Intranasal immunization with SAG1 protein of Toxoplasma gondii in association with cholera toxin dramatically reduces development of cerebral cysts after oral infection

Infection and Immunity

Volumn 64, Issue 6, 1996, Pages 2158-2166

  Debard, Nathalie ^a   Buzoni Gatel, Dominique ^a   Bout, Daniel ^a  

^a UNIVERSITÉ DE TOURS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 5; PROTEIN SAG 1; PROTOZOAL PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; IMMUNIZATION; INFECTION PREVENTION; INTRANASAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; TOXOPLASMA GONDII; TOXOPLASMOSIS;

EID: 0029886972     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.6.2158-2166.1996     Document Type: Article

References (55)

1. Araujo, F. G., and J. S. Remington. 1984. Partially purified antigen preparations of Tomplasma gondii protect against lethal infection in mice. Infect. Immun. 45:122-126.
2. Bourguin, I., T. Chardès, and D. Bout. 1993. Oral immunization with Toxoplasma gondii antigens in association with cholera toxin induces enhanced protective and cell-mediated immunity in C57BL/6 mice. Infect. Immun. 61:2082-2088.
3. Brinkmann, V., J. S. Remington, and S. D. Sharma. 1993. Vaccination of mice with the protective F3G3 antigen of Toxoplasma gondii activates CD4+ but not CD8+ T cells and induces toxoplasma specific IgG antibody. Mol. Immunol. 30:353-358.
4. Brown, C. R., A. Hunter, R. G. Estes, E. Beckmann, J. Formann, C. David, J. S. Remington, and R. McLeod. 1995. Definitive identification of a gene that confers resistance against Toxoplasma gondii cyst burden and encephalitis. Immunology 85:419-428.
5. Bülow, R., and J. C. Boothroyd. 1991. Protection of mice from fatal Toxoplasma gondii infection by immunization with p30 antigen in liposomes. J. Immunol. 147:3496-3500.
6. Buxton, D, 1993. Toxoplasmosis: the first commercial vaccine. Parasitol. Today 9:335-337.
7. Chardès, T., I. Bourguin, M.-N. Mevelec, J.-F. Dubremetz, and D. Bout. 1990. Antibody responses to Toxoplasma gondii in sera, intestinal secretions, and milk from orally infected mice and characterization of target antigens. Infect. Immun. 58:1240-1246.
8. + gut intraepithelial lymphocytes, lytic for parasite-infected enterocytes. J. Immunol. 153:4596-4603.
9. Couvreur, G., A. Sadak, B. Fortier, and J. F. Dubremetz. 1988. Surface antigens of Toxoplasma gondii. Parasitology 97:1-10.
10. Darcy, F., P. Maes, H. Gras-Masse, C. Auriault, M. Bossus, D. Deslee, I. Godard, M.-F. Cesbron, A. Tartar, and A. Capron. 1992. Protection of mice and nude rats against toxoplasmosis by a multiple antigenic peptide construction derived from Toxoplasma gondii P30 antigen. J. Immunol. 149: 3636-3641.
11. Dimier, I. H., and D. Bout. Submitted for publication.
12. Duquesne, V., C. Auriault, F. Darcy, J.-P. Decavel, and A. Capron. 1990. Protection of nude rats against Toxoplasma infection by excreted-secreted antigen-specific helper T cells. Infect. Immun. 58:2120-2126.
13. Elson, C. O., and W. Ealding. 1984. Cholera toxin did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen. J. Immunol. 133:2892-2897.
14. Elson, C. O., W. Ealding, and J. Lefkowitz. 1984. A lavage technique allowing repeated measurement of IgA antibody in mouse intestinal secretions. J. Immunol. Methods 67:101-108.
15. Frenkel, J. K. 1988. Pathophysiology of toxoplasmosis. Parasitol. Today 4:273-278.
16. Gazzinelli, R. T., E. Y. Denkers, and A. Sher. 1993. Host resistance to Toxoplasma gondii: model for studying the selective induction of cell-mediated immunity by intracellular parasites. Infect. Agents Dis. 2:139-149.
17. Gizurarson, S., S.-I. Tamura, C. Aizawa, and T. Kurata. 1992. Stimulation of the intraepithelial flux of influenza HA vaccine hy cholera toxin B subunit. Vaccine 10:101-106.
