메뉴 건너뛰기




Volumn 36, Issue 1, 2000, Pages 128-136

Antagonists of growth hormone-releasing hormone (GH-RH) inhibit in vivo proliferation of experimental pancreatic cancers and decrease IGF-II levels in tumours

Author keywords

AgNOR; GH RH antagonists; IGF I; IGF I receptor; IGF II; Pancreatic cancer

Indexed keywords

GONADORELIN ANTAGONIST; MZ 4 71; MZ 5 156; NITROSAMINE; SOMATOMEDIN B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

EID: 0033963319     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(99)00230-0     Document Type: Article
Times cited : (60)

References (44)
  • 2
    • 0029988659 scopus 로고    scopus 로고
    • Surgical management of pancreatic carcinoma
    • McGrath P.C., Sloan D.A., Kenady D.E. Surgical management of pancreatic carcinoma. Semin. Oncol. 23:1996;200-213.
    • (1996) Semin. Oncol. , vol.23 , pp. 200-213
    • McGrath, P.C.1    Sloan, D.A.2    Kenady, D.E.3
  • 3
    • 0029040131 scopus 로고
    • No standard treatment is available for advanced pancreatic cancer
    • Lionetto R., Pugliese V., Bruzzi P., Rosso R. No standard treatment is available for advanced pancreatic cancer. Eur. J. Cancer. 31A:1995;882-887.
    • (1995) Eur. J. Cancer , vol.31 , pp. 882-887
    • Lionetto, R.1    Pugliese, V.2    Bruzzi, P.3    Rosso, R.4
  • 5
    • 0028352250 scopus 로고
    • Hypothalamic hormones: From neuroendocrinology to cancer therapy
    • Schally A.V. Hypothalamic hormones. from neuroendocrinology to cancer therapy Anti-Cancer Drugs. 5:1994;115-130.
    • (1994) Anti-Cancer Drugs , vol.5 , pp. 115-130
    • Schally, A.V.1
  • 6
    • 0032821184 scopus 로고    scopus 로고
    • Growth inhibition of experimental pancreatic cancers and sustained reduction of epidermal growth factor receptors during therapy with hormonal peptide analogues
    • Szepeshazi K, Halmos G, Schally AV, et al. Growth inhibition of experimental pancreatic cancers and sustained reduction of epidermal growth factor receptors during therapy with hormonal peptide analogues. J Cancer Res Clin Oncol 1999, 125, 444-452.
    • (1999) J Cancer Res Clin Oncol , vol.125 , pp. 444-452
    • Szepeshazi, K.1    Halmos, G.2    Schally, A.V.3
  • 7
    • 0029944291 scopus 로고    scopus 로고
    • Induction and involvement of endogenous IGF-I in pancreas regeneration after partial pancreatectomy in the dog
    • Hayakawa H., Kawarada Y., Mizumoto R., Hibasami H., Tanaka M., Nakashima K. Induction and involvement of endogenous IGF-I in pancreas regeneration after partial pancreatectomy in the dog. J. Endocrinol. 149:1996;259-267.
    • (1996) J. Endocrinol. , vol.149 , pp. 259-267
    • Hayakawa, H.1    Kawarada, Y.2    Mizumoto, R.3    Hibasami, H.4    Tanaka, M.5    Nakashima, K.6
  • 8
    • 0028997487 scopus 로고
    • Insulin-like growth factor I overexpression in human pancreatic cancer: Evidence for autocrine and paracrine roles
    • Bergmann U., Funatomi H., Yokoyama M., Berger H.G., Korc M. Insulin-like growth factor I overexpression in human pancreatic cancer. evidence for autocrine and paracrine roles Cancer Res. 55:1995;2007-2011.
