Polymeric matrix system for prolonged delivery of tramadol hydrochloride, part I: Physicochemical evaluation

AAPS PharmSciTech

Volumn 10, Issue 1, 2009, Pages 7-20

  Ammar, Hussein O ^a   Ghorab, M ^b   El Nahhas, S A ^a   Kamel, R ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

Matrix system; Pain; Polymers; Tramadol hydrochloride

Indexed keywords

CHITOSAN; EUDRAGIT; TRAMADOL; DRUG CARRIER; EUDRAGIT NE 30-D; METHACRYLIC ACID DERIVATIVE; NARCOTIC ANALGESIC AGENT; PLASTICIZER; POLYMER; WATER;

ANALGESIC ACTIVITY; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG SAFETY; DRUG UPTAKE; FOURIER TRANSFORM MASS SPECTROMETRY; HYDROPHOBICITY; MATRIX TABLET; MOISTURE; NONHUMAN; PH; PHYSICAL CHEMISTRY; POROSITY; SURFACE PROPERTY; TRANSDERMAL PATCH; ANIMAL; CHEMICAL MODEL; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG DOSAGE FORM; INFRARED SPECTROSCOPY; INTRADERMAL DRUG ADMINISTRATION; KINETICS; METABOLISM; METHODOLOGY; PERMEABILITY; PHARMACEUTICS; RAT; SKIN; SKIN ABSORPTION; SOLUBILITY;

ADMINISTRATION, CUTANEOUS; ANALGESICS, OPIOID; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DELAYED-ACTION PREPARATIONS; DOSAGE FORMS; DRUG CARRIERS; DRUG COMPOUNDING; HYDROGEN-ION CONCENTRATION; KINETICS; METHACRYLATES; MODELS, CHEMICAL; PERMEABILITY; PLASTICIZERS; POLYMERS; RATS; SKIN; SKIN ABSORPTION; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TECHNOLOGY, PHARMACEUTICAL; TRAMADOL; WATER;

EID: 67549087101     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-008-9167-0     Document Type: Article

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