Behavioral and ultrastructural changes of intrathecal administered ropivacaine in spinal cord of rats

Journal of Central South University (Medical Sciences)

Volumn 34, Issue 4, 2009, Pages 362-368

  Zhang, Zhong ^a   Hu, Yajiao ^b   Zhao, Yuan ^a   Chen, Chan ^a   Guo, Julian ^a   Sun, Zhihua ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b Central South University   (China)

Author keywords

Ropivacaine; Spinal cord; Toxicity; Ultrastructure

Indexed keywords

AMIDE; LOCAL ANESTHETIC AGENT; ROPIVACAINE;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; DOSE RESPONSE; DRUG EFFECT; ELECTRON MICROSCOPY; INTRASPINAL DRUG ADMINISTRATION; MALE; RANDOMIZATION; RAT; SPINAL CORD; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

AMIDES; ANESTHETICS, LOCAL; ANIMALS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, SPINAL; MALE; MICROSCOPY, ELECTRON; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 67449136402     PISSN: 16727347     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Pollock J E. Neurotoxicity of intrathecal local anaesthetics and transient neurological symptoms [J]. Best Pract Res Clin Anaesthesiol , 2003 , 17 ( 3 ) : 471-484.
2. Yaksh T L , Rudy T A. Chronic catheterization of the spinal subarachnoid space [J]. Physiol Behav , 1976 , 17(6) : 1031-1036.
3. Sakura S , Kirihara Y , Muguruma T , et al. The comparative neurotoxicity of intrathecal lidocaine and bupivacaine in rats [J] . Anesth Analg, 2005 , 101 (2) : 541-547.
4. Malinovsky J M , Charles F , Baudrimont M , et al. Intrathe- cal ropivacaine in rabbits : pharmacodynamic and neurotoxico- logic study [J]. Anesthesiology , 2002 , 97(2): 429- 435.
5. Radwan I A , Saito S , Goto F. The neurotoxicity of local an- esthetics on growing neurons : a comparative study of lido- caine , bupivacaine , mepivacaine, and ropivacaine [J]. Anesth Analg, 2002 , 94(2) : 319-324.
6. SUN Zhihua , GUO Qulian , ZOU Wangyuan. Effect of con- tinuous spinal anesthesia with ropivacaine on the ultrastructure of spinal cord and nerve roots in rats [J]. Chin J Anesthesiol, 2005, 5(4) : 83-287.
7. SUN Zhihua , GUO Qulian , ZOU Wangyuan. Behaviorial ob- servation of ropivacaine in continuous spinal anesthesia and Ca content of spinal cord in rats [J]. J Cent South Univ. Med Sci , 2005 , 30( 1 ) : 88-91.
8. Rose F X , Estebe J P, Ratajczak M , et al. Epidural , in- trathecal pharmacokinetics , and intrathecal bioavailability of ropivacaine [J]. Anesth Analg , 2007 , 105 ( 3 ) : 859- 867.
9. Takenami T , Yagishita S , Murase S , et al. Neurotoxicity of intrathecally administered bupivacaine involves the posterior roots/posterior white matter and is milder than lidocaine in rats [J]. Reg Anesth Pain Med , 2005 , 30 ( 5 ) : 464- 472.
10. Hodgson P S , Neal J M , Pollock J E , et al. The neurotox- icity of drugs given intrathecally (spinal) [J]. Anesth Anaig, 1999 , 88(4) : 797-809.
11. Takenami T , Yagishita S , Nara Y , et al. Intrathecal mepiv- acaine and prilocaine are less neurotoxic than lidocaine in a rat intrathecal model [J]. Reg Anesth Pain Med , 2004 , 29(5) : 446-453.
12. Lin M T , Beal M F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases [J]. Nature , 2006 , 443(7113) : 787-795.
13. Johnson M E, Uhl C B , Spittler K H, et al. Mitochondrial injury and caspase activation by the local anesthetic lidocaine [J] . Anesthesiology, 2004,101(5) : 1184-1194.
14. Werdehausen R , Braun S , Essmann F , et al. Lidocaine in- duces apoptosis via the mitochondrial pathway independently of death receptor signaling [J]. Anesthesiology , 2007 , 107 (1 ) : 136-143.