Crotalphine, a novel potent analgesic peptide from the venom of the South American rattlesnake Crotalus durissus terrificus

Peptides

Volumn 29, Issue 8, 2008, Pages 1293-1304

  Konno, Katsuhiro ^a   Picolo, Gisele ^a   Gutierrez, Vanessa P ^a   Brigatte, Patrícia ^a   Zambelli, Vanessa O ^a   Camargo, Antonio C M ^a   Cury, Yara ^a  

^a INSTITUTO BUTANTAN   (Brazil)

Author keywords

Antinociception; Crotalphine; Opioid receptor; Pain; Snake venom

Indexed keywords

ANALGESIC AGENT; CARRAGEENAN; CHAPERONE; CROTALPHINE; CROTOXIN A; CYSTEINE; DELTA OPIATE RECEPTOR; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLORNITHYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; KAPPA OPIATE RECEPTOR; MORPHINE; MU OPIATE RECEPTOR; N,N DIALLYLTYROSYL 2 METHYLALANYL 2 METHYLALANYLPHENYLALANYLLEUCINE; NORBINALTORPHIMINE; POLYPEPTIDE; PROSTAGLANDIN E2; PYROGLUTAMIC ACID; SNAKE VENOM;

AMINO ACID SEQUENCE; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DISULFIDE BOND; DOSE RESPONSE; DRUG DETERMINATION; DRUG ISOLATION; DRUG MEGADOSE; DRUG POTENCY; DRUG SYNTHESIS; HOT PLATE TEST; HYPERALGESIA; LOW DRUG DOSE; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT; SNAKE; SOLID PHASE SYNTHESIS; TAIL FLICK TEST;

AMINO ACID SEQUENCE; ANALGESICS; ANIMALS; CROTALID VENOMS; CROTALUS; CROTOXIN; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MOLECULAR SEQUENCE DATA; PAIN MEASUREMENT; PEPTIDES; RATS; RATS, INBRED BB; SOUTH AMERICA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

CROTALUS DURISSUS TERRIFICUS; MUS; RATTUS;

EID: 47649130531     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2008.04.003     Document Type: Article

References (47)

