Immunohistochemical detection of GHRH and its receptor splice variant 1 in primary human breast cancers

European Journal of Endocrinology

Volumn 151, Issue 3, 2004, Pages 391-396

  Chatzistamou, Ioulia ^a   Schally, Andrew V ^c   Kiaris, Hippokratis ^b   Politi, Ekaterini ^a   Varga, Jozsef ^c   Kanellis, George ^a   Kalofoutis, Anastasios ^b   Pafiti, Agatha ^a   Koutselini, Helen ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE RELEASING FACTOR RECEPTOR;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER GRADING; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MASTECTOMY; PRIORITY JOURNAL; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ALTERNATIVE SPLICING; AUTOCRINE COMMUNICATION; BREAST NEOPLASMS; FEMALE; GROWTH HORMONE-RELEASING HORMONE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; RECEPTORS, NEUROPEPTIDE; RECEPTORS, PITUITARY HORMONE-REGULATING HORMONE;

EID: 4744362859     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1510391     Document Type: Article

References (25)

1. Schally AV & Comaru-Schally AM. Agonistic analogs of growth hormone-releasing hormone (GH-RH): endocrine and growth studies. In Growth Hormone Secretagogues in Clinical Practice, pp 14-31. Eds BB Bercu & RF Walker. New York: Marcel Dekker, 1998.
2. Schally AV, Steelman S & Bowers CY. Effect of hypothalamic extracts on the release of growth hormone in vitro. Proceedings of the Society for Experimental Biology and Medicine 1965 119 208-212.
3. Krulich L, Dhariwal APS & McCann SM. Stimulatory and inhibitory effects of purified hypothalamic extracts on growth hormone release from rat pituitary in vitro. Endocrinology 1968 83 783-790.
4. Schally AV & Varga JL. Antagonistic analogs of growth hormone-releasing hormone: new potential antitumor agents. Trends in Endocrinology and Metabolism 1999 10 383-391.
5. Kiaris H, Koutsilieris M, Kalofoutis A & Schally AV. Growth hormone-releasing hormone and extra-pituitary tumorigenesis: therapeutic and diagnostic applications of growth hormone-releasing hormone antagonists. Expert Opinion in Investigational Drugs 2003 12 1385-1394.
6. Kiaris H, Schally AV, Varga JL, Groot K & Armatis P. Growth hormone-releasing hormone: an autocrine growth factor for small cell lung carcinoma. PNAS 1999 96 3098-3103.
7. Busto R, Schally AV, Varga JL, Garcia-Fernandez MO, Groot K, Armatis P & Szepeshazi K. The expression of growth hormone-releasing hormone (GHRH) and splice variants of its receptor in human gastroenteropancreatic carcinomas. PNAS 2002 99 11866-11871.
8. Busto R, Schally A, Braczkowski R, Plonowski A, Krupa M, Groot K, Armatis P & Varga J. Expression of mRNA for growth hormone-releasing hormone and splice variants of GHRH receptors in human malignant bone tumors. Regulatory Peptides 2002 108 47-53.
9. Chatzistamou I, Schally AV, Varga JL, Groot K, Busto R, Armatis P & Halmos G. Inhibition of growth and metastases of MDA-MB-435 human estrogen-independent breast cancers by an antagonist of growth hormone-releasing hormone. Anticancer Drugs 2001 12 761-768.
10. Zeitler P & Siriwardana G. Antagonism of endogenous growth hormone-releasing hormone (GHRH) leads to reduced proliferation and apoptosis in MDA231 breast cancer cells. Endocrine 2002 18 85-90.
11. Chatzistamou I, Schally AV, Varga JL, Groot K, Armatis P, Busto R & Halmos G. Antagonists of growth hormone-releasing hormone and somatostatin analog RC-160 inhibit the growth of the OV-1063 human epithelial ovarian cancer cell line xenografted into nude mice. Journal of Clinical Endocrinology and Metabolism 2001 86 2144-2152.