18. Hazama, M., A. Mayumi-Aono, T. Miyazaki, S. Hinuma, and Y. Fujisawa. 1993. Intranasal immunization against herpes simplex virus infection by using a recombinant glycoprotein D fused with immunomodulating proteins, the B subunit of Escherichia coli heat-labile enterotoxin and interleukin-2. Immunology 78:643-649.
19. Hirabayashi, Y., H. Kurata, H. Funato, T. Nagamine, C. Aizawa, S.-I. Tamura, K. Shimada, and T. Kurata. 1990. Comparison of intranasal inoculation of influenza HA vaccine combined with cholera toxin B subunit with oral or parenteral vaccination. Vaccine 8:243-248.
20. Hirai, S., T. Yashiki, and H. Mima. 1981. Mechanisms for the enhancement of the nasal absorption of insulin by surfactants. Int. J. Pharm. 9:173-184.
21. Holmgren, J., N. Lycke, and C. Czerkinsky. 1993. Cholera toxin and cholera B subunit as oral-mucosal adjuvant and antigen vector systems. Vaccine 11:1179-1184.
22. Hörnquist, E., and N. Lycke. 1993. Cholera toxin adjuvant greatly promotes antigen priming of T cells. Eur. J. Immunol. 23:2136-2143.
23. Johnson, A. M., P. J. McDonald, and S. H. Neoh. 1983. Monoclonal antibodies to Toxoplasma gondii cell membrane surface antigens protect mice from toxoplasmosis. J. Protozool. 30:351-356.
24. Kasper, L. H., J. C. Crabb, and E. R. Pfefferkorn. 1983. Purification of a major membrane protein of Toxoplasma gondii by immunoabsorption with a monoclonal antibody. J. Immunol. 130:2407-2412.
25. + T cells are cytotoxic against Toxoplasma gondii-infected peritoneal macrophages. J. Immunol. 148:1493-1498.
26. Kazanji, M., F. Laurent, and P. Péry. 1994. Immune responses and protective effect in mice vaccinated orally with surface sporozoite protein of Eimeria falciformis in ISCOMs. Vaccine 12:798-804.
27. Keren, D. F., S. E. Kern, D. H. Bauer, P. J. Scott, and P. Porter. 1982. Direct demonstration in intestinal secretions of an IgA memory response to orally administered Shigella flexneri antigens. J. Immunol. 128:475-479.
28. + T cell immunity against fatal Taxoplasma gondii infection in mice. J. Immunol. 147:3501-3506.
29. + T cell clone protects against acute Toxoplasma gondii infection in mice. J. Immunol. 152:1855-1860.
30. Khan, I. A., T. Matsuura, S. Fonseka, and L. H. Kasper. 1996. Production of nitric oxide (NO) is not essential for protection against acute Toxoplasma gondii infection in IRF-1-/- mice. J. Immunol. 156:636-643.
31. Kuper, C. F., P. J. Koornstra, D. M. H. Hameleers, J. Biewenga, B. J. Spit, A. M. Duijvestijn, P. J. C. van Breda Vriesman, and T. Sminia. 1992. The role of nasopharyngeal lymphoid tissue. Immunol. Today 13:219-224.
32. Lundén, A., K. Lövgren, A. Uggla, and F. G. Araujo. 1993. Immune responses and resistance to Toxoplasma gondii in mice immunized with antigens of the parasite incorporated into immunostimulating complexes. Infect. Immun. 61:2639-2643.
33. Lycke, N., and J. Holmgren. 1987. Long-term cholera antitoxin memory in the gut can be triggered to antibody formation associated with protection within hours of an oral challenge immunization. Scand. J. Immunol. 25:407-412.
34. Mack, D. G., and R. McLeod. 1992. Human Toxoplasma gondii-specific secretory immunoglobulin A reduces T. gondii infection of enterocytes in vitro. J. Clin. Invest. 90:2585-2592.
35. Mariarosaria, M., H. F. Staats, T. Hiroi, R. J. Jackson, M. Coste, P. N. Boyaka, N. Okahashi, M. Yamamoto, H. Kiyono, H. Bluethmann, K. Fujihashi and J. R. McGhee. 1995. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J. Immunol. 155:4621-4629.
36. Michetti, P., M. J. Mahan, J. M. Slauch, J. J. Mekalanos, and M. Neutra. 1992. Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium. Infect. Immun. 60:1786-1792.
37. Mineo, J. R., and L. H. Kasper. 1994. Attachment of Toxoplasma gondii to host cells involves major surface protein, SAG-1 (P30). Exp. Parasitol. 79: 11-20.
