Sedative hypnotics in older people with insomnia: Meta-analysis of risks and benefits

British Medical Journal

Volumn 331, Issue 7526, 2005, Pages 1169-1173

  Glass, Jennifer ^a   Lanctôt, Krista L ^a   Herrmann, Nathan ^e,f   Sproule, Beth A ^b,d   Busto, Usoa E ^b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^c Clinical Neuroscience Section   (Canada)

^d Department of Hematology and Oncology   (Japan)

^e UNIVERSITY OF TORONTO   (Canada)

^f Division of Geriatric Psychiatry   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HYPNOTIC AGENT; PLACEBO; ZALEPLON; ZOLPIDEM; ZOPICLONE;

ADULT; AGED; AMNESIA; ARTICLE; ATAXIA; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; CONFIDENCE INTERVAL; CONFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA BASE; DISORIENTATION; DIZZINESS; DOUBLE BLIND PROCEDURE; FALLING; FATIGUE; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MEDLINE; MEMORY DISORDER; META ANALYSIS; PRIORITY JOURNAL; PSYCHOMOTOR DEVELOPMENT; PSYCHOMOTOR DISORDER; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; RISK FACTOR; SEDATION; SIDE EFFECT; SLEEP; STATISTICAL SIGNIFICANCE; SYSTEMATIC REVIEW; WAKEFULNESS;

COGNITION DISORDERS; HUMANS; HYPNOTICS AND SEDATIVES; PSYCHOMOTOR DISORDERS; PUBLICATION BIAS; RANDOMIZED CONTROLLED TRIALS; SLEEP INITIATION AND MAINTENANCE DISORDERS;

EID: 28044462641     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.38623.768588.47     Document Type: Article

References (22)

1. Brostrom A, Stromberg A, Dahlstrom U, Fridlund B. Sleep difficulties, daytime sleepiness, and health-related quality of life in patients with chronic heart failure. J Cardiovasc Nurs 2004;19:234-42.
2. Byles JE, Mishra GD, Harris MA, Nair K. The problems of sleep for older women: changes in health outcomes. Age Ageing 2003;32:154-63.
3. Ohayon MM. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev 2002;6:97-111.
4. Holbrook AM, Crowther R, Lotter A, Cheng C, King D. The diagnosis and management of insomnia in clinical practice: a practical evidence-based approach. CMAJ 2000;162:206-10.
5. Aparasu RR, Mort JR, Brandt H. Psychotropic prescription use by community-dwelling elderly in the United States. J Am Geriatr Soc 2003;51:671-7.
6. Craig D, Passmore AP, Fullerton KJ, Beringer TR, Gilmore DH, Crawford VL, et al. Factors influencing prescription of CNS medications in different elderly populations. Pharmacoepidemiol Drug Saf 2003;12:383-7.
7. Barbone F, McMahon AD, Davey PG, Morris AD, Reid IC, McDevitt DG, et al. Association of road-traffic accidents with benzodiazepine use. Lancet 1998;352:1331-6.
8. Neutel CI, Perry S, Maxwell C. Medication use and risk of falls. Pharmacoepidemiol Drug Saf 2002;11:97-104.
9. Fleming JAE. Insomnia. In: Gray J, ed. Therapeutic choices. Ottawa: Canadian Pharmacists Association, 2003:54-62.
10. Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale, NJ: Earlbaum, 1988.
11. Nowell PD, Mazumdar S, Buysse DJ, Dew MA, Reynolds CF 3rd, Kupfer DJ. Benzodiazepines and zolpidem for chronic insomnia: a meta-analysis of treatment efficacy. JAMA 1997;278:2170-7.
12. Smith MT, Perlis ML, Park A, Smith MS, Pennington J, Giles DE, et al. Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia. Am J Psychiatry 2002;159:5-11.
13. Holbrook A, Crowther R, Lotter A, Cheng C, King D. Meta-analysis of benzodiazepine use in the treatment of insomnia. CMAJ 2000;162:225-33.
14. Wysowski D, Barash D. Adverse behavioural reactions attibuted to triazolam in the Food and Drug Administration's spontaneous reporting system. Arch Intern Med 1991;151:3003-8.
15. American Sleep Disorders Association. International classification of sleep disorders diagnostics and coding manual. Rochester, MN: ASDA, 1990.
16. Mort JR, Aparasu RR. Prescribing of psychotropics in the elderly: why is it so often inappropriate? CNS Drugs 2002;16:99-109.
17. Kallin K, Jensen J, Olsson LL, Nyberg L, Gustafson Y. Why the elderly fall in residential care facilities, and suggested remedies. J Fam Pract 2004;53:41-52.
18. Greenblatt D, Harmatz JS, Shapiro L, Engelhardt N, Gouthro TA, Shader RI. Sensitivity to triazolam in the elderly. N Engl J Med 1991;324:1691-8.
19. Greenblatt D, Shader RI, Harmatz JS. Implications of altered drug disposition in the elderly: studies of benzodiazepines. J Clin Pharmacol 1989;29:866-72.
20. Greenblatt DJ, Harmatz JS, von Moltke LL, Wright CE, Shader RI. Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate. Clin Pharmacol Ther 2004;76:467-79.
21. Morin C, Culbert JP, Schwartz SM. Nonpharmacological interventions for insomnia: a meta-analysis of treatement efficacy. Am J Psychiatry 1994;151:1172-80.
22. Murtagh D, Greenwood KM. Identifying effective psychological treatments for insomnia: a meta-analysis. J Consult Clin Psychol 1995;63:79-89.