12. Csernus EJ, Schally AV, Kiaris H & Armatis P. Inhibition of growth, production of insulin-like growth factor-II (IGF-II), and expression of IGF-II mRNA of human cancer cell lines by antagonistic analogs of growth hormone-releasing hormone in vitro. PNAS 1999 96 3098- 3103.
13. Szepeshazi K, Schally AV, Groot K, Armatis P, Hebert F & Halmos G. Antagonists of growth hormone-releasing hormone (GH-RH) inhibit in vivo proliferation of experimental pancreatic cancers and decrease IGF-II levels in tumors. European Journal of Cancer 2000 36 128-136.
14. Szepeshazi K, Schally AV, Groot K, Armatis P, Halmos G, Hebert F. Szende B, Varga JL & Zarandi M. Antagonists of growth hormone-releasing hormone (GH-RH) inhibit IGF-II production and growth of HT-29 human colon cancers. British Journal of Cancer 2000 82 1724-1731.
15. Braczkowski R, Schally AV, Plonowski A, Varga JL, Groot K, Krupa M & Armatis P. Inhibition of proliferation in human MNNG/HOS osteosarcoma and SK-ES-1 Ewing sarcoma cell lines in vitro and in vivo by antagonists of growth hormone-releasing hormone. Cancer 2002 95 1735-1745.
16. Halmos G, Schally AV, Varga JL, Plonowski A, Rekasi Z & Czompoly T. Human renal cell carcinoma expresses distinct binding sites for growth hormone-releasing hormone. PNAS 2000 97 10555-10560.
17. Rekasi Z, Czompoly T, Schally AV & Halmos G. Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers. PNAS 2000 97 10561-10566.
18. Kiaris H, Schally AV, Busto R, Halmos G, Artavanis-Tsakonas S & Varga JL. Expression of splice variant for GHRH receptor SV1 mediates mitogenic effects in 3T3 fibroblasts. PNAS 2002 99 196-200.
19. Kiaris H, Chatzistamou I, Schally AV, Halmos G, Varga JL, Koutselini H & Kalofoutis A. Ligand-dependent and -independent effects of splice variant 1 of growth hormone-releasing hormone receptor. PNAS 2003 100 9512-9517.
20. Kahan Z, Varga JL, Schally AV, Rekasi Z, Armatis P, Chatzistamou I, Czompoly T & Halmos G. Antagonists of growth hormone-releasing hormone arrest the growth of MDA-MB-468 estrogen-independent human breast cancers in nude mice. Breast Cancer Research and Treatment 2000 60 71-79.
21. Chatzistamou I, Schally AV, Varga JL, Groot K, Busto R, Armatis P & Halmos G. Inhibition of growth and metastases of MDA-MB-435 human estrogen-independent breast cancers by an antagonist of growth hormone-releasing hormone. Anticancer Drugs 2001 12 761-768.
22. Kahan Z, Arencibia JM, Czernus VJ, Groot K, Kineman RD, Robinson WR & Schally AV. Expression of growth hormone-releasing hormone (GH-RH) messenger ribonucleic acid and the presence of biologically active GH-RH in human breast, endometrial and ovarian cancers. Journal of Clinical Endocrinology and Metabolism 1999 84 582-589.
23. Groot K. Csernus VJ, Pinski J, Zsigo J, Rekasi Z, Zarandi M & Schally AV. Development of a radioimmunoassay for some agonists of growth hormone-releasing hormone. International Journal of Peptide and Protein Research 1993 41 162-168.
24. Kiaris H, Schally AV & Armatis P. Direct action of growth hormone-releasing hormone agonist JI-38 on normal human diploid fibroblasts: evidence from studies on cell proliferation and c-myc oncogene expression. Regulatory Peptides 2001 96 119-124.
25. Chatzistamou I, Schally AV, Pafiti A, Kiaris H & Koutselini H. Expression of growth hormone-releasing hormone in human primary endometrial carcinomas. European Journal of Endocrinology 2002 147 381-386.