Studies towards a novel synthesis of tubulysins: Highly asymmetric aza-Michael reactions of 2-enoylthiazoles with metalated chiral oxazolidinones

Synlett

Volumn , Issue 8, 2009, Pages 1341-1345

  Shankar P , Sreejith ^a   Sani, Monica ^b,c   Terraneo, Giancarlo ^a   Zanda, Matteo ^c,d  

^a POLITECNICO DI MILANO   (Italy)

^b KemoTech srl   (Italy)

^c CNR   (Italy)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Asymmetric; Aza Michael reaction; Diastereoselectivity; Noncatalytic; Oxazolidinone

Indexed keywords

CYTOTOXIC AGENT; OXAZOLIDINONE DERIVATIVE; PEPTIDE DERIVATIVE; THIAZOLE DERIVATIVE; TUBULYSIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC SYNTHESIS; CATALYST; CHIRALITY; CRYSTAL STRUCTURE; DIASTEREOISOMER; METALLATION; MICHAEL ADDITION; QUANTUM YIELD; REACTION ANALYSIS; REACTION TIME; STEREOCHEMISTRY;

EID: 67649382037     PISSN: 09365214     EISSN: 14372096     Source Type: Journal    
DOI: 10.1055/s-0029-1216729     Document Type: Article

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