The use of benzodiazpines and related drugs amongst older people in Sweden: Associated factors and concomitant use of other psychotropics

International Journal of Geriatric Psychiatry

Volumn 24, Issue 7, 2009, Pages 731-738

  Johnell, Kristina ^a   Fastbom, Johan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Benzodiazepines; Elderly; Pharmacoepidemiology; Psychotropic drugs; Register based research

Indexed keywords

ALPRAZOLAM; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; BENZODIAZEPINE DERIVATIVE; CLONAZEPAM; DIAZEPAM; FLUNITRAZEPAM; HYPNOTIC SEDATIVE AGENT; LORAZEPAM; MIDAZOLAM; NEUROLEPTIC AGENT; NITRAZEPAM; OXAZEPAM; PSYCHOTROPIC AGENT; TRIAZOLAM; ZALEPLON; ZOLPIDEM; ZOPICLONE;

AGE; AGED; ARTICLE; CONTROLLED STUDY; DRUG USE; FEMALE; GENDER; GERONTOPSYCHIATRY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRESCRIPTION; PSYCHOPHARMACOTHERAPY; SWEDEN; URBAN AREA;

AGED; AGED, 80 AND OVER; BENZODIAZEPINES; DRUG INTERACTIONS; FEMALE; HEALTH SERVICES FOR THE AGED; HUMANS; MALE; PHARMACOEPIDEMIOLOGY; PSYCHOMOTOR PERFORMANCE; PSYCHOTROPIC DRUGS; SWEDEN;

EID: 67649306968     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.2189     Document Type: Article

References (50)

