Antagonists of growth hormone-releasing hormone arrest the growth of MDA-MB-468 estrogen-independent human breast cancers in nude mice

Breast Cancer Research and Treatment

Volumn 60, Issue 1, 2000, Pages 71-79

  Kahán, Zsuzsanna ^a,b   Varga, József L ^a,b   Schally, Andrew V ^a,b   Rékási, Zoltán ^a,b   Armatis, Patricia ^a   Chatzistamou, Ioulia ^a,b   Czömpöly, Tamás ^a,b   Halmos, Gábor ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Breast cancer; GH RH; Growth hormone releasing hormone (GH RH) antagonists; IGF I; IGF I receptor

Indexed keywords

ANTINEOPLASTIC AGENT; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE RELEASING FACTOR ANTAGONIST; INSULIN; JV 1 36; MESSENGER RNA; MZ 5 156; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; BREAST CANCER; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR REGRESSION; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; BREAST NEOPLASMS; DISEASE MODELS, ANIMAL; DNA PRIMERS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GROWTH HORMONE-RELEASING HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; MICE; MICE, NUDE; RADIOIMMUNOASSAY; RECEPTOR, IGF TYPE 1; RECEPTORS, NEUROPEPTIDE; RECEPTORS, PITUITARY HORMONE-REGULATING HORMONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERMORELIN; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0034027068     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006363230990     Document Type: Article

References (40)

