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Volumn 116, Issue 2, 2009, Pages 273-279

Triple-negative breast cancers express receptors for growth hormone-releasing hormone (GHRH) and respond to GHRH antagonists with growth inhibition

Author keywords

Breast cancer; GHRH antagonist; Growth hormone releasing hormone; MAP kinase; Triple negative

Indexed keywords

ANTINEOPLASTIC AGENT; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE RELEASING FACTOR RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MZ J 7 118; UNCLASSIFIED DRUG;

EID: 67649225452     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-008-0120-4     Document Type: Article
Times cited : (27)

References (43)
  • 1
    • 33847063053 scopus 로고    scopus 로고
    • The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes
    • doi:10.1158/1078- 0432.CCR-06-1109
    • Carey LA, Dees EC, Sawyer L et al (2007) The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res 13:2329-2334. doi:10.1158/1078- 0432.CCR-06-1109
    • (2007) Clin Cancer Res , vol.13 , pp. 2329-2334
    • Carey, L.A.1    Dees, E.C.2    Sawyer, L.3
  • 2
    • 34547661993 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Clinical features and patterns of recurrence
    • doi:10.1158/1078-0432.CCR-06- 3045
    • Dent R, Trudeau M, Pritchard KI et al (2007) Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res 13:4429-4434. doi:10.1158/1078-0432.CCR-06- 3045
    • (2007) Clin Cancer Res , vol.13 , pp. 4429-4434
    • Dent, R.1    Trudeau, M.2    Pritchard, K.I.3
  • 3
    • 34247569300 scopus 로고    scopus 로고
    • Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)- negative, and HER2-negative invasive breast cancer, the socalled triple-negative phenotype: A population-based study from the California cancer registry
    • doi:10.1002/cncr.22618
    • Bauer KR, Brown M, Cress RD et al (2007) Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)- negative, and HER2-negative invasive breast cancer, the socalled triple-negative phenotype: a population-based study from the California cancer registry. Cancer 109:1721-1728. doi:10.1002/cncr.22618
    • (2007) Cancer , vol.109 , pp. 1721-1728
    • Bauer, K.R.1    Brown, M.2    Cress, R.D.3
  • 4
    • 34547860028 scopus 로고    scopus 로고
    • Differences in breast carcinoma characteristics in newly diagnosed African- American and Caucasian patients: A single-institution compilation compared with the national cancer institute's surveillance, epidemiology, and end results database
    • doi:10.1002/cncr.22836
    • Morris GJ, Naidu S, Topham AK et al (2007) Differences in breast carcinoma characteristics in newly diagnosed African- American and Caucasian patients: a single-institution compilation compared with the national cancer institute's surveillance, epidemiology, and end results database. Cancer 110:876-884. doi:10.1002/cncr.22836
    • (2007) Cancer , vol.110 , pp. 876-884
    • Morris, G.J.1    Naidu, S.2    Topham, A.K.3
  • 5
    • 33846266252 scopus 로고    scopus 로고
    • Prognostic markers in triple-negative breast cancer
    • doi:10.1002/cncr.22381
    • Rakha EA, El-Sayed ME, Green AR et al (2007) Prognostic markers in triple-negative breast cancer. Cancer 109:25-32. doi:10.1002/cncr.22381
    • (2007) Cancer , vol.109 , pp. 25-32
    • Rakha, E.A.1    El-Sayed, M.E.2    Green, A.R.3
  • 6
    • 34247381115 scopus 로고    scopus 로고
    • Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer
