Synthesis, characterization and in vivo activity of salmon calcitonin coconjugated with lipid and polyethylene glycol

Journal of Pharmaceutical Sciences

Volumn 98, Issue 4, 2009, Pages 1438-1451

  Cheng, Weiqianc ^a,c   Lim, Lee Yong ^b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Aggregation; Conformation; Hypocalcemic activity; Lipidization; Pegylation; Salmon calcitonin; Stability

Indexed keywords

CYSTINE; LIPID; LYSINE; MACROGOL; PALMITIC ACID DERIVATIVE; SALCATONIN; SUCCINIMIDE;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL BOND; CHEMICAL REACTION; CIRCULAR DICHROISM; CONFORMATION; CONJUGATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STABILITY; ENZYME DEGRADATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOCALCEMIA; INTESTINE FLUID; LIGHT SCATTERING; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PURIFICATION; RAT; SYNTHESIS;

EID: 67449158708     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21524     Document Type: Article

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