1. 1. Schally AV, Varga JL: Antagonistic analogs of growth hormone-releasing hormone (GH-RH): New potential antitumor agents. Trends Endocrinol Metab 10: 383-391, 1999
2. 2. Pinski J, Schally AV, Groot K, Halmos G, Szepeshazi K. Zarándi M, Armatis P: Inhibition of growth of human osteosarcomas by antagonists of growth hormone-releasing hormone. J Natl Cancer Inst 87: 1787-1794, 1995
3. 3. Pinski J, Schally AV, Jungwirth A, Groot K, Halmos G, Armatis P, Zarándi M, Vadillo-Buenfil M: Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone. Int J Oncol 9: 1099-1105, 1996
4. 4. Jungwirth A, Schally AV, Pinski J, Halmos G, Groot K, Armatis P, Vadillo-Buenfil M: Inhibition of in vivo proliferation of androgen-independent prostate cancers by an antagonist of growth hormone-releasing hormone. Br J Cancer 75: 1585-1592, 1997
5. 5. Jungwirth A, Schally AV, Pinski J, Groot K, Armatis P, Halmos G: Growth hormone-releasing hormone antagonist MZ-4-71 inhibits in vivo proliferation of CAKI-I renal adenocarcinoma. Proc Natl Acad Sci USA 94: 5810-5813, 1997
6. 6. Lamharzi N, Schally AV, Koppán M, Groot K: Growth hormone-releasing antagonist MZ-5-156 inhibits growth of DU-145 human androgen-independent prostate carcinoma in nude mice and suppresses the levels and mRNA expression of insulin-like growth factor II in tumors. Proc Natl Acad Sci USA 95: 8864-8868, 1998
7. 7. Kiaris H, Schally AV: Decrease in telomerase activity in U87MG human glioblastomas after treatment with an antagonist of growth hormone-releasing hormone. Proc Natl Acad Sci USA 96: 226-231, 1999
8. 8. Szepeshazi K, Schally AV, Groot K, Armatis P, Hebert F, Halmos G: Antagonists of growth hormone-releasing hormone (GH-RH) inhibit in vivo proliferation of experimental pancreatic cancers and decrease IGF-II levels in tumors. Eur J Cancer (in press), 2000
9. 9. Csernus VJ, Schally AV, Kiaris H, Armatis P: Inhibition of growth, production of insulin-like growth factor-II (IGF-II), and expression of IGF-II mRNA of human cancer cell lines by antagonistic analogs of growth hormone-releasing hormone in vitro. Proc Natl Acad Sci USA 96: 3098-3103, 1999
10. 10. Lippman ME, Dickson RB, Gelmann EP, Rosen N, Knabbe C, Bates S, Bronzert D, Huff K, Kasid A: Growth regulatory peptide production by human breast carcinoma cells. J Steroid Biochem 29: 79-88, 1988
11. 11. Rasmussen AA, Cullen KJ: Paracrine/autocrine regulation of breast cancer by the insulin-like growth factors. Breast Cancer Res Treat 47: 219-233, 1998
12. 12. Pollak MN, Perdue JF, Margolese RG, Baer K, Richard M: Presence of somatomedin receptors on primary human breast and colon carcinomas. Cancer Lett 38: 223-230, 1987
13. 13. Lee AV, Hilsenbeck SG, Yee D: IGF system components as prognostic markers in breast cancer. Breast Cancer Res Treat 47: 295-302, 1998
14. 14. Pollak MN: Endocrine effects of IGF-I on normal and transformed breast epithelial cells: potential relevance to strategies for breast cancer treatment and prevention. Breast Cancer Res Treat 47: 209-217, 1998
15. 15. Hankinson SE, Willett WC, Colditz GA, Hunter DJ, Michaud DS, Deroo B, Rosner B, Speizer FE, Pollak M: Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 351: 1393-1396, 1998
16. 16. Osborne CK, Coronado EB, Kitten LJ, Arteaga CI, Fuqua SAW, Ramasharma K, Marshall M, Li CH: Insulin-like growth factor-II (IGF-II): a potential autocrine/paracrine growth factor for human breast cancer acting via IGF-I receptor. Mol Endocrinol 3: 1701-1709, 1989
17. 17. Yee D, Cullen KJ, Paik S, Perdue JF, Hampton B, Schwartz A, Lippman ME, Rosen N: Insulin-like growth factor II mRNA expression in human breast cancer. Cancer Res 48: 6691-6696, 1988
18. 18. Singer C, Rasmussen A, Smith HS, Lippman ME, Lynch HT, Cullen KJ: Malignant breast epithelium selects for insulin-like growth factor II expression in breast stroma: Evidence for paracrine function. Cancer Res 55: 2448-2454, 1995
19. 19. Olivecrona H, Hilding A, Ekström C, Barle H, Nyberg B, Möller C, Delhanty PJ, Baxter RC, Angelin B, Ekström TJ, Tally M: Acute and short-term effects of growth hormone on insulin-like growth factors and their binding proteins: serum levels and hepatic messenger ribonucleic acid responses in humans. J Clin Endocrinol Metab 84: 553-560, 1999
20. 20. Christofides ND, Stephanou A, Suzuki H, Yiangou Y, Bloom SR: Distribution of immunoreactive growth hormone-releasing hormone in the human brain and intestine and its production by tumors. J Clin Endocrinol Metab 59: 747-751, 1984
