Effect of FK506 and cyclosporine A on the expression of BDNF, tyrosine kinase B and p75 neurotrophin receptors in astrocytes exposed to simulated ischemia in vitro

Cell Biology International

Volumn 33, Issue 7, 2009, Pages 739-748

  Gabryel, Bozena ^a   Bernacki, Jacek ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

Astrocytes; BDNF; Cyclosporine A; FK506; Ischemia; p CREB; p75NTR; TrkB

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOSPORIN A; GLUCOSE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROTROPHIN RECEPTOR P75; OXYGEN; PROTEIN KINASE B; TACROLIMUS;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN CORTEX; CELL CULTURE; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VITRO STUDY; ISCHEMIA; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ASTROCYTES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CREB-BINDING PROTEIN; CYCLOSPORINE; IMMUNOSUPPRESSIVE AGENTS; ISCHEMIA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RECEPTOR, NERVE GROWTH FACTOR; RECEPTOR, TRKB; RNA, MESSENGER; TACROLIMUS;

RATTUS;

EID: 67549106606     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2009.04.006     Document Type: Article

References (44)

1. Ballarin M., Ernfors P., Lindefors N., and Persson H. Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain. Exp Neurol 114 (1991) 35-43
2. Banafshe H.R., Ghazi-Khansari M., Ejtemaei Mehr S., and Dehpour A.R. Cyclosporine A attenuates the adenylyl cyclase superactivation induced by chronic cannabinoid treatment. Eur J Pharmacol 557 (2007) 20-22
3. Benedetti M., Levi A., and Chao M.V. Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness. Proc Natl Acad Sci U S A 90 (1993) 7859-7863
4. Bito H., Deisseroth K., and Tsien R.W. CREB phosphorylation and dephosphorylation: a Ca(2+) and stimulus duration-dependent switch for hippocampal gene expression. Cell 87 (1996) 1203-1204
5. Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye-binding. Anal Biochem 72 (1976) 248-251
6. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162 (1987) 156-159
7. Condorelli D.F., Dell'Albani P., Mudo G., Timmusk T., and Belluardo N. Expression of neurotrophins and their receptors in primary astroglial cultures: induction by cyclic AMP-elevating agents. J Neurochem 63 (1994) 509-516
8. Deogracias R., Espliguero G., Iglesias T., and Rodríguez-Peña A. Expression of the neurotrophin receptor trkB is regulated by the cAMP/CREB pathway in neurons. Mol Cell Neurosci 26 (2004) 470-480
9. Dignam J.D., Lebovitz R.M., and Roeder R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11 (1983) 1474-1489
10. Domanska-Janik K., Buzanska L., Dluzniewska J., Kozlowska H., Sarnowska A., and Zablocka B. Neuroprotection by cyclosporin A following transient brain ischemia correlates with the inhibition of the early efflux of cytochrome C to cytoplasm. Brain Res Mol Brain Res 121 (2004) 50-59
11. Ferrer I., Ballabriga J., Martí E., Pérez E., Alberch J., and Arenas E. BDNF up-regulates TrkB protein and prevents the death of CA1 neurons following transient forebrain ischemia. Brain Pathol 8 (1998) 253-261
12. Gabryel B., Labuzek K., Malecki A., and Herman Z.S. Immunophilin ligands decrease release of pro-inflammatory cytokines IL-1beta, TNF-alpha and IL-2 in rat astrocyte cultures exposed to simulated ischemia in vitro. Pol J Pharmacol 56 (2004) 129-136
13. Gabryel B., Pudelko A., Adamczyk J., Fischer I., and Malecki A. Calcineurin and Erk1/2- signaling pathways are involved in the antiapoptotic effect of cyclosporin A on astrocytes exposed to simulated ischemia in vitro. Naunyn Schmiedebergs Arch Pharmacol 374 (2006) 127-139
14. Gabryel B., Chalimoniuk M., Stolecka A., Waniek K., Langfort J., and Malecki A. Inhibition of arachidonic acid release by cytosolic phospholipase A2 is involved in the antiapoptotic effect of FK506 and cyclosporin a on astrocytes exposed to simulated ischemia in vitro. J Pharmacol Sci 102 (2006) 77-87
15. Han B.H., and Holtzman D.M. BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway. J Neurosci 20 (2000) 5775-5781
16. Hertz L., Juurlink B.H.J., and Szuchet S. Cell cultures. In: Lajtha A. (Ed). Handbook of neurochemistry (1985), Plenum Press, New York 603-661
17. Impey S., Obrietan K., Wong S.T., Poser S., Yano S., Wayman G., et al. Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation. Neuron 21 (1998) 869-883
18. Jiang Z., Zhang Y., Chen X., Lam P.Y., Yang H., Xu Q., et al. Activation of Erk1/2 and Akt in astrocytes under ischemia. Biochem Biophys Res Commun 294 (2002) 726-733
19. Jiang X., Tian F., Mearow K., Okagaki P., Lipsky R.H., and Marini A.M. The excitoprotective effect of N-methyl-D-aspartate receptors is mediated by a brain-derived neurotrophic factor autocrine loop in cultured hippocampal neurons. J Neurochem 94 (2005) 713-722