    • doi:10.1200/JCO.2006.06.5664
    • Haffty BG, Yang Q, Reiss M et al (2006) Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer. J Clin Oncol 24:5652-5657. doi:10.1200/JCO.2006.06.5664
    • (2006) J Clin Oncol , vol.24 , pp. 5652-5657
    • Haffty, B.G.1    Yang, Q.2    Reiss, M.3
  • 7
    • 34547982817 scopus 로고    scopus 로고
    • Use of immunohistochemical markers can refine prognosis in triple negative breast cancer
    • doi:10.1186/1471- 2407-7-134
    • Tischkowitz M, Brunet JS, Begin LR et al (2007) Use of immunohistochemical markers can refine prognosis in triple negative breast cancer. BMC Cancer 7:134. doi:10.1186/1471- 2407-7-134
    • (2007) BMC Cancer , vol.7 , pp. 134
    • Tischkowitz, M.1    Brunet, J.S.2    Begin, L.R.3
  • 8
    • 0034771199 scopus 로고    scopus 로고
    • Schally AV, Comaru-Schally AM, Nagy A et al (2001) Hypothalamic hormones and cancer. Front Neuroendocrinol 22:248-
    • Schally AV, Comaru-Schally AM, Nagy A et al (2001) Hypothalamic hormones and cancer. Front Neuroendocrinol 22:248-
  • 9
    • 67649208116 scopus 로고    scopus 로고
    • doi:10.1006/frne.2001.0217
    • doi:10.1006/frne.2001.0217
  • 10
    • 0033485288 scopus 로고    scopus 로고
    • Antagonistic analogs of growth hormone-releasing hormone: New potential antitumor agents
    • doi:10.1016/S1043- 2760(99)00209-X
    • Schally AV, Varga JL (1999) Antagonistic analogs of growth hormone-releasing hormone: new potential antitumor agents. Trends Endocrinol Metab 10:383-391. doi:10.1016/S1043- 2760(99)00209-X
    • (1999) Trends Endocrinol Metab , vol.10 , pp. 383-391
    • Schally, A.V.1    Varga, J.L.2
  • 11
    • 0033582289 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities
    • doi:10.1073/pnas.96.2.692
    • Varga JL, Schally AV, Csernus VJ et al (1999) Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities. Proc Natl Acad Sci USA 96:692-697. doi:10.1073/pnas.96.2.692
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 692-697
    • Varga, J.L.1    Schally, A.V.2    Csernus, V.J.3
  • 12
    • 1242342212 scopus 로고    scopus 로고
    • Increased activity of antagonists of growth hormone-releasing hormone substituted at positions 8, 9, and 10
    • doi:10.1073/pnas.0307288101
    • Varga JL, Schally AV, Horvath JE et al (2004) Increased activity of antagonists of growth hormone-releasing hormone substituted at positions 8, 9, and 10. Proc Natl Acad Sci USA 101:1708- 1713. doi:10.1073/pnas.0307288101
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1708-1713
    • Varga, J.L.1    Schally, A.V.2    Horvath, J.E.3
  • 13
    • 37349032876 scopus 로고    scopus 로고
    • Antagonists of growthhormone- releasing hormone: An emerging new therapy for cancer
    • doi:10.1038/ ncpendmet0677
    • Schally AV, Varga JL, Engel JB (2008) Antagonists of growthhormone- releasing hormone: an emerging new therapy for cancer. Nat Clin Pract Endocrinol Metab 4:33-43. doi:10.1038/ ncpendmet0677
    • (2008) Nat Clin Pract Endocrinol Metab , vol.4 , pp. 33-43
    • Schally, A.V.1    Varga, J.L.2    Engel, J.B.3
  • 14
    • 0034027068 scopus 로고    scopus 로고
    • Antagonists of growth hormone-releasing hormone arrest the growth of MDAMB- 468 estrogen-independent human breast cancers in nude mice
    • A:1006363230990, doi:10.1023
    • Kahan Z, Varga JL, Schally AV et al (2000) Antagonists of growth hormone-releasing hormone arrest the growth of MDAMB- 468 estrogen-independent human breast cancers in nude mice. Breast Cancer Res Treat 60:71-79. doi:10.1023/ A:1006363230990