1. Aird S.D., Kaiser I.I., Lewis R.V., and Kruggel W.G. Rattlesnake presynaptic neurotoxins: primary structure and evolutionary origin of the acidic subunit. Biochemistry 24 (1985) 7054-7058
2. Bon C., Bouchier C., Choumet V., Faure G., Jiang M.S., Lambezat M.P., et al. Crotoxin, half-century of investigations on a phospholipase A2 neurotoxin. Acta Physiol Pharmacol Latinoam 39 (1989) 439-448
3. Brazil V. Do emprego da peçonha na terapêutica. Biol Méd São Paulo 1 (1934) 7-21
4. Brigatte P., Hoffmann F.A., Bernardi M.M., Giorgi R., Fernandes I., Takehara H.A., et al. Tolerance to the antinociceptive effect of Crotalus durissus terrificus snake venom in mice is mediated by pharmacodynamic mechanisms. Toxicon 39 (2001) 1399-1410
5. Castro F.R., Farias A.S., Proenca P.L., De La Hoz C., Langone F., Oliveira E.C., et al. The effect of treatment with crotapotin on the evolution of experimental autoimmune neuritis induced in Lewis rats. Toxicon 49 (2007) 299-305
6. Chen R.Z., and Robinson S.E. The effect of cholinergic manipulations on the analgesic response to cobrotoxin in mice. Life Sci 47 (1990) 1949-1954
7. Cunha F.Q., Lorenzetti B.B., Poole S., and Ferreira S.H. Interleukin-8 as a mediator of sympathetic pain. Br J Pharmacol 104 (1991) 765-767
8. Cunha F.Q., Poole S., Lorenzetti B., and Ferreira S.H. The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br J Pharmacol 107 (1992) 660-664
9. Cunha T.M., Verri Jr. W.A., Silva J.S., Poole S., Cunha F.Q., and Ferreira S.H. A cascade of cytokines mediates mechanical inflammatory hypernociception in mice. Proc Natl Acad Sci USA 102 (2005) 1755-1760
10. Cura J.E., Blanzaco D.P., Brisson C., Cura M.A., Cabrol R., Larrateguy L., et al. Phase I and pharmacokinetics study of crotoxin (cytotoxic PLA(2), NSC-624244) in patients with advanced cancer. Clin Cancer Res 8 (2002) 1033-1041
11. D'Amour F.E., and Smith D.L. A method, for determining loss of pain sensation. J Pharmacol Exp Ther 72 (1941) 74-79
12. Dutta A.S., and Chaudhuri A.K. Neuropharmacological studies on the venom of Vipera russelli. Indian J Exp Biol 29 (1991) 937-942
13. Faure G., Guillaume J.L., Camoin L., Saliou B., and Bon C. Multiplicity of acidic subunit isoforms of crotoxin, the phospholipase A2 neurotoxin from Crotalus durissus terrificus venom, results from posttranslational modifications. Biochemistry 30 (1991) 8074-8083
14. Ferreira S.H., Lorenzetti B.B., and Corrêa F.M.A. Central and peripheral antialgesic action of aspirin-like drugs. Eur J Pharmacol 53 (1978) 39-48
15. Ferreira S.H., Lorenzetti B.B., and Poole S. Bradykinm initiates cytokine-mediated inflammatory hyperalgesia. Br J Pharmacol 110 (1993) 1227-1231
16. Ferreira S.H., Lorenzetti B.B., and Rae G.A. Is methylnalorphinium the prototype of an ideal peripheral analgesic?. Eur J Pharmacol 99 (1984) 23-29
17. 2+ dependent process. Prostaglandins 18 (1979) 179-190
18. Ferreira S.H., and Nakamura M. II. Prostaglandin hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists. Prostaglandins 18 (1979) 191-200
19. Ferreira S.H., and Nakamura M. III. Prostaglandin hyperalgesia: relevance of the peripheral effect for the analgesic action of opioid antagonists. Prostaglandins 18 (1979) 201-208
20. Gad S.W., and Weil C.S. Statistics for toxinologists. In: Hayer A. (Ed). Principles and methods of toxicology (1989), Raven Press Ltd., New York 435-483
21. 2 synthesis. Toxicon 42 (2003) 433-437
22. Giorgi R., Bernardi M.M., and Cury Y. Analgesic effect evoked by low molecular weight substances extracted from Crotalus durissus terrificus venom. Toxicon 31 (1993) 1257-1265
23. 1 cannabinoid receptors. Proc Natl Acad Sci 104 (2007) 20588-20593
24. Irwin S., Houde R.W., Bennett D.R., Hendershot L.C., and Seevers M.H. The effects of morphine methadone and meperidine on some reflex responses of spinal animals to nociceptive stimulation. J Pharmacol Exp Ther 101 (1951) 132-143
25. Jacob J.J.C., and Ramabadran K. Enhancement of a nociceptive reaction by opioid antagonists in mice. Br J Pharmacol 64 (1978) 91-98
26. Jensen T.S., and Yaksh T.L. Comparison of antinociceptive action of morphine in the periaqueductal gray medial and paramedial medulla in rat. Brain Res 363 (1986) 99-113