20. Kaplan D.R., and Miller F.D. Signal transduction by the neurotrophin receptors. Curr Opin Cell Biol 9 (1997) 213-221
21. Kim D.W., Lee J.H., Park S.K., Yang W.M., Jeon G.S., Lee Y.H., et al. Astrocytic expressions of phosphorylated Akt, GSK3beta and CREB following an excitotoxic lesion in the mouse hippocampus. Neurochem Res 32 (2007) 1460-1468
22. Kingsbury T.J., and Krueger B.K. Ca2+, CREB and krüppel: a novel KLF7-binding element conserved in mouse and human TRKB promoters is required for CREB-dependent transcription. Mol Cell Neurosci 35 (2007) 447-455
23. Koyama Y., Tsujikawa K., Matsuda T., and Baba A. Endothelin increases expression of exon III- and exon IV-containing brain-derived neurotrophic factor transcripts in cultured astrocytes and rat brain. J Neurosci Res 80 (2005) 809-816
24. Lee R.K., Araki W., and Wurtman R.J. Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation. Proc Natl Acad Sci U S A 94 (1997) 5422-5426
25. Miyata K., Omori N., Uchino H., Yamaguchi T., Isshiki A., and Shibasaki F. Involvement of the brain-derived neurotrophic factor/TrkB pathway in neuroprotective effect of cyclosporin A in forebrain ischemia. Neuroscience 105 (2001) 571-578
26. Mosman T. Rapid, colorimetric assay for cellular growth and survival. Application to proliferation and cytotoxicity assays. J Immunol Methods 65 (1983) 55-63
27. Mowla S.J., Farhadi H.F., Pareek S., Atwal J.K., Morris S.J., Seidah N.G., et al. Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor. J Biol Chem 276 (2001) 12660-12666
28. Nagappan G., and Lu B. Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications. Trends Neurosci 28 (2005) 464-471
29. Oderfeld-Nowak B., Orzylowska-Sliwinska O., Soltys Z., Zaremba M., Januszewski S., Janeczko K., et al. Concomitant up-regulation of astroglial high and low affinity nerve growth factor receptors in the CA1 hippocampal area following global transient cerebral ischemia in rat. Neuroscience 120 (2003) 31-40
30. Patapoutian A., and Reichardt L.F. Trk receptors: mediators of neurotrophin action. Curr Opin Neurobiol 11 (2001) 272-280
31. Phillis J.W., Diaz F.G., O'Regan M.H., and Pilitsis J.G. Effects of immunosuppressants, calcineurin inhibition, and blockade of endoplasmic reticulum calcium channels on free fatty acid efflux from the ischemic/reperfused rat cerebral cortex. Brain Res 957 (2002) 12-24
32. Rao J.S., Ertley R.N., Lee H.J., DeMar Jr. J.C., Arnold J.T., Rapoport S.I., et al. n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism. Mol Psychiatry 12 (2007) 36-46
33. Schwaninger M., Blume R., Kruger M., Lux G., Oetjen E., and Knepel W. Involvement of the Ca(2+)-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements. J Biol Chem 270 (1995) 8860-8866
34. Simmons M.L., and Murphy S. Induction of nitric oxide synthase in glial cells. J Neurochem 59 (1992) 897-905
35. Sinigaglia-Coimbra R., Cavalheiro E.A., and Coimbra C. Protective effect of systemic treatment with cyclosporine A after global ischemia in rats. J Neurol Sci 203 (2002) 273-276
36. Szydlowska K., Zawadzka M., and Kaminska B. Neuroprotectant FK506 inhibits glutamate- induced apoptosis of astrocytes in vitro and in vivo. J Neurochem 99 (2006) 965-975
37. Tan J., and Shepherd R.K. Aminoglycoside-induced degeneration of adult spiral ganglion neurons involves differential modulation of tyrosine kinase B and p75 neurotrophin receptor signaling. Am J Pathol 169 (2006) 528-543
38. Teng H.K., Teng K.K., Lee R., Wright S., Tevar S., Almeida R.D., et al. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci 25 (2005) 5455-5463
39. Tokumine J., Kakinohana O., Cizkova D., Smith D.W., and Marsala M. Changes in spinal GDNF, BDNF, and NT-3 expression after transient spinal cord ischemia in the rat. J Neurosci Res 74 (2003) 552-561
40. Uchino H., Minamikawa-Tachino R., Kristian T., Perkins G., Narazaki M., Siesjo B.K., et al. Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhibit calcineurin and the mitochondrial permeability transition. Neurobiol Dis 10 (2002) 219-233
41. Yamaguchi T., Miyata K., Shibasaki F., Isshiki A., and Uchino H. Effect of cyclosporin a on immediate early gene in rat global ischemia and its neuroprotection. J Pharmacol Sci 100 (2006) 73-81
42. Zawadzka M., and Kaminska B. Immunosuppressant FK506 affects multiple signaling pathways and modulates gene expression in astrocytes. Mol Cell Neurosci 22 (2003) 202-209
43. Zhao L., and Brinton R.D. Vasopressin-induced cytoplasmic and nuclear calcium signaling in embryonic cortical astrocytes: dynamics of calcium and calcium-dependent kinase translocation. J Neurosci 23 (2003) 4228-4239
44. Zhou J., Pliego-Rivero B., Bradford H.F., and Stern G.M. The BDNF content of postnatal and adult rat brain: the effects of 6-hydroxydopamine lesions in adult brain. Brain Res Dev Brain Res 97 (1996) 297-303