    • (2000) Breast Cancer Res Treat , vol.60 , pp. 71-79
    • Kahan, Z.1    Varga, J.L.2    Schally, A.V.3
  • 15
    • 0033592985 scopus 로고    scopus 로고
    • Growth hormonereleasing hormone: An autocrine growth factor for small cell lung carcinoma
    • doi:10.1073/pnas.96.26.14894
    • Kiaris H, Schally AV, Varga JL et al (1999) Growth hormonereleasing hormone: an autocrine growth factor for small cell lung carcinoma. Proc Natl Acad Sci USA 96:14894-14898. doi:10.1073/pnas.96.26.14894
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14894-14898
    • Kiaris, H.1    Schally, A.V.2    Varga, J.L.3
  • 16
    • 0034772891 scopus 로고    scopus 로고
    • Inhibition of growth and metastases of MDA-MB-435 human estrogen-independent breast cancers by an antagonist of growth hormonereleasing hormone
    • doi:10.1097/ 00001813-200110000-00008
    • Chatzistamou I, Schally AV, Varga JL et al (2001) Inhibition of growth and metastases of MDA-MB-435 human estrogen-independent breast cancers by an antagonist of growth hormonereleasing hormone. Anticancer Drugs 12:761-768. doi:10.1097/ 00001813-200110000-00008
    • (2001) Anticancer Drugs , vol.12 , pp. 761-768
    • Chatzistamou, I.1    Schally, A.V.2    Varga, J.L.3
  • 17
    • 0034811213 scopus 로고    scopus 로고
    • Antagonists of GHRH decrease production of GH and IGF-I in MXT mouse mammary cancers and inhibit tumor growth
    • doi:10.1210/en.142.10.4371
    • Szepeshazi K, Schally AV, Armatis P et al (2001) Antagonists of GHRH decrease production of GH and IGF-I in MXT mouse mammary cancers and inhibit tumor growth. Endocrinology 142:4371-4378. doi:10.1210/en.142.10.4371
    • (2001) Endocrinology , vol.142 , pp. 4371-4378
    • Szepeshazi, K.1    Schally, A.V.2    Armatis, P.3
  • 18
    • 0032981091 scopus 로고    scopus 로고
    • Inhibition of growth, production of insulin-like growth factor-II (IGF-II), and expression of IGF-II mRNA of human cancer cell lines by antagonistic analogs of growth hormone-releasing hormone in vitro
    • doi:10.1073/ pnas.96.6.3098
    • Csernus VJ, Schally AV, Kiaris H et al (1999) Inhibition of growth, production of insulin-like growth factor-II (IGF-II), and expression of IGF-II mRNA of human cancer cell lines by antagonistic analogs of growth hormone-releasing hormone in vitro. Proc Natl Acad Sci USA 96:3098-3103. doi:10.1073/ pnas.96.6.3098
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3098-3103
    • Csernus, V.J.1    Schally, A.V.2    Kiaris, H.3
  • 19
    • 0034455291 scopus 로고    scopus 로고
    • Antagonists of growth hormone-releasing hormone and vasoactive intestinal peptide inhibit tumor proliferation by different mechanisms: Evidence from in vitro studies on human prostatic and pancreatic cancers
    • doi:10.1210/ en.141.6.2120
    • Rekasi Z, Varga JL, Schally AV et al (2000) Antagonists of growth hormone-releasing hormone and vasoactive intestinal peptide inhibit tumor proliferation by different mechanisms: evidence from in vitro studies on human prostatic and pancreatic cancers. Endocrinology 141:2120-2128. doi:10.1210/ en.141.6.2120
    • (2000) Endocrinology , vol.141 , pp. 2120-2128
    • Rekasi, Z.1    Varga, J.L.2    Schally, A.V.3
  • 20
    • 0037107433 scopus 로고    scopus 로고
    • Expression of mRNA for growth hormone-releasing hormone and splice variants of GHRH receptors in human malignant bone tumors
