NESCA: A new NEMO/IKKgamma and TRAF6 interacting protein

Journal of Cellular Physiology

Volumn 220, Issue 2, 2009, Pages 410-417

  Napolitano, Gennaro ^a   Mirra, Serena ^a   Monfregola, Jlenia ^a   Lavorgna, Alfonso ^b   Leonardi, Antonio ^b   Ursini, Matilde Valeria ^a  

^a INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE GAMMA; NERVE GROWTH FACTOR; NEW MOLECULE CONTAINING SH3 AT CARBOXY TERMINUS; PROTEIN SH3; PROTEIN TYROSINE KINASE A; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; I KAPPA B KINASE; IKBKG PROTEIN, HUMAN; POLYUBIQUITIN; RUSC1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN INTERACTION; UBIQUITINATION; CELL LINE; GENETICS; METABOLISM; PROTEIN BINDING; TWO HYBRID SYSTEM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL LINE; HUMANS; I-KAPPA B KINASE; POLYUBIQUITIN; PROTEIN BINDING; TNF RECEPTOR-ASSOCIATED FACTOR 6; TWO-HYBRID SYSTEM TECHNIQUES; UBIQUITINATION;

EID: 67649382173     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21782     Document Type: Article

References (52)

1. Azoitei N, Wirth T, Baumann B. 2005. Activation of the IkappaB kinase complex is sufficient for neuronal differentiation of PC12 cells. J Neurochem 93:1487-1501.
2. Behl C, Davis JB, Lesley R, Schubert D. 1994. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77:817-827.
3. Brandt JA, Churchill L, Rehman A, Ellis G, Memet S, Israel A, Krueger JM. 2004. Sleep deprivation increases the activation of nuclear factor kappa B in lateral hypothalamic cells. Brain Res 1004:91-97.
4. Carter BD, Kaltschmidt C, Kaltschmidt B, Offenhauser N, Bohm-Matthaei R, Baeuerle PA, Barde YA. 1996. Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75. Science 272:542-545.
5. Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U. 2002. Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. J Biol Chem 277:37029-37036.
6. Chen ZJ. 2005. Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol 7:758-765.
7. Chen Z, Gardi J, Kushikata T, Fang J, Krueger JM. 1999. Nuclear factor-kappaB-like activity increases in murine cerebral cortex after sleep deprivation. Am J Physiol 276:R1812-R1818.
8. Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD. 2008. Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptormediated NF-kappaB activation. Mol Cell Biol 28:3538-3547.
9. Ea CK, Deng L, Xia ZP, Pineda G, Chen ZJ. 2006. Activation of IKKby TNFalpha requires sitespecific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell 22:245-257.
10. Foehr ED, Bohuslav J, Chen LF, DeNoronha C, Geleziunas R, Lin X, O'Mahony A, Greene WC. 2000a. The NF-kappa B-inducing kinase induces PC12 cell differentiation and prevents apoptosis. J Biol Chem 275:34021-34024.
11. Foehr ED, Lin X, O'Mahony A, Geleziunas R, Bradshaw RA, Greene WC. 2000b. NF-kappa B signaling promotes both cell survival and neurite process formation in nerve growth factorstimulated PC12 cells. J Neurosci 20:7556-7563.
12. Friedman WJ, Greene LA. 1999. Neurotrophin signaling via Trks and p75. Exp Cell Res 253:131-142.
13. Fusco F, Bardaro T, Fimiani G, Mercadante V, Miano MG, Falco G, Israel A, Courtois G, D'Urso M, Ursini MV. 2004. Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF-kappaB activation. Hum Mol Genet 13:1763-1773.
14. Fusco F, Pescatore A, Bal E, Ghoul A, Paciolla M, Lioi MB, D'Urso M, Rabia SH, Bodemer C, Bonnefont JP, Munnich A, Miano MG, Smahi A, Ursini MV. 2008. Alterations of the IKBKG locus and diseases: An update and a report of 13 novel mutations. Hum Mutat 29:595-604.
15. Geetha T, Jiang J, Wooten MW.2005. Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling. Mol Cell 20:301-312.
16. Guerrini L, Blasi F, Denis-Donini S. 1995. Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro. Proc Natl Acad Sci USA 92:9077-9081.
17. Gutierrez H, Hale VA, Dolcet X, Davies A. 2005. NF-kappaB signalling regulates the growth of neural processes in the developing PNS and CNS. Development 132:1713-1726.
18. Hayden MS, Ghosh S. 2008. Shared principles in NF-kappaB signaling. Cell 132:344-362.
19. Joung I, Kim HJ, Kwon YK. 2005. p62 modulates Akt activity via association with PKCzeta in neuronal survival and differentiation. Biochem Biophys Res Commun 334:654-660.
20. Kaltschmidt C, Kaltschmidt B, Baeuerle PA. 1995. Stimulation of ionotropic glutamate receptors activates transcription factorNF-kappa B in primary neurons. Proc Natl Acad Sci USA 92:9618-9622.
21. Khursigara G, Orlinick JR, Chao MV. 1999. Association of the p75 neurotrophin receptor with TRAF6. J Biol Chem 274:2597-2600.
22. Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D, Courtois G. 2003. The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature 424:801-805.
23. Leonardi A, Chariot A, Claudio E, Cunningham K, Siebenlist U. 2000. CIKS, a connection to Ikappa B kinase and stress-activated protein kinase. Proc Natl Acad Sci USA 97:10494-10499.
