Associations between use of benzodiazepines or related drugs and health, physical abilities and cognitive function: A non-randomised clinical study in the elderly

Drugs and Aging

Volumn 24, Issue 12, 2007, Pages 1045-1059

  Puustinen, Juha ^a,b,c   Nurminen, Janne ^a,b,c   Kukola, Matti ^d   Vahlberg, Tero ^a   Laine, Kari ^a,e   Kivelä, Sirkka Liisa ^a,b,e  

^a UNIVERSITY OF TURKU   (Finland)

^b SATAKUNTA CENTRAL HOSPITAL   (Finland)

^c Harkatie Health Center   (Finland)

^d Central Hospital of Pori   (Finland)

^e TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Alprazolam, therapeutic use; Benzodiazepines, therapeutic use; Chlordiazepoxide, therapeutic use; Cognitive function; Diazepam, therapeutic use; Elderly; Lorazepam, therapeutic use; Nitrazepam, therapeutic use; Oxazepam, therapeutic use

Indexed keywords

ALPRAZOLAM; BENZODIAZEPINE; BENZODIAZEPINE DERIVATIVE; CHLORDIAZEPOXIDE; DIAZEPAM; LORAZEPAM; NITRAZEPAM; OXAZEPAM; TEMAZEPAM; ZOLPIDEM; ZOPICLONE;

AGED; ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMENTIA; DEPRESSION; DIZZINESS; DRUG BLOOD LEVEL; DRUG USE; FATIGUE; FEMALE; GERIATRICS; HEALTH STATUS; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; INTERVIEW; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; MEMORY DISORDER; MINI MENTAL STATE EXAMINATION; MONOTHERAPY; NIGHT SLEEP; PHYSICAL CAPACITY; PHYSICAL DISABILITY; PRIORITY JOURNAL; SLEEP DISORDER; TREATMENT DURATION; WAKEFULNESS; WALKING;

EID: 36348994809     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-200724120-00007     Document Type: Article

References (22)

1. Neutel CI, Perry S, Maxwell C. Medication use and risk of falls. Pharmacoepidemiol Drug Saf 2002; 11 (2): 97-104
2. Barker MJ, Greenwood KM, Jackson M, et al. Cognitive effects of long-term benzodiazepine use: a meta-analysis. CNS Drugs 2004; 18 (1): 37-48
3. Linjakumpu T, Hartikainen S, Klaukka T, et al. Psychotropics among the home-dwelling elderly: increasing trends. Int J Geriatr Psychiatry 2002; 17 (9): 874-83
4. Paakkari P, Voipio T. The growing consumption of hypnotics and sedatives evens out. TABU (drug information from the National Agency for Medicines, Finland) 2005; (3): 37-8
5. Ohayon MM, Caulet M, Priest RG, et al. Psychotropic medication consumption patterns in the UK general population. J Clin Epidemiol 1998; 51 (3): 273-83
6. Ohayon MM, Lader MH. Use of psychotropic medication in the general population of France, Germany, Italy, and the United Kingdom. J Clin Psychiatry 2002; 63 (9): 817-25
7. Vermeeren A. Residual effects of hypnotics: epidemiology and clinical implications. CNS Drugs 2004; 18 (5): 297-328
8. Barker MJ, Greenwood KM, Jackson M, et al. Persistence of cognitive effects after withdrawal from long-term benzodiazepine use: a meta-analysis. Arch Clin Neuropsychol 2004; 19 (3): 437-54
9. Poyares D, Guilleminault C, Ohayon MM, et al. Chronic benzodiazepine usage and withdrawal in insomnia patients. J Psychiatr Res 2004; 38 (3): 327-34
10. Glass J, Lanctot KL, Herrmann N, et al. Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits. BMJ 2005; 331 (7526): 1169-76
11. National Agency for Medicines. Drug consumption statistics [online]. Available from URL: http://www.nam.fi/english/medicines/drug_consumption/index. html [Accessed 2006 Dec 15]
12. National Agency of Medicines. Classification of medicines (ATC) and defined daily doses (DDD) 2004. Helsinki: National Agency of Medicines, 2004
13. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12 (3): 189-98
14. Salokangas RK, Stengard E, Poutanen O. DEPS: a new tool in screening for depression. Duodecim 1994; 110 (12): 1141-8
15. World Health Organization. Tautiluokitus ICD-10 (Classification of Diseases ICD-10). Rauma: Kirjapaino Oy West Point, 1995
16. Laakkonen UM, Heiskanen A. Screening and quantitation of benzodiazepines in serum samples. In: Kaempe B, editor. T.I.A.F.T., proceedings of the 29th international meeting. Copenhagen: Mackeenzie, 1991: 262-6
17. Byles JE, Mishra GD, Harris MA, et al. The problems of sleep for older women: changes in health outcomes. Age Ageing 2003; 32 (2): 154-63
18. Christer GM, Hublin CGM, Partinen MM. The extent and impact of insomnia as a public health problem. Prim Care Companion J Clin Psychiatry 2002; 4 Suppl. 1: 8-12
19. Nielsen GH, Nordhus JH, Kvale G. Clinical geropsychology. In: Nordhus JH, Vandenbos GR, Berg S, et al., editors. Insomnia in older adults. Washington, DC: American Psychiatric Association, 1998: 167-75
20. Morgan K. Sleep problems in the elderly. In: Woods RT, editor. Handbook of the clinical psychology of ageing. Chichester: John Wiley & Sons, 1996: 303-14
21. Neubauer DN. Sleep problems in the elderly. Am Fam Physician 1999; 59 (9): 2551-8, 2559-60
22. Socialstyrelsen/National Board of Social Welfare, Sweden. Indikatorer för utvärdering av kvaliteten i äldres läkemedelsterapia [indicators for evaluating the quality of medication therapy in the aged]. Stockholm: Socialstyrelsen/National Board of Social Welfare, Sweden, 2003: report no. 2003-110-20