    • doi:10.1016/S0167-0115(02)00109-X
    • Busto R, Schally AV, Braczkowski R et al (2002) Expression of mRNA for growth hormone-releasing hormone and splice variants of GHRH receptors in human malignant bone tumors. Regul Pept 108:47-53. doi:10.1016/S0167-0115(02)00109-X
    • (2002) Regul Pept , vol.108 , pp. 47-53
    • Busto, R.1    Schally, A.V.2    Braczkowski, R.3
  • 21
    • 0037015018 scopus 로고    scopus 로고
    • The expression of growth hormone-releasing hormone (GHRH) and splice variants of its receptor in human gastroenteropancreatic carcinomas
    • doi:10.1073/ pnas.182433099
    • Busto R, Schally AV, Varga JL et al (2002) The expression of growth hormone-releasing hormone (GHRH) and splice variants of its receptor in human gastroenteropancreatic carcinomas. Proc Natl Acad Sci USA 99:11866-11871. doi:10.1073/ pnas.182433099
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11866-11871
    • Busto, R.1    Schally, A.V.2    Varga, J.L.3
  • 22
    • 0036680275 scopus 로고    scopus 로고
    • Inhibition of proliferation of PC-3 human prostate cancer by antagonists of growth hormone-releasing hormone: Lack of correlation with the levels of serum IGF-I and expression of tumoral IGF-II and vascular endothelial growth factor
    • doi:10.1002/pros.10105
    • Plonowski A, Schally AV, Letsch M et al (2002) Inhibition of proliferation of PC-3 human prostate cancer by antagonists of growth hormone-releasing hormone: lack of correlation with the levels of serum IGF-I and expression of tumoral IGF-II and vascular endothelial growth factor. Prostate 52:173-182. doi:10.1002/pros.10105
    • (2002) Prostate , vol.52 , pp. 173-182
    • Plonowski, A.1    Schally, A.V.2    Letsch, M.3
  • 23
    • 0034110139 scopus 로고    scopus 로고
    • Antagonists of growth hormone-releasing hormone (GH-RH) inhibit IGF-II production and growth of HT-29 human colon cancers
    • doi:10.1054/bjoc.2000.1223
    • Szepeshazi K, Schally AV, Groot K et al (2000) Antagonists of growth hormone-releasing hormone (GH-RH) inhibit IGF-II production and growth of HT-29 human colon cancers. Br J Cancer 82:1724-1731. doi:10.1054/bjoc.2000.1223
    • (2000) Br J Cancer , vol.82 , pp. 1724-1731
    • Szepeshazi, K.1    Schally, A.V.2    Groot, K.3
  • 24
    • 0033963319 scopus 로고    scopus 로고
    • Antagonists of growth hormone-releasing hormone (GH-RH) inhibit in vivo proliferation of experimental pancreatic cancers and decrease IGF-II levels in tumours
    • doi:10.1016/ S0959-8049(99)00230-0
    • Szepeshazi K, Schally AV, Groot K et al (2000) Antagonists of growth hormone-releasing hormone (GH-RH) inhibit in vivo proliferation of experimental pancreatic cancers and decrease IGF-II levels in tumours. Eur J Cancer 36:128-136. doi:10.1016/ S0959-8049(99)00230-0
    • (2000) Eur J Cancer , vol.36 , pp. 128-136
    • Szepeshazi, K.1    Schally, A.V.2    Groot, K.3
  • 25
    • 0034793313 scopus 로고    scopus 로고
    • Inhibition of growth and reduction in tumorigenicity of UCI-107 ovarian cancer by antagonists of growth hormone-releasing hormone and vasoactive intestinal peptide
    • Chatzistamou I, Schally AV, Varga JL et al (2001) Inhibition of growth and reduction in tumorigenicity of UCI-107 ovarian cancer by antagonists of growth hormone-releasing hormone and vasoactive intestinal peptide. J Cancer Res Clin Oncol 127:645- 652
    • (2001) J Cancer Res Clin Oncol , vol.127 , pp. 645-652
