There is no transmural heterogeneity in an index of action potential duration in the canine left ventricle

Heart Rhythm

Volumn 6, Issue 7, 2009, Pages 1028-1034

  Voss, Frederik ^a   Opthof, Tobias ^b,c   Marker, Jens ^a   Bauer, Alexander ^a   Katus, Hugo A ^a   Becker, Ruediger ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Arrhythmia; Cardiac heterogeneity; M cell; Repolarization; Torsade de pointes; Transmural heterogeneity

Indexed keywords

ANIMAL EXPERIMENT; ARTERY PERFUSION; ARTICLE; CONTROLLED STUDY; DOG; ELECTRODE; HEART ELECTROPHYSIOLOGY; HEART LEFT VENTRICLE; HEART MUSCLE REFRACTORY PERIOD; HEART REPOLARIZATION; HEART VENTRICLE WALL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL;

ACTION POTENTIALS; ANIMALS; DOGS; ELECTRODES, IMPLANTED; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; FEMALE; HEART VENTRICLES; MALE; TIME FACTORS; VENTRICULAR FUNCTION;

EID: 67549096439     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2009.03.028     Document Type: Article

References (29)

1. Sicouri S., and Antzelevitch C. A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle: The M cell. Circ Res 68 (1991) 1729-1741
2. Antzelevitch C., Shimizu W., Yan G.X., et al. The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart. J Cardiovasc Electrophysiol 10 (1999) 1124-1152
3. Ks contributes to the longer action potential of the M cell. Circ Res 76 (1995) 351-365
4. Zygmunt A.C., Eddlestone G.T., Thomas G.P., et al. Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle. Am J Physiol 281 (2001) H689-H697
5. Bauer A., Becker R., Freigang K.D., et al. Rate- and site-dependent effects of propafenone, dofetilide, and the new Iks-blocking agent chromanol 293b on individual muscle layers of the intact canine heart. Circulation 100 (1999) 2184-2190
6. Voss F., Schreiner K.D., Senges J.C., et al. Refractory patterns and susceptibility to drug-induced polymorphic ventricular tachycardias in dogs with chronic atrioventricular block: relation to the type of anesthesia. J Cardiovasc Pharmacol 40 (2002) 651-659
7. Anyukhovsky E.P., Sosunov E.A., and Rosen M.R. Regional differences in electrophysiological properties of epicardium, midmyocardium, and endocardium: in vitro and in vivo correlations. Circulation 94 (1996) 1981-1988
8. Anyukhovsky E.P., Sosnunov E.A., Feinmark S.J., et al. Effects of quinidine on repolarization in canine epicardium, midmyocardium, and endocardium: II. In vivo study. Circulation 96 (1997) 4019-4026
9. Anyukhovsky E.P., Sosunov E.A., Gainullin R.Z., et al. The controversial M cell. J Cardiovasc Electrophysiol 10 (1999) 244-260
10. Janse M.J., Sosunov E.A., Coronel R., et al. Repolarization gradients in the canine left ventricle before and after induction of short-term cardiac memory. Circulation 112 (2005) 1711-1718
11. El-Sherif N., Caref E.B., Yin H., and Restivo M. The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome: tridimensional mapping of activation and recovery patterns. Circ Res 79 (1996) 474-492
12. Weissenburger J., Nesterenko V.V., and Antzelevitch C. Transmural heterogeneity of ventricular repolarization under baseline and long QT conditions in the canine heart in vivo: torsade de pointes develops with halothane but not pentobarbital anesthesia. J Cardiovasc Electrophysiol 11 (2000) 290-304
13. Drouin E., Charpentier F., Gauthier C., et al. Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: evidence for presence of M cells. J Am Coll Cardiol 26 (1995) 185-192
14. Conrath C.E., Wilders R., Coronel R., et al. Intercellular coupling through gap junctions masks M cells in the human heart. Cardiovasc Res 62 (2004) 407-414
15. Taggart P., Sutton P.M.I., Opthof T., et al. Transmural repolarisation in the left ventricle in humans during normoxia and ischemia. Cardiovasc Res 50 (2001) 454-462
16. Coronel R., De Bakker J.M.T., Wilms-Schopman F.J., et al. Monophasic action potentials and activation-recovery-intervals as measures of ventricular action potential duration. Experimental evidence to resolve some controversies. Heart Rhythm 3 (2006) 1043-1050
17. p-e interval does not reflect transmural dispersion. Heart Rhythm 4 (2007) 341-348
18. Opthof T., Coronel R., and Janse M.J. Repolarization gradients in the intact heart. Circ Arrhythmia Electrophysiol 2 (2009) 89-96
19. Conrath C.E., and Opthof T. Ventricular repolarization. An overview of (patho)physiology, sympathetic effects, and genetic aspects. Prog Biophys Mol Biol 92 (2006) 269-307
20. Morita S.T., Zipes D.P., Morita H., et al. Analysis of action potentials in the canine ventricular septum: no phenotypic expression of M cells. Cardiovasc Res 74 (2007) 96-103
21. Ueda N., Zipes D.P., and Wu J. Functional and transmural modulation of M cell behaviour in canine ventricular wall. Am J Physiol Heart Circ Physiol 287 (2004) H2569-H2575
22. Opthof T., Coronel R., Rosen M.R., et al. A wedge is not a heart. Heart Rhythm 4 (2007) 1116-1119
23. end provide an index of transmural dispersion of repolarization?. Heart Rhythm 4 (2007) 1114-1116
24. Van Dam R.T.H., and Durrer D. Experimental study of the intramural distribution of the excitability cycle and on the form of the epicardial T wave in the dog heart in situ. Am Heart J 61 (1961) 537-542
25. Akar F.G., Yan G.X., Antzelevitch C., et al. Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome. Circulation 105 (2002) 1247-1253
26. Voss F., Schoels W., Lue J., et al. Regional differences in the dynamics of refractoriness in intact and hypertrophied in situ canine hearts. Basic Res Cardiol 100 (2005) 433-438
27. Yan G.X., Shimizu W., and Antzelevitch C. Characteristics and distribution of M cells in arterially-perfused canine left ventricular wedge preparations. Circulation 98 (1998) 1924-1927
28. Antzelevitch C., Sun Z.Q., Zhang Z.Q., et al. Cellular and ionic mechanisms underlying erythromycin-induced long QT intervals and torsade de pointes. J Am Coll Cardiol 28 (1996) 1836-1848
29. Solberg L.E., Singer D.H., Ten Eick R.E., et al. Glass microelectrode studies on intramural papillary muscle cells. Circ Res 34 (1974) 783-796