    • (1995) Cancer Res. , vol.55 , pp. 2007-2011
    • Bergmann, U.1    Funatomi, H.2    Yokoyama, M.3    Berger, H.G.4    Korc, M.5
  • 9
    • 0028356419 scopus 로고
    • A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis
    • Christofori G., Naik P., Hanahan D. A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature. 369:1994;414-417.
    • (1994) Nature , vol.369 , pp. 414-417
    • Christofori, G.1    Naik, P.2    Hanahan, D.3
  • 10
    • 0029788198 scopus 로고    scopus 로고
    • Insulin-like growth factor II activates mitogenic signaling in pancreatic cancer cells via IRS-1: In vivo evidence for an islet-cancer cell axis
    • Bergmann U., Funatomi H., Kornmann M., Ishiwata T., Berger H.G., Korc M. Insulin-like growth factor II activates mitogenic signaling in pancreatic cancer cells via IRS-1. in vivo evidence for an islet-cancer cell axis Int. J. Oncol. 9:1996;487-492.
    • (1996) Int. J. Oncol. , vol.9 , pp. 487-492
    • Bergmann, U.1    Funatomi, H.2    Kornmann, M.3    Ishiwata, T.4    Berger, H.G.5    Korc, M.6
  • 11
    • 0029119731 scopus 로고
    • Biology of disease. Insulin-like growth factor-I receptor
    • Rubin R., Baserga R. Biology of disease. Insulin-like growth factor-I receptor. Lab. Invest. 73:1995;311-331.
    • (1995) Lab. Invest. , vol.73 , pp. 311-331
    • Rubin, R.1    Baserga, R.2
  • 12
    • 0028958031 scopus 로고
    • Insulin-like growth factors and their binding proteins: Biological actions
    • Jones J.I., Clemmons D.R. Insulin-like growth factors and their binding proteins. biological actions Endocrine Rev. 16:1995;3-34.
    • (1995) Endocrine Rev. , vol.16 , pp. 3-34
    • Jones, J.I.1    Clemmons, D.R.2
  • 13
    • 0031009876 scopus 로고    scopus 로고
    • Synthesis and in vitro evaluation of new potent antagonists of growth hormone-releasing hormone (GH-RH)
    • Zarandi M., Kovacs M., Horvath J.E.et al. Synthesis and in vitro evaluation of new potent antagonists of growth hormone-releasing hormone (GH-RH). Peptides. 18:1997;423-430.
    • (1997) Peptides , vol.18 , pp. 423-430
    • Zarandi, M.1    Kovacs, M.2    Horvath, J.E.3
  • 14
    • 0028882017 scopus 로고
    • Inhibition of growth of human osteosarcomas by antagonists of growth hormone-releasing hormone
    • Pinski J., Schally A.V., Groot K.et al. Inhibition of growth of human osteosarcomas by antagonists of growth hormone-releasing hormone. J. Natl. Cancer Inst. 87:1995;1787-1794.
    • (1995) J. Natl. Cancer Inst. , vol.87 , pp. 1787-1794
    • Pinski, J.1    Schally, A.V.2    Groot, K.3
  • 15
    • 0029807034 scopus 로고    scopus 로고
    • Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH)
    • Pinski J., Schally A.V., Jungwirth A.et al. Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH). Int. J. Oncol. 9:1996;1099-1105.
    • (1996) Int. J. Oncol. , vol.9 , pp. 1099-1105
    • Pinski, J.1    Schally, A.V.2    Jungwirth, A.3
  • 16
    • 0030979558 scopus 로고    scopus 로고
    • Inhibition of in vivo proliferation of androgen-independent prostate cancers by an antagonist of growth hormone-releasing hormone
    • Jungwirth A., Schally A.V., Pinski J.et al. Inhibition of in vivo proliferation of androgen-independent prostate cancers by an antagonist of growth hormone-releasing hormone. Br. J. Cancer. 17:1997;1585-1592.
