Use of benzodiazepines, depressive symptoms and cognitive function in old age

International Journal of Geriatric Psychiatry

Volumn 24, Issue 5, 2009, Pages 500-508

  van Vliet, Peter ^a   van der Mast, Roos C ^a   van den Broek, Marianne ^a   Westendorp, Rudi G J ^a   de Craen, Anton J M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Benzodiazepines; Cognitive function; Depressive symptoms; Elderly

Indexed keywords

BENZODIAZEPINE DERIVATIVE;

AGED; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DEPRESSION; DRUG WITHDRAWAL; EDUCATIONAL STATUS; GERIATRIC DEPRESSION SCALE; GERIATRIC PATIENT; HUMAN; MAJOR CLINICAL STUDY; MINI MENTAL STATE EXAMINATION; PRESCRIPTION; SEX DIFFERENCE;

AGED, 80 AND OVER; AGING; BENZODIAZEPINES; COGNITION; COGNITION DISORDERS; DEPRESSION; EDUCATIONAL STATUS; FEMALE; GERIATRIC ASSESSMENT; HUMANS; INSTITUTIONALIZATION; MALE; NETHERLANDS; NEUROPSYCHOLOGICAL TESTS; PROSPECTIVE STUDIES; TIME FACTORS;

EID: 67649371364     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.2143     Document Type: Article

References (35)

