Increased activity of antagonists of growth hormone-releasing hormone substituted at positions 8, 9, and 10

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 6, 2004, Pages 1708-1713

  Varga, Jozsef L ^a   Schally, Andrew V ^a   Horvath, Judit E ^a,b   Kovacs, Magdolna ^a,b   Halmos, Gabor ^a   Groot, Kate ^a   Toller, Gabor L ^a,b   Rekasi, Zoltan ^a,b   Zarandi, Marta ^a,c  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PÉCS   (Hungary)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 AMIDINOPHENYLALANINE; 1,4 AMINOPHENYLALANINE; 2 AMINOBUTYRIC ACID; 3,3' DIPHENYLALANINE 10,2 NAPHTHYLALANINE; ACETIC ACID DERIVATIVE; ALANINE DERIVATIVE; AMIDE; AMIDINOPHENYLALANINE; AMINO ACID; ARGININE; CITRULLINE; CYCLOHEXYLALANINE; FENCLONINE; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE RELEASING FACTOR ANTAGONIST; GROWTH HORMONE RELEASING FACTOR RECEPTOR; HISTIDINE; HOMOARGININE; HORMONE ANTAGONIST; METHYL GROUP; NAPHTHYL GROUP; NORLEUCINE; O ETHYLTYROSINE; PEPTIDE; PHENYL GROUP; PHENYLALANINE DERIVATIVE; TYROSINE; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CANCER INHIBITION; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENDOCRINE SYSTEM; GROWTH HORMONE RELEASE; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; MALE; MALIGNANT NEOPLASTIC DISEASE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; RAT; RECEPTOR BINDING; TUMOR XENOGRAFT;

ANIMALS; GROWTH HORMONE; GROWTH HORMONE-RELEASING HORMONE; PITUITARY GLAND; RATS;

ANIMALIA; MUS MUSCULUS;

EID: 1242342212     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0307288101     Document Type: Article

References (26)

1. Schally, A. V. & Varga, J. L. (1999) Trends Endocrinol. Metab. 10, 383-391.
2. Schally, A. V., Comaru-Schally, A. M., Nagy, A., Kovacs, M., Szepeshazi, K., Plonowski, A., Varga, J. L. & Halmos, G. (2001) Front. Neuroendocrinol. 22, 248-291.
3. Jaffe, C. A., DeMott-Friberg, R., Frohman, L. A. & Barkan, A. L. (1997) J. Clin. Endocrinol. Metab. 82, 634-637.
4. Varga, J. L., Schally, A. V., Csernus, V. J., Zarandi, M., Halmos, G., Groot, K. & Rekasi, Z. (1999) Proc. Natl. Acad. Sci. USA 96, 692-697.
5. Zarandi, M., Horvath, J. E., Halmos, G., Pinski, J., Nagy, A., Groot, K., Rekasi, Z. & Schally, A. V. (1994) Proc. Natl. Acad. Sci. USA 91, 12298-12302.
6. Zarandi, M., Kovacs, M., Horvath, J. E., Toth, K., Halmos, G., Groot, K., Nagy, A., Kele, Z. & Schally, A. V. (1997) Peptides 18, 423-430.
7. Robberecht, P., Coy, D. H., Waelbroeck, M., Heiman, M. L., deNeef, P., Camus, J.-C. & Christophe, J. (1985) Endocrinology 117, 1759-1764.
8. Sato, K., Hotta, M., Kageyama, J., Hu, H.-Y., Dong, M.-H. & Ling, N. (1990) Biochem. Biophys. Res. Commun. 167, 360-366.
9. Coy, D. H., Hocart, S. J. & Murphy, W. A. (1991) Eur. J. Pharmacol. 204, 179-185.
10. Gaudreau, L. L. P. (1994) Neuroendocrinology 59, 363-370.
11. Campbell, R. M., Bongers, J. & Felix, A. M. (1995) Biopolymers 37, 67-88.
12. Cervini, L. A., Donaldson, C. J., Koerber, S. C., Vale, W. W. & Rivier, J. E. (1998) J. Med. Chem. 41, 717-727.
13. Izdebski, J., Witkowska, E., Kunce, D., Orlowska, A., Baranowska, B., Radzikowska, M. & Smoluch, M. (2002) J. Peptide Sci. 8, 289-296.
14. Halmos, G., Schally, A. V., Varga, J. L., Plonowski, A., Rekasi, Z. & Czompoly, T. (2000) Proc. Natl. Acad. Sci. USA 97, 10555-10560.
15. Rekasi, Z., Czompoly, T., Schally, A. V. & Halmos, G. (2000) Proc. Natl. Acad. Sci. USA 97, 10561-10566.
16. Kiaris, H., Schally, A. V., Busto, R., Halmos, G., Artavanis-Tsakonas, S. & Varga, J. L. (2002) Proc. Natl. Acad. Sci. USA 99, 196-200.
17. Kates, S. A., de la Torre, B. G., Eritja, R. & Albericio, F. (1994) Tetrahedron Lett. 35, 1033-1034.
18. Csernus, V. J. & Schally, A. V. (1991) in Neuroendocrine Research Methods, ed. Greenstein, B. D. (Harwood, London), pp. 71-109.
19. Rekasi, Z. & Schally, A. V. (1993) Proc. Natl. Acad. Sci. USA 90, 2146-2149.
20. Halmos, G., Rekasi, Z., Szoke, B. & Schally, A. V. (1993) Receptor 3, 87-97.
21. McPherson, G. A. (1985) J. Pharmacol. Methods 14, 213-228.
22. Kaiser, E. T. & Kezdy, F. J. (1984) Science 223, 249-255.
23. Norinder, U., Rivera, C. & Unden, A. (1997) J. Peptide Res. 49, 155-162.
24. Bongers, J., Heimer, E. P., Lambros, T., Pan, Y.-C. E., Campbell, R. M. & Felix, A. M. (1992) Int. J. Peptide Protein Res. 39, 364-374.
25. Kanashiro, C. A., Schally, A. V., Groot, K., Armatis, P., Bernardino, A. L. F. & Varga, J. L. (2003) Proc. Natl. Acad. Sci. USA 100, 15836-15841.
26. Szepeshazi, K., Schally, A. V., Armatis, P., Groot, K., Hebert, F., Feil, A., Varga, J. L. & Halmos, G. (2001) Endocrinology 142, 4371-4378.