    • (1997) Br. J. Cancer , vol.17 , pp. 1585-1592
    • Jungwirth, A.1    Schally, A.V.2    Pinski, J.3
  • 17
    • 0025308907 scopus 로고
    • Inhibitory effects of analogs of luteinizing hormone-releasing hormone and somatostatin on pancreatic cancers in hamsters
    • Szende B., Srkalovic G., Schally A.V., Lapis K., Groot K. Inhibitory effects of analogs of luteinizing hormone-releasing hormone and somatostatin on pancreatic cancers in hamsters. Cancer. 65:1990;2279-2290.
    • (1990) Cancer , vol.65 , pp. 2279-2290
    • Szende, B.1    Srkalovic, G.2    Schally, A.V.3    Lapis, K.4    Groot, K.5
  • 18
    • 0016765178 scopus 로고
    • Pancreatic neoplasms in an animal model: Morphological, biological, and comparative studies
    • Pour P., Mohr U., Cardesa A., Althoff J., Kruger F.W. Pancreatic neoplasms in an animal model. morphological, biological, and comparative studies Cancer. 36:1975;379-389.
    • (1975) Cancer , vol.36 , pp. 379-389
    • Pour, P.1    Mohr, U.2    Cardesa, A.3    Althoff, J.4    Kruger, F.W.5
  • 19
    • 0026335802 scopus 로고
    • Inhibitory effect of bombesin/gastrin-releasing peptide antagonist RC-3095 and high dose of somatostatin analogue RC-160 on nitrosamine-induced pancreatic cancers in hamsters
    • Szepeshazi K., Schally A.V., Cai R.-Z., Radulovic S., Milovanovic S., Szoke B. Inhibitory effect of bombesin/gastrin-releasing peptide antagonist RC-3095 and high dose of somatostatin analogue RC-160 on nitrosamine-induced pancreatic cancers in hamsters. Cancer Res. 51:1991;5980-5986.
    • (1991) Cancer Res. , vol.51 , pp. 5980-5986
    • Szepeshazi, K.1    Schally, A.V.2    Cai, R.-Z.3    Radulovic, S.4    Milovanovic, S.5    Szoke, B.6
  • 20
    • 0020616606 scopus 로고
    • Establishment and characterization of human pancreatic adenocarcinoma cell line SW-1990 in tissue culture and the nude mice
    • Kyriazis A.P., McCombs III W.B., Sandberg A.A., Kyriazis A.A., Sloane N.H., Lepera R. Establishment and characterization of human pancreatic adenocarcinoma cell line SW-1990 in tissue culture and the nude mice. Cancer Res. 43:1983;4393-4401.
    • (1983) Cancer Res. , vol.43 , pp. 4393-4401
    • Kyriazis, A.P.1    McCombs W.B. III2    Sandberg, A.A.3    Kyriazis, A.A.4    Sloane, N.H.5    Lepera, R.6
  • 21
    • 0028845535 scopus 로고
    • Antagonists of bombesin/gastrin-releasing peptide inhibit growth of SW-1990 human pancreatic adenocarcinoma and production of cyclic AMP
    • Qin Y., Ertl T., Cai R.-Z., Horvàth J.E., Groot K., Schally A.V. Antagonists of bombesin/gastrin-releasing peptide inhibit growth of SW-1990 human pancreatic adenocarcinoma and production of cyclic AMP. Int. J. Cancer. 63:1995;257-262.
    • (1995) Int. J. Cancer , vol.63 , pp. 257-262
    • Qin, Y.1    Ertl, T.2    Cai, R.-Z.3    Horvàth, J.E.4    Groot, K.5    Schally, A.V.6
  • 22
    • 0025762632 scopus 로고
    • Decrease in the AgNOR number in Dunning R 3327 prostate cancer after treatment with LH-RH agonist and antagonist
    • Szepeshazi K., Korkut E., Schally A.V. Decrease in the AgNOR number in Dunning R 3327 prostate cancer after treatment with LH-RH agonist and antagonist. Am. J. Pathol. 138:1991;1273-1277.
