptor activation regulates fragile X mental retardation protein and Fmr1 mRNA localization differentially in dendrites and at synapses. J Neurosci. 24:2648-2655.
2. Antar LN, Bassell GJ. 2003. Sunrise at the synapse: the FMRP mRNP shaping the synaptic interface. Neuron. 37:555-558.
3. Aschrafi A, Cunningham BA, Edelman GM, Vanderklish PW. 2005. The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain. Proc Natl Acad Sci. 102:2180-2185.
4. Atack JR, Bayley PJ, Seabrook GR, Wafford KA, McKernan RM, Dawson GR. 2006. L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors. Neuropharmacology. 51:1023-1029.
5. Bakker CE, Oostra BA. 2003. Understanding fragile X syndrome: insights from animal models. Cytogenet Genome Res. 100:111-123.
6. Bakker CE, Verheij C, Willemsen R, van der Helm R, Oerlemans F, Vermey M, Bygrave A, Hoogeveen AT, Oostra BA, Reyniers E, et al. 1994. Fmr1 knockout mice: a model to study fragile X mental retardation. Cell. 78:23-33.
7. Bear MF, Huber KM, Warren ST. 2004. The mGluR theory of fragile X mental retardation. Trends Neurosci. 27:370-377.
8. Benini R, Avoli M. 2005. Rat subicular networks gate hippocampal output activity in an in vitro model of limbic seizures. J Physiol. 566:885-900.
9. Caraiscos VB, Elliott EM, You-Ten KE, Cheng VY, Belelli D, Newell JG, Jackson MF, Lambert JJ, Rosahl TW, Wafford KA, et al. 2004. Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors. Proc Natl Acad Sci. 101:3662-3667.
10. Centonze D, Rossi S, Mercaldo V, Napoli I, Ciotti MT, De Chiara V, Musella A, Prosperetti C, Calabresi P, Bernardi G, et al. 2008. Abnormal striatal GABA transmission in the mouse model for the fragile X syndrome. Biol Psychiatry. 63:963-973.
11. Cohen I, Navarro V, Clemenceau S, Baulac M, Miles R. 2002. On the origin of interictal activity in human temporal lobe epilepsy in vitro. Science. 298:1418-1421.
12. D'Antuono M, Merlo D, Avoli M. 2003. Involvement of cholinergic and GABAergic systems in the fragile X knockout mice. Neurosci. 119:9-13.
13. A receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome. J Neurosci. 18:8508-8514.
14. A receptor in fragile X syndrome. Brain Res. 1121:238-245.
15. A receptor: a novel target for treatment of fragile X? Trends Neurosci. 30:425-431.
16. El Idrissi A, Ding XH, Scalia J, Trenkner E, Brown WT, Dobkin C. 2005. Decreased GABAA receptor expression in the seizure-prone fragile X mouse. Neurosci Lett. 377:141-146.
17. A-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J Comp Neurol. 359:154-194.
18. Gabrieli JD, Brewer JB, Desmond JE, Glover GH. 1997. Separate neural bases of two fundamental memory processes in the human medial temporal lobe. Science. 276:264-266.
19. A receptor subunit delta in the fragile X knockout mouse model. Neurobiol Dis. 21:346-357.
20. A receptor subunits are necessary for tonic inhibition in the hippocampus? J Neurosci. 28:1421-1426.
21. A receptor a5 subunit-deficient mice. J Neurophysiol. 95:2796-2807.
22. Huber KM, Gallagher SM, Warren ST, Bear MF. 2002. Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc Natl Acad Sci. 99:7746-7750.
23. Kooy RF. 2003. Of mice and the fragile X syndrome. Trends Genet. 19:148-154.
24. Li J, Pelletier MR, Velazquez J-LP, Carlen P. 2002. Reduced cortical synaptic plasticity and GluR1 expression associated with Fragile X mental retardation protein deficiency. Mol Cell Neurosci. 19:138-151.
25. 11C]flumazenil. Neuroimage. 22:22-28.
26. A receptor populations with novel subunit combinations and drug binding profiles identified in brain by α5- and δ-subunit-specific immunopurification. J Biol Chem. 268:5965-5973.
27. Miyashiro KY, Beckel-Mitchener A, Purk TP, Becker KG, Barret T, Liu L, Carbonetto S, Weiler IJ, Greenough WT, Eberwine J. 2003. RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron. 37:417-431.
28. B receptor subunit mRNAs in the hippocampus after kindling and electrically induced status epilepticus. Neurosci. 134:691-704.
29. Oostra BA, Chiurazzi P. 2001. The fragile X gene and its function. Clin Genet. 60:399-408.
30. A receptor expression in the dentate gyrus of the epileptic mutant mouse Stargazer. J Neurosci. 26:8600-8608.
31. A receptor in a mouse model of temporal lobe epilepsy. J Neurosci. 24:8629-8639.
32. Pfaffl MW. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e45.
33. Radonic A, Thulke S, Mackay IM, Landt O, Siegart W, Nitsche A. 2004. Guideline to reference gene selection for quantitative real-time PCR. Biochem Biophys Res Commun. 313:856-862.
34. Scimemi A, Semyanov A, Sperk G, Kullmann DM, Walker MC. 2005. Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus. J Neurosci. 25:10016-10024.
35. Sharp PE, Green C. 1994. Spatial correlates of firing patterns of single cells in the subiculum of the freely moving rat. J Neurosci. 14:2339-2356.
36. Shen H, Gong QH, Yuan M, Smith SS. 2005. Short-term steroid treatment increases δ GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effects. Neuropharmacology. 49:573-586.
37. A receptor subunits in the rat hippocampus I: immunocytochemical distribution of 13 subunits. Neuroscience. 80:987-1000.
38. A-receptor δ subunit. Epilepsia. 43:3-8.
39. Todd PK, Mack KJ, Malter JS. 2003. The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95. Proc Natl Acad Sci. 100:14374-14378.
40. Windpassinger C, Kroisel PM, Wagner K, Petek E. 2002. The human γ-aminobutyric acid A receptor delta (GABRD) gene: molecular characterisation and tissue-specific expression. Gene. 292:25-31.
41. Wozny C, Knopp A, Lehmann TN, Heinemann U, Behr J. 2005. The subiculum: a potential site of epileptogenesis in human temporal lobe epilepsy. Epilepsia. 46:17-21.
42. A receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy. J Neurosci. 27:7520-7531.
43. Zhao M-G, Toyoda H, Ko SW, Ding H-K, Wu L-J, Zhuo M. 2005. Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome. J Neurosci. 25:7385-7392.