24. Li H, Kobayashi M, Blonska M, You Y, Lin X. 2006. Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation. J Biol Chem 281:13636-13643.
25. MacDonald JI, Kubu CJ,Meakin SO. 2004. Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth. J Cell Biol 164:851-862.
26. Mattson MP, Meffert MK. 2006. Roles for NF-kappaB in nerve cell survival, plasticity, and disease. Cell Death Differ 13:852-860.
27. Mauro C, Pacifico F, Lavorgna A, Mellone S, Iannetti A, Acquaviva R, Formisano S, Vito P, Leonardi A. 2006. ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB. J Biol Chem 281:18482-18488.
28. Meffert MK, Baltimore D. 2005. Physiological functions for brain NF-kappaB. Trends Neurosci 28:37-43.
29. Memet S. 2006. NF-kappaB functions in the nervous system: From development to disease. Biochem Pharmacol 72:1180-1195.
30. Ni CY, Wu ZH, Florence WC, Parekh VV, Arrate MP, Pierce S, Schweitzer B, Van Kaer L, Joyce S, Miyamoto S, Ballard DW, Oltz EM. 2008. Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo. J Immunol 180:7107-7111.
31. Oeckinghaus A, Wegener E, Welteke V, Ferch U, Arslan SC, Ruland J, Scheidereit C, Krappmann D. 2007. Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation. EMBO J 26:4634-4645.
32. Perkins ND. 2006. Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway. Oncogene 25:6717-6730.
33. Poyet JL, Srinivasula SM, Lin JH, Fernandes-Alnemri T, Yamaoka S, Tsichlis PN, Alnemri ES. 2000. Activation of the Ikappa B kinases by RIP via IKKgamma/NEMO-mediated oligomerization. J Biol Chem 275:37966-37977.
34. Riccio A, Pierchala BA, Ciarallo CL, Ginty DD. 1997. An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons. Science 277:1097-1100.
35. Sanz L, Diaz-Meco MT, Nakano H, Moscat J. 2000. The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J 19:1576-1586.
36. Sebban H, Yamaoka S, Courtois G. 2006. Posttranslational modifications of NEMO and its partners in NF-kappaB signaling. Trends Cell Biol 16:569-577.
37. Sebban-Benin H, Pescatore A, Fusco F, Pascuale V, Gautheron J, Yamaoka S, Moncla A, Ursini MV, Courtois G. 2007. Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a newNEMOmutation causing incontinentia pigmenti. HumMol Genet 16:2805-2815.
38. Smahi A, Courtois G, Vabres P, Yamaoka S, Heuertz S, Munnich A, Israel A, Heiss NS, Klauck SM, Kioschis P, Wiemann S, Poustka A, Esposito T, Bardaro T, Gianfrancesco F, Ciccodicola A, D'Urso M, Woffendin H, Jakins T, Donnai D, Stewart H, Kenwrick SJ, Aradhya S, Yamagata T, Levy M, Lewis RA, Nelson DL. 2000. Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium. Nature 405:466-472.
39. Sun L, Deng L, Ea CK, Xia ZP, Chen ZJ. 2004. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell 14:289-301.
40. Tang ED, Wang CY, Xiong Y, Guan KL. 2003. A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J Biol Chem 278:37297-37305.
41. Wood JN. 1995. Regulation of NF-kappa B activity in rat dorsal root ganglia and PC12 cells by tumour necrosis factor and nerve growth factor. Neurosci Lett 192:41-44.
42. Wooten MW. 1999. Function for NF-kB in neuronal survival: Regulation by atypical protein kinase C. J Neurosci Res 58:607-611.
43. Wooten MW, Seibenhener ML, Mamidipudi V, Diaz-Meco MT, Barker PA, Moscat J. 2001. The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. J Biol Chem 276:7709-7712.
44. Wooten MW, Geetha T, Seibenhener ML, Babu JR, Diaz-Meco MT, Moscat J. 2005. The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination. J Biol Chem 280:35625-35629.
45. Wu CJ, Ashwell JD. 2008. NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation. Proc Natl Acad Sci USA 105:3023-3028.
46. Wu CJ, Conze DB, Li T, Srinivasula SM, Ashwell JD. 2006. Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]. Nat Cell Biol 8:398-406.
47. Yamamoto M, Sato S, Saitoh T, Sakurai H, Uematsu S, Kawai T, Ishii KJ, Takeuchi O, Akira S. 2006. Cutting edge: Pivotal function of Ubc13 in thymocyte TCR signaling. J Immunol 177:7520-7524.
48. Yamaoka S, Courtois G, Bessia C, Whiteside ST, Weil R, Agou F, Kirk HE, Kay RJ, Israel A. 1998. Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell 93:1231-1240.
49. Yeiser EC, Rutkoski NJ, Naito A, Inoue J, Carter BD. 2004. Neurotrophin signaling through the p75 receptor is deficient in traf6-/- mice. J Neurosci 24:10521-10529.
50. Zhang SQ, Kovalenko A, Cantarella G, Wallach D. 2000a. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Immunity 12:301-311.
51. Zhang Y, Moheban DB, Conway BR, Bhattacharyya A, Segal RA. 2000b. Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGFinduced differentiation. J Neurosci 20:5671-5678.
52. Zhou H, Wertz I, O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit VM. 2004. Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. Nature 427:167-171.