    • (1991) Am. J. Pathol. , vol.138 , pp. 1273-1277
    • Szepeshazi, K.1    Korkut, E.2    Schally, A.V.3
  • 23
    • 0019061918 scopus 로고
    • Ligand: A versatile computerized approach for characterization of ligand-binding systems
    • Munson P.J., Rodbard D. Ligand. a versatile computerized approach for characterization of ligand-binding systems Anal. Biochem. 107:1980;220-239.
    • (1980) Anal. Biochem. , vol.107 , pp. 220-239
    • Munson, P.J.1    Rodbard, D.2
  • 24
    • 0032555287 scopus 로고    scopus 로고
    • Growth hormone-releasing hormone antagonist MZ-5-156 inhibits growth of DU-145 human androgen-independent prostate carcinoma in nude mice and suppresses the levels and mRNA expression of insulin-like growth factor II in tumors
    • Lamharzi N., Schally A.V., Koppan M., Groot K. Growth hormone-releasing hormone antagonist MZ-5-156 inhibits growth of DU-145 human androgen-independent prostate carcinoma in nude mice and suppresses the levels and mRNA expression of insulin-like growth factor II in tumors. Proc. Natl. Acad. Sci. USA. 95:1998;8864-8868.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8864-8868
    • Lamharzi, N.1    Schally, A.V.2    Koppan, M.3    Groot, K.4
  • 25
    • 0024356008 scopus 로고
    • Effects of the pH dependence of 3-(4,5-dimethylthiazol-2yl)-2, 5-diphenyltetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay
    • Plumb J.A., Milroy R., Kaye S.B. Effects of the pH dependence of 3-(4,5-dimethylthiazol-2yl)-2, 5-diphenyltetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay. Cancer Res. 49:1989;4435-4440.
    • (1989) Cancer Res. , vol.49 , pp. 4435-4440
    • Plumb, J.A.1    Milroy, R.2    Kaye, S.B.3
  • 26
    • 0023579858 scopus 로고
    • Human insulin-like growth factor I and II messenger RNA: Isolation of complementary DNA and analysis of expression
    • Rall L.B., Scott J., Bell G.I. Human insulin-like growth factor I and II messenger RNA. isolation of complementary DNA and analysis of expression Methods Enzymol. 146:1987;239-248.
    • (1987) Methods Enzymol. , vol.146 , pp. 239-248
    • Rall, L.B.1    Scott, J.2    Bell, G.I.3
  • 27
    • 0029777542 scopus 로고    scopus 로고
    • Expression of somatostatin receptor (SSTR) subtypes in pituitary adenomas: Quantitative analysis of SSTR2 mRNA by reverse transcription-polymerase chain reaction
    • Murabe H., Simatsu A., Ihara C.et al. Expression of somatostatin receptor (SSTR) subtypes in pituitary adenomas. quantitative analysis of SSTR2 mRNA by reverse transcription-polymerase chain reaction J. Neuroendocrinol. 8:1996;605-610.
    • (1996) J. Neuroendocrinol. , vol.8 , pp. 605-610
    • Murabe, H.1    Simatsu, A.2    Ihara, C.3
  • 28
    • 0030011399 scopus 로고    scopus 로고
    • Insulin-like growth factor I and insulin down-regulate growth hormone (GH) receptors in rat osteoblasts: Evidence for a peripheral feedback loop regulating GH action
    • Leung K.-C., Rajkovic I.A., Peters E., Markus I., Van Wyk J.J., Ho K.K.Y. Insulin-like growth factor I and insulin down-regulate growth hormone (GH) receptors in rat osteoblasts. evidence for a peripheral feedback loop regulating GH action Endocrinology. 137:1996;2694-2702.