27. Karaki H., Doi K., Sugano S., Uchiwa H., Sugai R., Murakami U., et al. Antihypertensive effect of tryptic hydrolysate of milk casein in spontaneously hypertensive rats. Comp Biochem Physiol C 96 (1990) 367-371
28. Karaki H., Kuwahara M., Sugano S., Doi C., Doi K., Matsumura N., et al. Oral administration of peptides derived from bonito bowels decreases blood pressure in spontaneously hypertensive rats by inhibiting angiotensin converting enzyme. Comp Biochem Physiol C 104 (1993) 351-353
29. Landucci E.C., Antunes E., Donato J.L., Faro R., Hyslop S., Marangoni S., et al. Inhibition of carrageenin-induced rat paw oedema by crotapotin, a polypeptide complexed with phospholipase A2. Br J Pharmacol 114 (1995) 578-583
30. Landucci E.C., De Castro R.C., Toyama M., Giglio J.R., Marangoni S., De Nucci G., et al. Inflammatory oedema induced by the lys-49 phospholipase A(2) homologue piratoxin-i in the rat and rabbit. Effect of polyanions and p-bromophenacyl bromide. Biochem Pharmacol 59 (2000) 1289-1294
31. Laure C.J. The primary structure of crotamine. Hoppe Seylers Z Physiol Chem 356 (1975) 213-215
32. Lorenzetti B.B., and Ferreira S.H. Mode of analgesic action of dypirone: direct antagonism of inflammatory hyperalgesia. Eur J Pharmacol 114 (1985) 375-381
33. Mancin A.C., Soares A.M., Andriao-Escarso S.H., Faca V.M., Greene L.J., Zuccolotto S., et al. The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. Toxicon 36 (1998) 1927-1937
34. Monaelesser A., and Taguet C. Traitement des algies et des tumeurs par le "venin de cobra". Bull Acad Med 109 (1933) 371-376
35. Picolo G., Cassola A.C., and Cury Y. Activation of peripheral ATP-sensitive K+ channels mediates the antinociceptive effect of Crotalus durissus terrificus snake venom. Eur J Pharmacol 469 (2003) 57-64
36. Picolo G., and Cury Y. Peripheral neuronal nitric oxide synthase activity mediates the antinociceptive effect of Crotalus durissus terrificus snake venom, a delta- and kappa-opioid receptor agonist. Life Sci 75 (2004) 559-573
37. Picolo G., Giorgi R., Bernardi M.M., and Cury Y. The antinociceptive effect of Crotalus durissus terrificus snake venom is mainly due to a supraspinally integrated response. Toxicon 36 (1998) 223-227
38. Picolo G., Giorgi R., and Cury Y. Delta-opioid receptors and nitric oxide mediate the analgesic effect of Crotalus durissus terrificus snale venom. Eur J Pharmacol 391 (2000) 55-62
39. Pu X.C., Wong P.T., and Gopalakrishnakone P. A novel analgesic toxin (hannalgesin) from the venom of king cobra (Ophiophagus hannah). Toxicon 33 (1995) 1425-1431
40. Randall L.O., and Selitto J.J. A method for measurement of analgesia activity on inflamed tissue. Arch Inst Pharmacodyn 111 (1957) 209-219
41. Schmauss C., and Yaksh T.L. In vivo studies on spinal opiate receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta and kappa receptors with visceral, chemical and cutaneous thermal stimuli in the rat. J Pharmacol Exp Ther 228 (1984) 1-12
42. Seppo L., Jauhiainen T., Poussa T., and Korpela R. A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. Am J Clin Nutr 77 (2003) 326-330
43. Sipola M., Finckenberg P., Santisteban J., Korpela R., Vapaatalo H., and Nurminen M.L. Long-term intake of milk peptides attenuates development of hypertension in spontaneously hypertensive rats. J Physiol Pharmacol 52 (2001) 745-754
44. Slotta K.H., and Fraenkel-Conrat H. Estudos químicos sobre venenos ofídicos. 4. purificação e cristalização do veneno da cobra cascavel. Mem Inst Butantan 12 (1938) 505-512
45. Suh H.H., Fujimoto J.M., and Tseng L.F. Different radiant heat intensities differentiate intracerebroventricular morphine from β-endorphin-induced inhibition of the tail-flick response in the mouse. Eur J Pharmacol 213 (1992) 337-341
46. Zhang H.L., Han R., Chen Z.X., Chen B.W., Gu Z.L., Reid P.F., et al. Opiate and acetylcholine-independent analgesic actions of crotoxin isolated from crotalus durissus terrificus venom. Toxicon 48 (2006) 175-182
47. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16 (1983) 109-110