Overexpression of the LKB1 gene inhibits lung carcinoma cell proliferation partly through degradation of c-myc protein

Oncology Reports

Volumn 21, Issue 4, 2009, Pages 925-931

  Liang, Xuan ^a   Nan, Ke Jun ^a   Li, Zhao Lun ^a   Xu, Qing Zhi ^b  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

c Myc; Cell proliferation; ERK1 2; LKB1 STK11; Lung carcinoma; STAT3

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; PROTEASOME INHIBITOR; PROTEIN KINASE LKB1; PROTEIN SERINE THREONINE KINASE; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; STK11 PROTEIN, HUMAN;

ARTICLE; CARCINOMA CELL; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LUNG CARCINOGENESIS; LUNG CARCINOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; GENETICS; LUNG TUMOR; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL PROLIFERATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-MYC; STAT3 TRANSCRIPTION FACTOR;

EID: 67449094283     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000305     Document Type: Article

References (32)

1. Ghaffar H, Sahin F, Sanchez-Cepedes M, et al: LKB1 protein expression in the evolution of glandular neoplasia of the lung. Clin Cancer Res 9: 2998-3003, 2003.
2. Jimenez AI, Fernandez P, Dominguez O, et al: Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3′-phosphate kinase/PTEN pathway. Cancer Res 63: 1382-1388, 2003.
3. Sapkota GP, Kieloch A, Lizcano JM, et al: Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth. J Biol Chem 276: 19469-19482, 2001.
4. Tiainen M, Ylikorkala A and Makela TP: Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. Proc Natl Acad Sci USA 96: 9248-9251, 1999.
5. Tiainen M, Vaahtomeri K, Ylikorkala A, et al: Growth arrest by the LKB1 tumor suppressor: induction of p21 (WAF1/CIP1). Hum Mol Genet 11: 1497-1504, 2002.
6. Marignani PA: LKB1, the multitasking tumour suppressor kinase. J Clin Pathol 58: 15-19, 2005.
7. Xie X, Wang Z and Chen Y: Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction. Mol Cell Biochem 301: 115-122, 2007.
8. Scott KD, Nath-Sain S, Agnew MD, et al: LKB1 catalytically deficient mutants enhance cyclin D1 expression. Cancer Res 67: 5622-5627, 2007.
9. Alessi DR, Sakamoto K, Bayascas JR: LKB1-dependent signaling pathways. Annu Rev Biochem 75: 137-163, 2006.
10. Grandori C, Cowley SM, James LP, et al: The Myc/Max/Mad network and the transcriptional control of cell behavior. Annu Rev Cell Dev Biol 16: 653-699, 2000.
11. Koch HB, Zhang R, Verdoodt B, et al: Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. Cell Cycle 6: 205-217, 2007.
12. Mundschau LJ and Faller DV: Platelet-derived growth factor signal transduction through the interferon-inducible kinase PKR: immediate early gene induction. J Biol Chem 270: 3100-3106, 1995.
13. Partanen JI, Nieminen AI, Makela TP, et al: Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proc Natl Acad Sci USA 104: 14694-14699, 2007.
14. Krupitza G, Grusch M, Braun K, et al: TNFalpha-mediated cell death is independent of cdc25A. Cell Death Differ 5: 758-764, 1998.
15. Mehenni H, Lin-Marq N, Buchet-Poyau K, et al: LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes. Hum Mol Genet 14: 2209-2219, 2005.
16. Qiu W, Schonleben F, Thaker HM, et al: A novel mutation of STK11/ LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma. Oncogene 25: 2937-2942, 2006.
17. Boudeau J, Sapkota G and Alessi DR: LKB1, a protein kinase regulating cell proliferation and polarity. FEBS Lett 546: 159-165, 2003.
18. Katajisto P, Vallenius T, Vaahtomeri K, et al: The LKB1 tumor suppressor kinase in human disease. Biochim Biophys Acta 1775: 63-75, 2007.
19. Hermeking H and Eick D: Mediation of c-Myc-induced apoptosis by p53. Science 265: 2091-2093, 1994.
20. Liao DJ, Natarajan G, Deming SL, et al: Cell cycle basis for the onset and progression of c-Myc-induced, TGFalpha-enhanced mouse mammary gland carcinogenesis. Oncogene 19: 1307-1317, 2000.
21. Wierstra I and Alves J: The c-myc promoter: still MysterY and challenge. Adv Cancer Res 99: 113-333, 2008.
22. Benassi B, Fanciulli M, Fiorentino F, et al: c-Myc phosphorylation is required for cellular response to oxidative stress. Mol Cell 21: 509-519, 2006.
23. D'Agnano I, Valentini A, Fornari C, et al: Myc down-regulation induces apoptosis in M14 melanoma cells by increasing p27(kip1) levels. Oncogene 20: 2814-2825, 2001.
24. Montag DT and Lotze MT: Rapid flow cytometric measurement of cytokine-induced phosphorylation pathways [CIPP] in human peripheral blood leukocytes. Clin Immunol 121: 215-226, 2006.
25. Chang F, Steelman LS, Lee JT, et al: Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia 17: 1263-1293, 2003.
26. Whitmarsh AJ: Examining signaling specificity to transcription factors. Methods 26: 217-225, 2002.
27. Klampfer L: The role of signal transducers and activators of transcription in colon cancer. Front Biosci 13: 2888-2899, 2008.
28. Buettner R, Mora LB and Jove R: Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 8: 945-954, 2002.
29. Kaizu T, Ikeda A, Nakao A, et al: Protection of transplant-induced hepatic ischemia/reperfusion injury with carbon monoxide via MEK/ERK1/2 pathway downregulation. Am J Physiol Gastrointest Liver Physiol 294: G236-G244, 2008.
30. Inamura K, Matsuzaki Y, Uematsu N, et al: Rapid inhibition of MAPK signaling and anti-proliferation effect via JAK/STAT signaling by interferon-alpha in hepatocellular carcinoma cell lines. Biochim Biophys Acta 1745: 401-410, 2005.
31. Shirogane T, Fukada T, Muller JM, et al: Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity 11: 709-719, 1999.
32. Vougier S, Cheung SH, Li L, et al: Anomalous behaviour of the STAT3 binding site in the human c-myc P2 promoter. Biochem Biophys Res Commun 364: 627-632, 2007.