Highly stereoselective tandem aza-Michael addition-enolate protonation to form partially modified retropeptide mimetics incorporating a trifluoroalanine surrogate

Angewandte Chemie - International Edition

Volumn 42, Issue 18, 2003, Pages 2060-2063

  Sani, Monica ^a   Bruché, Luca ^b   Chiva, Gema ^c   Fustero, Santos ^c   Piera, Julio ^c   Volonterio, Alessandro ^b   Zanda, Matteo ^a  

^a CNR   (Italy)

^b POLITECNICO DI MILANO   (Italy)

^c UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Diastereoselectivity; Michael addition; Peptidomimetics; Protonation; Solvent effects

Indexed keywords

ADDITION REACTIONS; PROTONS; REACTION KINETICS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

PROTONATION;

BIOMIMETIC MATERIALS;

ALANINE DERIVATIVE; PEPTIDE DERIVATIVE; TRIFLUOROALANINE; UNCLASSIFIED DRUG;

ARTICLE; MICHAEL ADDITION; PROTON TRANSPORT; REACTION ANALYSIS; REACTION OPTIMIZATION; SOLVENT EFFECT; STEREOCHEMISTRY; SYNTHESIS;

EID: 0038587652     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200250711     Document Type: Article

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