    • Chatzistamou, I.1    Schally, A.V.2    Varga, J.L.3
  • 26
    • 0035019832 scopus 로고    scopus 로고
    • Antagonists of growth hormone-releasing hormone and somatostatin analog RC- 160 inhibit the growth of the OV-1063 human epithelial ovarian cancer cell line xenografted into nude mice
    • doi:10.1210/jc.86.5.2144
    • Chatzistamou I, Schally AV, Varga JL et al (2001) Antagonists of growth hormone-releasing hormone and somatostatin analog RC- 160 inhibit the growth of the OV-1063 human epithelial ovarian cancer cell line xenografted into nude mice. J Clin Endocrinol Metab 86:2144-2152. doi:10.1210/jc.86.5.2144
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2144-2152
    • Chatzistamou, I.1    Schally, A.V.2    Varga, J.L.3
  • 27
    • 0019756333 scopus 로고
    • Ectopic production of growth hormone-releasing factor by carcinoid and pancreatic islet tumors associated with acromegaly
    • Frohman LA, Szabo M (1981) Ectopic production of growth hormone-releasing factor by carcinoid and pancreatic islet tumors associated with acromegaly. Prog Clin Biol Res 74:259-271
    • (1981) Prog Clin Biol Res , vol.74 , pp. 259-271
    • Frohman, L.A.1    Szabo, M.2
  • 28
    • 0033017622 scopus 로고    scopus 로고
    • Expression of growth hormone-releasing hormone (GHRH) messenger ribonucleic acid and the presence of biologically active GHRH in human breast, endometrial, and ovarian cancers
    • doi:10.1210/jc.84.2.582
    • Kahan Z, Arencibia JM, Csernus VJ et al (1999) Expression of growth hormone-releasing hormone (GHRH) messenger ribonucleic acid and the presence of biologically active GHRH in human breast, endometrial, and ovarian cancers. J Clin Endocrinol Metab 84:582-589. doi:10.1210/jc.84.2.582
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 582-589
    • Kahan, Z.1    Arencibia, J.M.2    Csernus, V.J.3
  • 29
    • 0035996854 scopus 로고    scopus 로고
    • Expression of growth hormone-releasing hormone (GHRH) and splice variants of GHRH receptors in human experimental prostate cancers
    • doi:10.1016/S0196-9781(02) 00043-8
    • Plonowski A, Schally AV, Busto R et al (2002) Expression of growth hormone-releasing hormone (GHRH) and splice variants of GHRH receptors in human experimental prostate cancers. Peptides 23:1127-1133. doi:10.1016/S0196-9781(02) 00043-8
    • (2002) Peptides , vol.23 , pp. 1127-1133
    • Plonowski, A.1    Schally, A.V.2    Busto, R.3
  • 30
    • 0037263411 scopus 로고    scopus 로고
    • The expression of growth hormone-releasing hormone (GHRH) and its receptor splice variants in human breast cancer lines; the evaluation of signaling mechanisms in the stimulation of cell proliferation
    • A:1021196504944, doi:10.1023
    • Garcia-Fernandez MO, Schally AV, Varga JL et al (2003) The expression of growth hormone-releasing hormone (GHRH) and its receptor splice variants in human breast cancer lines; the evaluation of signaling mechanisms in the stimulation of cell proliferation. Breast Cancer Res Treat 77:15-26. doi:10.1023/ A:1021196504944
    • (2003) Breast Cancer Res Treat , vol.77 , pp. 15-26
    • Garcia-Fernandez, M.O.1    Schally, A.V.2    Varga, J.L.3
  • 31
    • 10744228607 scopus 로고    scopus 로고
    • Antagonists of growth hormone-releasing hormone inhibit the proliferation of experimental non-small cell lung carcinoma