    • (1996) Endocrinology , vol.137 , pp. 2694-2702
    • Leung, K.-C.1    Rajkovic, I.A.2    Peters, E.3    Markus, I.4    Van Wyk, J.J.5    Ho, K.K.Y.6
  • 29
    • 0025017059 scopus 로고
    • Insulin-like growth factor I and transforming growth factor as autocrine growth factors in human pancreatic cancer cell growth
    • Ohmura E., Okada M., Onoda N., Kamiya Y., Murakami H., Tsushima T. Insulin-like growth factor I and transforming growth factor as autocrine growth factors in human pancreatic cancer cell growth. Cancer Res. 50:1990;103-107.
    • (1990) Cancer Res. , vol.50 , pp. 103-107
    • Ohmura, E.1    Okada, M.2    Onoda, N.3    Kamiya, Y.4    Murakami, H.5    Tsushima, T.6
  • 30
    • 0029932442 scopus 로고    scopus 로고
    • Effect of human growth hormone on pancreatic carcinoma growth, protein, and cell cycle kinetics
    • Harrison L.E., Blumberg D., Berman R.et al. Effect of human growth hormone on pancreatic carcinoma growth, protein, and cell cycle kinetics. J. Surg. Res. 61:1996;317-322.
    • (1996) J. Surg. Res. , vol.61 , pp. 317-322
    • Harrison, L.E.1    Blumberg, D.2    Berman, R.3
  • 31
    • 0030728566 scopus 로고    scopus 로고
    • Serum levels of insulin-like growth factors (IGF-I and IGF-II) and their binding protein (IGFBP-3) are not elevated in pancreatic cancer
    • Evans J.D., Eggo M.C., Donovan I.A., Bramhall S.R., Neoptolemos J.P. Serum levels of insulin-like growth factors (IGF-I and IGF-II) and their binding protein (IGFBP-3) are not elevated in pancreatic cancer. Int. J. Pancreatol. 22:1997;95-100.
    • (1997) Int. J. Pancreatol. , vol.22 , pp. 95-100
    • Evans, J.D.1    Eggo, M.C.2    Donovan, I.A.3    Bramhall, S.R.4    Neoptolemos, J.P.5
  • 32
    • 0029948828 scopus 로고    scopus 로고
    • Involvement of IGF-II in human cancer
    • Toretsky J.A., Helman L.J. Involvement of IGF-II in human cancer. J. Endocrinol. 149:1996;367-372.
    • (1996) J. Endocrinol. , vol.149 , pp. 367-372
    • Toretsky, J.A.1    Helman, L.J.2
  • 33
    • 0031052582 scopus 로고    scopus 로고
    • Growth hormone as an amplifier of insulin-like growth factor-I action: Potential oestradiol accumulation
    • Xu Y.P., Chedrese P.J., Thacker P.A. Growth hormone as an amplifier of insulin-like growth factor-I action. potential oestradiol accumulation J. Endocrinol. 152:1997;201-209.
    • (1997) J. Endocrinol. , vol.152 , pp. 201-209
    • Xu, Y.P.1    Chedrese, P.J.2    Thacker, P.A.3
  • 34
    • 0028890744 scopus 로고
    • The insulin-like growth factor I receptor: A key to tumor growth
    • Baserga R. The insulin-like growth factor I receptor. a key to tumor growth Cancer Res. 55:1995;249-252.
    • (1995) Cancer Res. , vol.55 , pp. 249-252
    • Baserga, R.1
  • 35
    • 0029791877 scopus 로고    scopus 로고
    • A soluble insulin-like growth factor I receptor that induces apoptosis of tumor cells in vivo and inhibits tumorigenesis
    • D'Ambrosio C., Ferber A., Resnicoff M., Baserga R. A soluble insulin-like growth factor I receptor that induces apoptosis of tumor cells in vivo and inhibits tumorigenesis. Cancer Res. 56:1996;4013-4020.
