Assessment of the extrudability of three different mixtures of saturated polyglycolysed glycerides by determination of the "specific work of extrusion" and by capillary rheometry

Pharmaceutical Development and Technology

Volumn 6, Issue 1, 2001, Pages 117-128

  Pinto, J F ^a   Silverio N R ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

"Specific work of extrusion"; Extrusion; Glyceride; Polyethyleneglycol; Rheometry

Indexed keywords

ACYLGLYCEROL; MACROGOL;

ARTICLE; BIOAVAILABILITY; DRUG FORMULATION; ELASTICITY; FORCE; GLYCOSYLATION; PRESSURE; PRIORITY JOURNAL; SHEAR STRESS; VISCOELASTICITY;

DRUG CARRIERS; ELASTICITY; GLYCERIDES; GLYCOSYLATION; RHEOLOGY; SOLUBILITY; TEMPERATURE;

EID: 0035127104     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100000045     Document Type: Article

References (20)

1. Sustained Release of Naltrexone from Glyceride Implants
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3. Influence of Water-Soluble Polymers on the Dissolution of Nifedipine Solid Dispersions with Combined Carriers
4. Solidification Studies of Polyethyleneglycols, Gelucire 44/14 or Their Dispersions with Triamterene or Temazepam
5. Effect of Vehicle Amphiphilicity on the Dissolution and Bioavailability of a Poorly Water-Soluble Drug from Solid Dispersions
6. Properties of Sustained-Release Tablets Prepared by Hot-Melt Extrusion
7. Extrusion-Spheronization Manufacture of Gelucire Matrix Beads
8. Various Ways of Modulating the Release of Diltiazem Hydrochloride from Hot-Melt Extruded Sustained Release Pellets Prepared Using Polymeric Materials
9. Compaction Studies on Beads: Compression and Consolidation Parameters
10. Influence of Disintegrant Type and Proportion on the Properties of Tablets Produced from Mixtures of Pellets
11. Capacity of Lipophilic Auxiliary Substances to Give Spheres by Extrusion-Spheronization
12. Process and Formulation Variables in the Preparation of Wax Microparticles by Melt Dispersion Technique. I. Oil-in-Water Technique for Water-Insoluble Drugs
13. Effect of Formulation on the Rheology of Theophylline Compound Suspensions in Gelucires
14. Lipid-Based Delivery Systems for Improving the Bioavailability and Lymphatic Transport of a Poorly Water-Soluble LTB4 Inhibitor
15. An Evaluation of the Mechanisms of Drug Release from Glyceride Bases
16. Modified Release Matrix Prepared by Compaction of Spheres Containing a Waxy Material
17. The Application of Capillary Rheometry to the Extrusion of Wet Powder Masses
18. Rheological Behavior of Saturated Polyglycolysed Glycerides
19. End Correction in the Capillary Flow of Polyethylene
20. Rate- or Stress-Controlled Rheometry