    • Szereday Z, Schally AV, Varga JL et al (2003) Antagonists of growth hormone-releasing hormone inhibit the proliferation of experimental non-small cell lung carcinoma. Cancer Res 63:7913-7919
    • (2003) Cancer Res , vol.63 , pp. 7913-7919
    • Szereday, Z.1    Schally, A.V.2    Varga, J.L.3
  • 32
    • 0036776259 scopus 로고    scopus 로고
    • Expression of growth hormone-releasing hormone and its receptor splice variants in human prostate cancer
    • doi:10.1210/jc.2002-020347
    • Halmos G, Schally AV, Czompoly T et al (2002) Expression of growth hormone-releasing hormone and its receptor splice variants in human prostate cancer. J Clin Endocrinol Metab 87:4707- 4714. doi:10.1210/jc.2002-020347
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 4707-4714
    • Halmos, G.1    Schally, A.V.2    Czompoly, T.3
  • 33
    • 0031031625 scopus 로고    scopus 로고
    • Somatostatin and growth hormone-releasing hormone in normal and tumoral human breast tissue: Endogenous content, in vitro pulsatile release, and regulation
    • doi:10.1210/jc.82.2.690
    • Benlot C, Levy L, Fontanaud P et al (1997) Somatostatin and growth hormone-releasing hormone in normal and tumoral human breast tissue: endogenous content, in vitro pulsatile release, and regulation. J Clin Endocrinol Metab 82:690-696. doi:10.1210/jc.82.2.690
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 690-696
    • Benlot, C.1    Levy, L.2    Fontanaud, P.3
  • 34
    • 0034641750 scopus 로고    scopus 로고
    • Isolation and sequencing of cDNAs for splice variants of growth hormonereleasing hormone receptors from human cancers
    • doi:10.1073/pnas.180313297
    • Rekasi Z, Czompoly T, Schally AV et al (2000) Isolation and sequencing of cDNAs for splice variants of growth hormonereleasing hormone receptors from human cancers. Proc Natl Acad Sci USA 97:10561-10566. doi:10.1073/pnas.180313297
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10561-10566
    • Rekasi, Z.1    Czompoly, T.2    Schally, A.V.3
  • 35
    • 0034641699 scopus 로고    scopus 로고
    • Human renal cell carcinoma expresses distinct binding sites for growth hormonereleasing hormone
    • doi:10.1073/pnas.180313097
    • Halmos G, Schally AV, Varga JL et al (2000) Human renal cell carcinoma expresses distinct binding sites for growth hormonereleasing hormone. Proc Natl Acad Sci USA 97:10555-10560. doi:10.1073/pnas.180313097
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10555-10560
    • Halmos, G.1    Schally, A.V.2    Varga, J.L.3
  • 36
    • 0034797098 scopus 로고    scopus 로고
    • A potential autocrine pathway for growth hormone releasing hormone (GHRH) and its receptor in human prostate cancer cell lines
    • doi:10.1002/pros.1125
    • Chopin LK, Herington AC (2001) A potential autocrine pathway for growth hormone releasing hormone (GHRH) and its receptor in human prostate cancer cell lines. Prostate 49:116-121. doi:10.1002/pros.1125
    • (2001) Prostate , vol.49 , pp. 116-121
    • Chopin, L.K.1    Herington, A.C.2
  • 37
    • 0037156945 scopus 로고    scopus 로고
    • Effective treatment of experimental U-87MG human glioblastoma in nude mice with a targeted cytotoxic bombesin analogue, AN-215
    • doi:10.1038/sj.bjc.6600235
    • Szereday Z, Schally AV, Nagy A et al (2002) Effective treatment of experimental U-87MG human glioblastoma in nude mice with a targeted cytotoxic bombesin analogue, AN-215. Br J Cancer 86:1322-1327. doi:10.1038/sj.bjc.6600235
    • (2002) Br J Cancer , vol.86 , pp. 1322-1327
    • Szereday, Z.1    Schally, A.V.2    Nagy, A.3
