No functional and transductional significance of specific neuropilin 1 siRNA inhibition in colon carcinoma cell lines lacking VEGF receptor 2

Oncology Reports

Volumn 21, Issue 5, 2009, Pages 1161-1168

  Quante, Michael ^a,b   Raskopf, Esther ^a   Stahl, Sebastian ^a   Vogt, Annabelle ^a   Sauerbruch, Tilman ^a   Schmitz, Volker ^a  

^a UNIVERSITY OF BONN   (Germany)

^b NewYork Presbyterian Hospital   (United States)

Author keywords

Molecular therapy; Neuropilin; siRNA; Tumorigenesis; VEGF

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROPILIN; NEUROPILIN 1; NEUROPILIN 2; PROTEIN KINASE B; SMALL INTERFERING RNA; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN D; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; COLON CARCINOGENESIS; COLON CARCINOMA; CONTROLLED STUDY; EX VIVO STUDY; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MALE; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; CELL LINE, TUMOR; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; HUMANS; MALE; MICE; MICE, SCID; NEUROPILIN-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 67649306615     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000336     Document Type: Article

References (28)

1. Ohlsson B and Palsson B: Follow-up after colorectal cancer surgery. Acta Oncol 42: 816-826, 2003.
2. Schmitz V, Kornek M, Hilbert T, et al: Treatment of metastatic colorectal carcinomas by systemic inhibition of vascular endothelial growth factor signaling in mice. World J Gastroenterol 11: 4332-4336, 2005.
3. Willett CG, Duda DG, Czito BG, Bendell JC, Clark JW and Jain RK: Targeted therapy in rectal cancer. Oncology 21: 1055-1065, 1075, 2007.
4. Duda DG, Jain RK and Willett CG: Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers. J Clin Oncol 25: 4033-4042, 2007.
5. Hanrahan V, Currie MJ, Gunningham SP, et al: The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression. J Pathol 200: 183-194, 2003.
6. Schmitz V, Vilanueva H, Raskopf E, et al: Increased VEGF levels induced by anti-VEGF treatment are independent of tumor burden in colorectal carcinomas in mice. Gene Ther 13: 1198-1205, 2006.
7. Fong GH, Rossant J, Gertsenstein M and Breitman ML: Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376: 66-70, 1995.
8. Takahashi Y, Kitadai Y, Bucana CD, Cleary KR, and Ellis LM: Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 55: 3964-3968, 1995.
9. Price DJ, Miralem T, Jiang S, Steinberg R, and Avraham H: Role of vascular endothelial growth factor in the stimulation of cellular invasion and signaling of breast cancer cells. Cell Growth Differ 12: 129-135, 2001.
10. Parikh AA, Fan F, Liu WB, et al: Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis. Am J Pathol 164: 2139-2151, 2004.
11. Guttmann-Raviv N, Kessler O, Shraga-Heled N, Lange T, Herzog Y and Neufeld G: The neuropilins and their role in tumorigenesis and tumor progression. Cancer Lett 231: 1-11, 2006.
12. Soker S, Takashima S, Miao HQ, Neufeld G and Klagsbrun M: Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92: 735-745, 1998.
13. Takashima S, Kitakaze M, Asakura M, et al: Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis. Proc Natl Acad Sci USA 99: 3657-3662, 2002.
14. Kitsukawa T, Shimono A, Kawakami A, Kondoh H and Fujisawa H: Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs. Development 121: 4309-4318, 1995.
15. Soker S: Neuropilin in the midst of cell migration and retraction. Int J Biochem Cell Biol 33: 433-437, 2001.
16. Miao HQ, Lee P, Lin H, Soker S and Klagsbrun M: Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression. FASEB J 14: 2532-2539, 2000.
17. Ochiumi T, Kitadai Y, Tanaka S, Akagi M, Yoshihara M and Chayama K: Neuropilin-1 is involved in regulation of apoptosis and migration of human colon cancer. Int J Oncol 29: 105-116, 2006.
18. Raskopf E, Dzienisowicz C, Hilbert T, et al: Effective angiostatic treatment in a murine metastatic and orthotopic hepatoma model. Hepatology 41: 1233-1240, 2005.
19. Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63, 1983.
20. Schmitz V, Raskopf E, Gonzalez-Carmona MA, et al: Plasminogen fragment K1-5 improves survival in a murine hepatocellular carcinoma model. Gut 56: 271-278, 2007.
21. Hansel DE, Wilentz RE, Yeo CJ, Schulick RD, Montgomery E and Maitra A: Expression of neuropilin-1 in high-grade dysplasia, invasive cancer, and metastases of the human gastrointestinal tract. Am J Surg Pathol 28: 347-356, 2004.
22. Pan Q, Chanthery Y, Liang WC, et al: Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell 11: 53-67, 2007.
23. Pan Q, Chathery Y, Wu Y, et al: Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting. J Biol Chem 282: 24049-24056, 2007.
24. Wang L, Dutta SK, Kojima T, et al: Neuropilin-1 modulates p53/ caspases axis to promote endothelial cell survival. PLoS ONE 2: e1161, 2007.
25. Kim DH, Longo M, Han Y, Lundberg P, Cantin E and Rossi JJ: Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nat Biotechnol 22: 321-325, 2004.
26. Marques JT, Devosse T, Wang D, et al: A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells. Nat Biotechnol 2: 559-565, 2006.
27. Judge AD, Sood V, Shaw JR, Fang D, McClintock K and MacLachlan I: Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol 23: 457-462, 2005.
28. Schlee M, Hornung V and Hartmann G: siRNA and isRNA: two edges of one sword. Mol Ther 14: 463-470, 2006.