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Volumn 877, Issue 22, 2009, Pages 2074-2080
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Liquid chromatographic tandem mass spectrometric assay for quantification of 97/78 and its metabolite 97/63: A promising trioxane antimalarial in monkey plasma
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Author keywords
Antimalarial; LC MS MS; Monkey plasma; Trioxane; Validation
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Indexed keywords
ANTIMALARIAL;
LC-MS/MS;
MONKEY PLASMA;
TRIOXANE;
VALIDATION;
ACETONITRILE;
AMMONIUM COMPOUNDS;
BIOMOLECULES;
HIGH PRESSURE LIQUID CHROMATOGRAPHY;
MASS SPECTROMETERS;
MASS SPECTROMETRY;
METABOLISM;
METABOLITES;
POSITIVE IONS;
STANDARDIZATION;
PLASMAS;
97 63;
97 78;
ACETONITRILE;
AMMONIUM ACETATE;
ARTEETHER;
ARTEMISININ DERIVATIVE;
DRUG METABOLITE;
UNCLASSIFIED DRUG;
ACCURACY;
ANIMAL EXPERIMENT;
AREA UNDER THE CURVE;
ARTICLE;
CALIBRATION;
CONCENTRATION RESPONSE;
DRUG BLOOD LEVEL;
DRUG HALF LIFE;
DRUG ISOLATION;
DRUG STABILITY;
ELUTION;
FLOW RATE;
FREEZE THAWING;
IN VIVO STUDY;
LIQUID CHROMATOGRAPHY;
MALE;
MAXIMUM PLASMA CONCENTRATION;
NONHUMAN;
PLASMA CONCENTRATION-TIME CURVE;
PRIORITY JOURNAL;
QUANTITATIVE ANALYSIS;
RHESUS MONKEY;
TANDEM MASS SPECTROMETRY;
TIME TO MAXIMUM PLASMA CONCENTRATION;
VALIDATION PROCESS;
ANIMALS;
ANTIMALARIALS;
ARTEMISININS;
CHROMATOGRAPHY, LIQUID;
DISEASE MODELS, ANIMAL;
HUMANS;
MACACA MULATTA;
MALARIA;
MALE;
TANDEM MASS SPECTROMETRY;
MACACA MULATTA;
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EID: 67649210309
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2009.05.044 Document Type: Article |
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Times cited : (14)
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References (16)
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