  • 38
    • 0034060312 scopus 로고    scopus 로고
    • Increase in mRNA concentrations of pituitary receptors for growth hormonereleasing hormone and growth hormone secretagogues after neonatal monosodium glutamate treatment
    • doi:10.1046/j.1365-2826.2000.00458.x
    • Kovacs M, Kineman RD, Schally AV et al (2000) Increase in mRNA concentrations of pituitary receptors for growth hormonereleasing hormone and growth hormone secretagogues after neonatal monosodium glutamate treatment. J Neuroendocrinol 12:335-341. doi:10.1046/j.1365-2826.2000.00458.x
    • (2000) J Neuroendocrinol , vol.12 , pp. 335-341
    • Kovacs, M.1    Kineman, R.D.2    Schally, A.V.3
  • 39
    • 0037039396 scopus 로고    scopus 로고
    • Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs
    • doi:10.1073/pnas.012590999
    • Kiaris H, Schally AV, Busto R et al (2002) Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs. Proc Natl Acad Sci USA 99:196-200. doi:10.1073/pnas.012590999
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 196-200
    • Kiaris, H.1    Schally, A.V.2    Busto, R.3
  • 40
    • 33745863668 scopus 로고    scopus 로고
    • Autocrine/paracrine regulation of breast cancer cell proliferation by growth hormone releasing hormone via Ras, Raf, and mitogen-activated protein kinase
    • doi:10.1210/ me.2005-0001
    • Siriwardana G, Bradford A, Coy D et al (2006) Autocrine/paracrine regulation of breast cancer cell proliferation by growth hormone releasing hormone via Ras, Raf, and mitogen-activated protein kinase. Mol Endocrinol 20:2010-2019. doi:10.1210/ me.2005-0001
    • (2006) Mol Endocrinol , vol.20 , pp. 2010-2019
    • Siriwardana, G.1    Bradford, A.2    Coy, D.3
  • 41
    • 28444478741 scopus 로고    scopus 로고
    • The expression of the pituitary growth hormone-releasing hormone receptor and its splice variants in normal and neoplastic human tissues
    • doi:10.1073/pnas.0506844102
    • Havt A, Schally AV, Halmos G et al (2005) The expression of the pituitary growth hormone-releasing hormone receptor and its splice variants in normal and neoplastic human tissues. Proc Natl Acad Sci USA 102:17424-17429. doi:10.1073/pnas.0506844102
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 17424-17429
    • Havt, A.1    Schally, A.V.2    Halmos, G.3
  • 42
    • 4744362859 scopus 로고    scopus 로고
    • Immunohistochemical detection of GHRH and its receptor splice variant 1 in primary human breast cancers
    • doi:10.1530/eje.0.1510391
    • Chatzistamou I, Schally AV, Kiaris H et al (2004) Immunohistochemical detection of GHRH and its receptor splice variant 1 in primary human breast cancers. Eur J Endocrinol 151:391-396. doi:10.1530/eje.0.1510391
    • (2004) Eur J Endocrinol , vol.151 , pp. 391-396
    • Chatzistamou, I.1    Schally, A.V.2    Kiaris, H.3
  • 43
    • 33846909946 scopus 로고    scopus 로고
    • Potentiation of mammary cancer inhibition by combination of antagonists of growth hormone-releasing hormone with docetaxel
    • doi:10.1073/pnas.0610860104
    • Buchholz S, Schally AV, Engel JB et al (2007) Potentiation of mammary cancer inhibition by combination of antagonists of growth hormone-releasing hormone with docetaxel. Proc Natl Acad Sci USA 104:1943-1946. doi:10.1073/pnas.0610860104
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 1943-1946
    • Buchholz, S.1    Schally, A.V.2    Engel, J.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.