    • (1996) Cancer Res. , vol.56 , pp. 4013-4020
    • D'Ambrosio, C.1    Ferber, A.2    Resnicoff, M.3    Baserga, R.4
  • 37
    • 0028957113 scopus 로고
    • Molecular and cellular aspects of the insulin-like growth factor I receptor
    • LeRoith D., Werner H., Beitner-Johnson D., Roberts C.T. Jr. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocrine Rev. 16:1995;143-163.
    • (1995) Endocrine Rev. , vol.16 , pp. 143-163
    • Leroith, D.1    Werner, H.2    Beitner-Johnson, D.3    Roberts C.T., Jr.4
  • 38
    • 0030277469 scopus 로고    scopus 로고
    • Editorial: Insulin-like growth factor (IGF)-binding proteins in serum do they have additional roles besides modulating the endocrine IGF actions?
    • Mohan S., Baylink D.J. Editorial. insulin-like growth factor (IGF)-binding proteins in serum do they have additional roles besides modulating the endocrine IGF actions? J. Clin. Endocrinol. Metab. 81:1996;3817-3820.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 3817-3820
    • Mohan, S.1    Baylink, D.J.2
  • 39
    • 0029586654 scopus 로고
    • IGFs in the feedback control of GH secretion: Hypothalamic and/or pituitary action?
    • Ceda G.P. IGFs in the feedback control of GH secretion. hypothalamic and/or pituitary action? J. Endocrinol. Invest. 18:1995;734-737.
    • (1995) J. Endocrinol. Invest. , vol.18 , pp. 734-737
    • Ceda, G.P.1
  • 40
    • 0029986038 scopus 로고    scopus 로고
    • A homologous radioimmunoassay for rat insulin-like growth factor-I (IGF-I). Implications for studies of human IGF-I physiology
    • Lee P.D.K., Baker B.K., Liu F., Kwan E.Y.W., Hintz R.L. A homologous radioimmunoassay for rat insulin-like growth factor-I (IGF-I). Implications for studies of human IGF-I physiology. J. Clin. Endocrinol. Metab. 81:1996;2002-2005.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 2002-2005
    • Lee, P.D.K.1    Baker, B.K.2    Liu, F.3    Kwan, E.Y.W.4    Hintz, R.L.5
  • 42
    • 0025157054 scopus 로고
    • Growth hormone receptor expression in the rat gastrointestinal tract
    • Lobie P.E., Breipohl W., Waters M.J. Growth hormone receptor expression in the rat gastrointestinal tract. Endocrinology. 126:1990;299-306.
    • (1990) Endocrinology , vol.126 , pp. 299-306
    • Lobie, P.E.1    Breipohl, W.2    Waters, M.J.3
  • 43
    • 0030472413 scopus 로고    scopus 로고
    • Effects of acute and chronic administration of a new potent antagonist of growth hormone-releasing hormone in rats: Mechanisms of action
    • Kovacs M., Zarandi M., Halmos G., Groot K., Schally A.V. Effects of acute and chronic administration of a new potent antagonist of growth hormone-releasing hormone in rats. mechanisms of action Endocrinology. 137:1996;5364-5369.
    • (1996) Endocrinology , vol.137 , pp. 5364-5369
    • Kovacs, M.1    Zarandi, M.2    Halmos, G.3    Groot, K.4    Schally, A.V.5
  • 44
    • 0032981091 scopus 로고    scopus 로고
    • Inhibition of growth, production of insulin-like growth factor-II (IGF-II), and expression of IGF-II mRNA of human cancer cell lines by antagonistic analogs of growth hormone-releasing hormone in vitro
    • Csernus V.J., Schally A.V., Kiaris H., Armatis P. Inhibition of growth, production of insulin-like growth factor-II (IGF-II), and expression of IGF-II mRNA of human cancer cell lines by antagonistic analogs of growth hormone-releasing hormone in vitro. Proc. Natl. Acad. Sci. USA. 96:1999;3098-3103.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3098-3103
    • Csernus, V.J.1    Schally, A.V.2    Kiaris, H.3    Armatis, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.