1. Barbone F, McMahon AD, Davey PG, et al. 1998. Association of road-traffic accidents with benzodiazepine use. Lancet 352: 1331-1336.
2. Bogunovic OJ, Greenfield SF. 2004. Practical geriatrics: use of benzodiazepines among elderly patients. Psychiatr Serv 55: 233-235.
3. Brodeur MR, Stirling AL. 2001. Delirium associated with zolpidem. Ann Pharmacother 35: 1562-1564.
4. Cheng JS, Huang WF, Lin KM, et al. 2008. Characteristics associated with benzodiazepine usage in elderly outpatients in Taiwan. Int J Geriatr Psychiatry 23: 618-624.
5. Cimolai N. 2007. Zopiclone: is it a pharmacologic agent for abuse? Can Fam Physician 53: 2124-2129.
6. Closser MH. 1991. Benzodiazepines and the elderly. A review of potential problems. J Subst Abuse Treat 8: 35-41.
7. Cumming RG, Le Couteur DG. 2003. Benzodiazepines and risk of hip fractures in older people: a review of the evidence. CNS Drugs 17: 825-837.
8. Drover DR. 2004. Comparative pharmacokinetics and pharmacodynamics of short-acting hypnosedatives: zaleplon, zolpidem and zopiclone. Clin Pharmacokinet 43: 227-238.
9. Fick DM, Cooper JW, Wade WE, et al. 2003. Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med 163: 2716-2724.
10. Fourrier A, Letenneur L, Dartigues JF, et al. 2001. Benzodiazepine use in an elderly community-dwelling population. Characteristics of users and factors associated with subsequent use. Eur J Clin Pharmacol 57: 419-425.
11. Glass J, Lanctot KL, Herrmann N, et al. 2005. Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits. BMJ 331: 1169.
12. Gray SL, LaCroix AZ, Hanlon JT, et al. 2006. Benzodiazepine use and physical disability in community-dwelling older adults. J Am Geriatr Soc 54: 224-2230.
13. Gustavsen I, Bramness JG, Skurtveit S, et al. 2008. Road traffic accident risk related to prescriptions of the hypnotics zopiclone, zolpidem, flunitrazepam and nitrazepam. Sleep Med 9: 818-822.
14. Hanlon JT, Horner RD, Schmader KE, et al. 1998. Benzodiazepine use and cognitive function among community-dwelling elderly. Clin Pharmacol Ther 64: 684-692.
15. Hardell L, Carlberg M, Hansson Mild K. 2005. Use of cellular telephones and brain tumour risk in urban and rural areas. Occup Environ Med 62: 390-394.
16. Hartikainen S, Rahkonen T, Kautiainen H, et al. 2003. Kuopio 75+ study: does advanced age predict more common use of psychotropics among the elderly? Int Clin Psychopharmacol 18: 163-167.
17. Hausken AM, Furu K, Skurtveit S, et al. Starting insomnia treatment: the use of benzodiazepines versus z-hypnotics. A prescription database study of predictors. Eur J Clin Pharmacol, in press.
18. Johnell K, Fastbom J, Rosen M, et al. 2007a. Inappropriate drug use in the elderly: a nationwide register-based study. Ann Pharmacother 41: 1243-1248.
19. Johnell K, Fastbom J, Rosen M, et al. 2007b. Low quality of drug use among the elderly. An analysis based on the national drug registry shows regional differences. Läkartidningen 104: 2158-2162.
20. Kirby M, Denihan A, Bruce I, et al. 1999. Benzodiazepine use among the elderly in the community. Int J Geriatr Psychiatry 14: 280-284.
21. Laroche ML, Charmes JP, Merle L. 2007. Potentially inappropriate medications in the elderly: a French consensus panel list. Eur J Clin Pharmacol 63: 725-731.
22. Lau HS, de Boer A, Beuning KS, et al. 1997. Validation of pharmacy records in drug exposure assessment. J Clin Epidemiol 50: 619-625.
23. Linjakumpu T, Hartikainen S, Klaukka T, et al. 2003. A model to classify the sedative load of drugs. Int J Geriatr Psychiatry 18: 542-544.
24. Llorente MD, David D, Golden AG, et al. 2000. Defining patterns of benzodiazepine use in older adults. J Geriatr Psychiatry Neurol 13: 150-160.
25. Lovheim H, Sandman PO, Kallin K, et al. 2008. Symptoms of mental health and psychotropic drug use among old people in geriatric care, changes between 1982 and2000. Int J Geriatr Psychiatry 23: 289-294.
26. Madhusoodanan S, Bogunovic OJ. 2004. Safety of benzodiazepines in the geriatric population. Expert Opin Drug Saf 3: 485-493.
27. Maidment R, Livingston G, Katona C. 2002. Just keep taking the tablets: adherence to antidepressant treatment in older people in primary care. Int J Geriatr Psychiatry 17: 752-757.
28. McLeod PJ, Huang AR, Tamblyn RM, et al. 1997. Defining inappropriate practices in prescribing for elderly people: a national consensus panel. CMAJ 156: 385-391.
29. McMahon AD. 2003. Approaches to combat with confounding by indication in observational studies of intended drug effects. Pharmacoepidemiol Drug Saf 12: 551-558.
30. Opedal K, Schjott J, Eide E. 1998. Use of hypnotics among patients in geriatric institutions. Int J Geriatr Psychiatry 13: 846-851.
31. Puustinen J, Nurminen J, Kukola M, et al. 2007. Associations between use of benzodiazepines or related drugs and health, physical abilities and cognitive function: a non-randomised clinical study in the elderly. Drugs Aging 24: 1045-1059.
32. Ray WA. 1992. Psychotropic drugs and injuries among the elderly: a review. J Clin Psychopharmacol 12: 386-396.
33. Schneeweiss S, Patrick AR, Sturmer T, et al. 2007. Increasing levels of restriction in pharmacoepidemiologic database studies of elderly and comparison with randomized trial results. Med Care 45: S131-142.
34. Schneeweiss S, Seeger JD, Maclure M, et al. 2001. Performance of comorbidity scores to control for confounding in epidemiologic studies using claims data. Am J Epidemiol 154: 854-864.
35. Shorr RI, Robin DW. 1994. Rational use of benzodiazepines in the elderly. Drugs Aging 4: 9-20.
36. Signorello LB, McLaughlin JK, Lipworth L, et al. 2002. Confounding by indication in epidemiologic studies of commonly used analgesics. Am J Ther 9: 199-205.
37. Siriwardena AN, Qureshi Z, Gibson S, et al. 2006. GPs' attitudes to benzodiazepine and 'Z-drug' prescribing: a barrier to implementation of evidence and guidance on hypnotics. Br J Gen Pract 56: 964-967.
38. Statistics Sweden. Area range of H regions (in Swedish). http://www.scb.se/Grupp/Regionalt/rg0104/H_regioner_farg.pdf.
39. Statistics Sweden. The population in Sweden according to sex and age 31/ 12/2005.
40. Taylor S, McCracken CF, Wilson KC, et al. 1998. Extent and appropriateness of benzodiazepine use. Results from an elderly urban community. Br J Psychiatry 173: 433-438.
41. Terzano MG, Rossi M, Palomba V, et al. 2003. New drugs for insomnia: comparative tolerability of zopiclone, zolpidem and zaleplon. Drug Saf 26: 261-282.
42. The Swedish National Board of Health and Welfare. 2000. The quality of drug use among the elderly (in Swedish). Socialstyrelsen följer upp och utvärderar. 2000:8.
43. Walsh JK, Soubrane C, Roth T. 2008. Efficacy and safety of zolpidem extended release in elderly primary insomnia patients. Am J Geriatr Psychiatry 16: 44-57.
44. van Vliet P, van der Mast RC, van den Broek M, et al. Use of benzodiazepines, depressive symptoms and cognitive function in old age. Int J Geriatr Psychiatry, in press.
45. Wang PS, Bohn RL, Glynn RJ, et al. 2001a. Hazardous benzodiazepine regimens in the elderly: effects of half-life, dosage, and duration on risk of hip fracture. Am J Psychiatry 158: 892-898.
46. Wang PS, Bohn RL, Glynn RJ, et al. 2001b. Zolpidem use and hip fractures in older people. J Am Geriatr Soc 49: 1685-1690.
47. Wettermark B, Hammar N, Fored CM, et al. 2007. The new Swedish Prescribed Drug Register - opportunities for pharmacoepidemiological research and experience from the first six months. Pharmacoepidemiol Drug Saf 16: 726-735.
48. WHO. Collaborating Centre for Drug Statistics Methodology, Oslo, Norway. About the ATC/DDD system. http://www.whocc.no/atcddd/.
49. Windle A, Elliot E, Duszynski K, et al. 2007. Benzodiazepine prescribing in elderly Australian general practice patients. Aust N Z J Public Health 31: 379-381.
50. Zubenko GS, Sunderland T. 2000. Geriatric psychopharmacology: why does age matter? Harv Rev Psychiatry 7: 311-333.