38. Mineo, J. R., R. McLeod, D. Mack, J. Smith, I. A. Khan, K. H. Ely, and L. H. Kasper. 1993. Antibodies to Toxoplasma gondii surface protein (SAG-1, P30) inhibit infection of host cells and are produced in murine intestine after peroral infection. J. Immunol. 150:3951-3964.
39. Munoz, E., A. M. Zubiaga, M. Merrow, N. P. Sauter, and B. T. Huber. 1990. Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation. J. Exp. Med. 172:95-103.
40. Ogawa, T., H. Shimauchi, Y. Kusumoto, and S. Hamada. 1990. Humoral immune response to Bacteroides gingivalis fimbrial antigen in mice. Immunology 69:8-13.
41. Pierce, N. F., and W. C. Cray. 1981. Cellular dissemination of priming for a mucosal immune response to cholera toxin in rats. J. Immunol. 127:2461-2464.
42. Quiding, M., I. Nordström, A. Kilander, G. Andersson, L. A. Hanson, J. Holmgren, and C. Czerkinsky. 1991. Intestinal immune responses in humans. Oral cholera vaccination induces strong intestinal antibody responses and interferon-γ production and evokes local immunological memory. J. Clin. Invest. 88:143-148.
43. Remington, J. S., R. McLeod, and G. Desmonts. 1995. Toxoplasmosis, p. 140. In J. S. Remington and J. O. Klein (ed.), Infectious diseases of the fetus and newborn infant, 4th ed. W. B. Saunders Company, Philadelphia.
44. Renegar, K. B., and P. A. Small. 1991. Passive transfer of local immunity to influenza virus infection by IgA antibody. J. Immunol. 146:1972-1978.
45. Snapper, C. M., and J. J. Mond. 1993. Towards a comprehensive view of immunoglobulin switching. Immunol. Today 14:15-17.
46. Suzuki, Y., M. A. Orellana, S. Y. Wong, F. K. Conley, and J. S. Remington. 1993. Susceptibility to chronic infection with Toxoplasma gondii does not correlate with susceptibility to acute infection in mice. Infect. Immun. 61: 2284-2288.
47. Tamura, S.-I., Y. Samegai, H. Kurata, T. Nagamine, C. Aizawa, and T. Kurata. 1988. Protection against influenza virus infection by vaccine inoculated intranasally with cholera toxin B subunit. Vaccine 6:409-413.
48. Tamura, S.-I., Y. Shoji, K. Hasigushi, C. Aizawa, and T. Kurata. 1994. Effects of cholera toxin adjuvant on IgE antibody response to orally or nasally administered ovalbumin. Vaccine 12:1238-1240.
49. Vajdy, M., and N. Y. Lycke. 1992. Cholera toxin promotes long-term immunological memory in the gut mucosa to unrelated immunogens after oral immunization. Immunology 75:488-492.
50. Vajdy, M., and N. Y. Lycke. 1993. Stimulation of antigen-specific T- and B-cell memory in local as well as systemic lymphoid tissues following oral immunization with cholera toxin adjuvant. Immunology 80:197-203.
51. VanCott, J. L., N. Okahashi, M. Yamamoto, M. Marinaro, M. Roberts, S. N. Chatfield, D. W. Pascual, H. Kiyono, and J. R. McGhee. 1995. TH2 phenotype is expressed by high oral dose and TH1 phenotype is expressed by low oral dose of recombinant (r) Salmonella in IFN-γ -/- gene-disrupted mice. Clin. Immun. Immunopathol. 76:29. (Abstract.)
52. Winner, L., III, J. Mack, R. Weltzin, J. J. Mekalanos, J. P. Kraehenbuhl, and M. R. Neutra. 1991. New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection. Infect. Immun. 59:977-982.
53. Wright, P. F., B. R. Murphy, M. Kervina, E. M. Lawrence, M. A. Phelan, and D. T. Karzon. 1983. Secretory immunological response after intranasal inactivated influenza A virus vaccinations: evidence for immunoglobulin A memory. Infect. Immun. 40:1092-1095.
54. Wu, H. Y., and M. W. Russell. 1993. Induction of mucosal immunity by intranasal application of a streptococcal surface protein antigen with the cholera toxin B subunit. Infect. Immun. 61:314-322.
55. Xu-Amano, J., H. Kiyono, R. J. Jackson, H. F. Staats, K. Fujihashi, P. D. Burrows, C. O. Elson, S. Pillai, and J. R. McGhee. 1993. Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J. Exp. Med. 178:1309-1320.