1. Balestrieri M, Marcon G, Samani F, et al. 2005. Mental disorders associated with benzodiazepine use among older primary care attenders a regional survey. Soc Psychiatry Psychiatr Epidemiol 40(4): 308-315.
2. Bergdahl E, Gustavsson JM, Kallin K, et al. 2005. Depression among the oldest old: the Umea 85+ study. Int Psychogeriatr 17(4): 557-575.
3. Birkenhager TK, Moleman P, Nolen WA. 1995. Benzodiazepines for depression? A review of the literature. Int Clin Psychopharmacol 10(3): 181-195.
4. Bogunovic OJ, Greenfield SF. 2004. Practical geriatrics: use of benzodiazepines among elderly patients. Psychiatr Serv 55(3): 233-235.
5. Bootsma van der Wiel A, van Exel E, de Craen AJ, et al. 2002. A high response is not essential to prevent selection bias: results from the Leiden 85-plus study. J Clin Epidemiol 55(11): 1119-1125.
6. Brambilla P, Perez J, Barale F, et al. 2003. GABAergic dysfunction in mood disorders. Mol Psychiatry 8(8): 721-737; 715.
7. Broderick PA, Hope O, Jeannot P. 1998. Mechanism of triazoloben-zodiazepine and benzodiazepine action in anxiety and depression: behavioral studies with concomitant in vivo CA1 hippocampal norepinephrine and serotonin release detection in the behaving animal. Prog Neuropsychopharmacol Biol Psychiatry 22(2): 353-386.
8. Burton DG, Allen MC, Bird JL, Faragher RG. 2005. Bridging the gap: ageing, pharmacokinetics and pharmacodynamics. J Pharm Pharmacol 57(6): 671-679.
9. Dailly E, Chenu F, Renard CE, Bourin M. 2004. Dopamine, depression and antidepressants. Fundam Clin Pharmacol 18(6): 601-607.
10. de Craen AJ, Heeren TJ, Gussekloo J. 2003. Accuracy of the 15-item geriatric depression scale (GDS-15) in a community sample of the oldest old. Int J Geriatr Psychiatry 18(1): 63-66.
11. Delgado PL, Moreno FA. 2000. Role of norepinephrine in depression. J Clin Psychiatry 61(Suppl 1): 5-12.
12. Folstein MF, Folstein SE, McHugh PR. 1975. Mini-Mental State'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3): 189-198.
13. Fourrier A, Letenneur L, Dartigues, et al. 2001. Benzodiazepine use in an elderly community-dwelling population. Characteristics of users and factors associated with subsequent use. Eur J Clin Pharmacol 57(5): 419-425.
14. Foy A, O'Connell D, Henry D, et al. 1995. Benzodiazepine use as a cause of cognitive impairment in elderly hospital inpatients. J Gerontol A Biol Sci Med Sci 50(2): M99-106.
15. Furukawa TA, Streiner DL, Young LT. 2002. Antidepressant and benzodiazepine for major depression. Cochrane Database Syst Rev: CD001026.
16. Hanlon JT, Horner RD, Schmader KE, et al. 1998. Benzodiazepine use and cognitive function among community-dwelling elderly. Clin Pharmacol Ther 64(6): 684-692.
17. Hogan DB, Maxwell CJ, Fung TS, Ebly EM. 2003. Prevalence and potential consequences of benzodiazepine use in senior citizens: results from the Canadian Study of Health and Aging. Can J Clin Pharmacol 10(2): 72-77.
18. Houx PJ, Shepherd J, Blauw GJ, et al. 2002. Testing cognitive function in elderly populations: the PROSPER study. PROspective Study of Pravastatin in the Elderly at Risk. J Neurol Neurosurg Psychiatry 73(4): 385-389.
19. Moller JT, Cluitmans P, Rasmussen LS, et al. 1998. Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. Lancet 351(9106): 857-861.
20. Murai T, Koshikawa N, Kanayama T, et al. 1994. Opposite effects of midazolam and beta-carboline-3-carboxylate ethyl ester on the release of dopamine from rat nucleus accumbens measured by in vivo microdialysis. Eur J Pharmacol 261(1-2): 65-71.
21. Noble RE. 2003. Drug therapy in the elderly. Metabolism 52(10 Suppl 2): 27-30.
22. Paterniti S, Dufouil C, Alperovitch A. 2002. Long-term benzodiazepine use and cognitive decline in the elderly: the Epidemiology of Vascular Aging Study. J Clin Psychopharmacol 22(3): 285-293.
23. Petty F, Trivedi MH, Fulton M, Rush AJ. 1995. Benzodiazepines as antidepressants: does GABA play a role in depression? Biol Psychiatry 38(9): 578-591.
24. Rooijmans HG. 1999. Report of the Health Council on the use of benzodiazepines. The Netherlands Health Council. Ned Tijdschr Geneeskd 143(11): 551-552.
25. Shiah IS, Yatham LN. 1998. GABA function in mood disorders: an update and critical review. Life Sci 63(15): 1289-1303.
26. Simon GE, Ludman EJ. 2006. Outcome of new benzodiazepine prescriptions to older adults in primary care. Gen Hosp Psychiatry 28(5): 374-378.
27. Skoog I, Nilsson L, Palmertz B, et al. 1993. A population-based study of dementia in 85-year-olds. N Engl J Med 328(3): 153-158.
28. Sonnenberg CM, Beekman AT, Deeg DJ, van Tilburg V. 2003. Drug treatment in depressed elderly in the Dutch community. Int J Geriatr Psychiatry 18(2): 99-104.
29. Takada K, Murai T, Kanayama T, Koshikawa N. 1993. Effects of midazolam and flunitrazepam on the release of dopamine from rat striatum measured by in vivo microdialysis. Br J Anaesth 70(2): 181-185.
30. Turnheim K. 2004. Drug therapy in the elderly. Exp Gerontol 39(11-12): 1731-1738.
31. Valenstein M, Taylor KK, Austin K, et al. 2004. Benzodiazepine use among depressed patients treated in mental health settings. Am J Psychiatry 161(4): 654-661.
32. van der Elst W, van Boxtel MP, van Breukelen GJ, Jolles J. 2005. Rey's verbal learning test: normative data for 1855 healthy participants aged 24-81 years and the influence of age, sex, education, and mode of presentation. J Int Neuropsychol Soc 11(3): 290-302.
33. Vinkers DJ, Gussekloo J, Stek ML, et al. 2004. The 15-item Geriatric Depression Scale (GDS-15) detects changes in depressive symptoms after a major negative life event. The Leiden 85-plus Study. Int J Geriatr Psychiatry 19(1): 80-84.
34. Vinkers DJ, Gussekloo J, van der Mast RC, et al. 2003. Benzodiazepine use and risk of mortality in individuals aged 85 years or older. JAMA 290(22): 2942-2943.
35. Wetterling T, Junghanns K. 2004. Affective disorders in older inpatients. Int J Geriatr Psychiatry 19(5): 487-492.