21. 21. Bagnato A, Moretti C, Ohnishi J, Frajese G, Catt KJ: Expression of the growth hormone-releasing hormone gene and its product in the rat ovary. Endocrinology 130: 1097-1102, 1992
22. 22. Matsubara S, Sato M, Mizobuchi M, Niimi M, Takahara J: Differential gene expression of growth hormone (GH)-releasing hormone (GRH) and GRH receptor in various rat tissues. Endocrinology 136:4147-4150, 1995
23. 23. Monts BS, Breyer PR, Rothrock JK, Pescovitz OH: Peptides of the growth hormone-releasing hormone family. Differential expression in rat testis. Endocrine 4: 73-78, 1996
24. 24. Bagnato A, Moretti C, Frajese G., Catt KJ: Gonadotropin-induced expression of receptors for growth hormone releasing factor in cultured granulosa cells. Endocrinology 128: 2889-2894, 1991
25. 25. Srivastava CH, Kelley MR, Monts BS, Wilson TM, Breyer PR, Peskovitz OH: Growth hormone-releasing hormone receptor mRNA is present in rat testis. Endocrine 2: 607-610, 1994
26. 26. Mayo KE, Miller TL, DeAlmeida V, Zheng J, Godfrey PA: The growth-hormone-releasing hormone receptor: signal transduction, gene expression, and physiological function in growth regulation. Ann N Y Acad Sci 805: 184-203, 1996
27. 27. Frohman LA, Szabo M: Ectopic production of growth hormone-releasing factor by carcinoid and pancreatic islet tumors associated with acromegaly. Prog Clin Biol Res 74: 259-271, 1981
28. 28. Losa M, Wolfram G, Mojto J, Schopohl Y, Spiess R, Huber O, Muller A, von Werder K: 1990 Presence of growth hormone-releasing hormone-like immunoreactivily in human tumors: Characterization of immunological and biological properties. J Clin Endocrinol Metab 70: 62-68, 1990
29. 29. Kahán Z, Arencibia JM, Csernus VJ, Groot K, Kineman RD, Robinson WR, Schally AV: Expression of growth hormone releasing-hormone (GH-RH) messenger ribonucleic acid and the presence of biologically active GH-RH in human breast, endometrial, and ovarian cancers. J Clin Endocrinol Metab 84: 582-589, 1999
30. 30. Benlot C, Lévy L, Fontanaud P, Roche A, Rouannet P, Joubert D: Somatostatin and growth hormone-releasing hormone in normal and tumoral human breast tissue: endogenous content, in vitro pulsatile release, and regulation. J Clin Endocrinol Metab 82: 690-696, 1997
31. 31. Zarándi M, Kovacs M, Horvath JE, Toth K, Halmos G, Groot K, Nagy A, Kele Z, Schally AV: Synthesis and in vitro evaluation of new potent antagonists of growth hormone-releasing hormone (GH-RH). Peptides 18: 423-430, 1997
32. 32. Varga JL, Schally AV, Csernus VJ, Zarándi M, Halmos G, Groot K, Rékási Z: Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities. Proc Natl Acad Sci USA 96: 692-697, 1999
33. 33. Sepp-Lorenzino L, Rosen N, Lebwohl DE: Insulin and insulin-like growth factor signaling are defective in the MDA-MB-468 human breast cancer cell line. Cell Growth & Differ 5: 1077-1083, 1994
34. 34. Izdebski J, Pinksi J, Horvath JE, Halmos g, Groot K, Schally AV: Synthesis and biological evaluation of superactive agonists of growth hormone-releasing hormone. Proc Natl Acad Sci USA 92: 4872-4876, 1995
35. 35. Plumb JA, Milroy R, Kaye SB: Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetra zolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay. Cancer Res 49: 4435-4440, 1989
36. 36. Halmos G, Rekasi Z, Szoke B, Schally AV: Use of radioreceptor assay and cell superfusion system for in vitro screening of analogs of growth hormone-releasing hormone. Receptor 3: 87-97, 1993
37. 37. Munson PJ, Rodbard D: A versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107: 220-239, 1980
38. 38. Voutilainen R, Franks S, Mason HD, Martikainen H: Expression of insulin-like growth factor (IGF), IGF-binding protein, and IGF receptor messenger ribonucleic acids in normal and polycystic ovaries. J Clin Endocrinol Metab 81: 1003-1008, 1996
39. 39. Murabe H, Shimatsu A, Ihara C, Mizuta H, Nakamura Y, Nagata I, Kikuchi H, Nakao K: Expression of somatostatin receptor (SSTR) subtypes in pituitary adenomas: Quantitative analysis of SSTR2 mRNA by reverse transcription-polymerase chain reaction. J Neuroendocrinol 8: 605-610, 1996
40. 40. Murata T, Takizawa T, Funaba M, Fujimura H, Murata E, Torii K: Quantitation of mouse and rat beta-actin mRNA by competitive polymerase chain reaction using capillary electrophoresis. Anal Biochem 244: 172-174, 1997