-
2
-
-
11244300732
-
LKB1, the multitasking tumour suppressor kinase
-
Marignani PA (2005) LKB1, the multitasking tumour suppressor kinase. J Clin Pathol 58:15-19
-
(2005)
J Clin Pathol
, vol.58
, pp. 15-19
-
-
Marignani, P.A.1
-
3
-
-
0032495530
-
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
-
Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A, Bignell G, Warren W, Aminoff M, Hoglund P, Jarvinen H, Kristo P, Pelin K, Ridanpaa M, Salovaara R, Toro T, Bodmer W, Olschwang S, Olsen AS, Stratton MR, de la Chapelle A, Aaltonen LA (1998) A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 391:184-187
-
(1998)
Nature
, vol.391
, pp. 184-187
-
-
Hemminki, A.1
Markie, D.2
Tomlinson, I.3
Avizienyte, E.4
Roth, S.5
Loukola, A.6
Bignell, G.7
Warren, W.8
Aminoff, M.9
Hoglund, P.10
Jarvinen, H.11
Kristo, P.12
Pelin, K.13
Ridanpaa, M.14
Salovaara, R.15
Toro, T.16
Bodmer, W.17
Olschwang, S.18
Olsen, A.S.19
Stratton, M.R.20
de la Chapelle, A.21
Aaltonen, L.A.22
more..
-
4
-
-
0031974516
-
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
-
Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Muller O, Back W, Zimmer M (1998) Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet 18:38-43
-
(1998)
Nat Genet
, vol.18
, pp. 38-43
-
-
Jenne, D.E.1
Reimann, H.2
Nezu, J.3
Friedel, W.4
Loff, S.5
Jeschke, R.6
Muller, O.7
Back, W.8
Zimmer, M.9
-
5
-
-
0023192463
-
Increased risk of cancer in the Peutz-Jeghers syndrome
-
Giardiello FM, Welsh SB, Hamilton SR, Offerhaus GJ, Gittelsohn AM, Booker SV, Krush AJ, Yardley JH, Luk GD (1987) Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med 316:1511-1514
-
(1987)
N Engl J Med
, vol.316
, pp. 1511-1514
-
-
Giardiello, F.M.1
Welsh, S.B.2
Hamilton, S.R.3
Offerhaus, G.J.4
Gittelsohn, A.M.5
Booker, S.V.6
Krush, A.J.7
Yardley, J.H.8
Luk, G.D.9
-
6
-
-
0033529838
-
Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest
-
Tiainen M, Ylikorkala A, Makela TP (1999) Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. Proc Natl Acad Sci USA 96:9248-9251
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 9248-9251
-
-
Tiainen, M.1
Ylikorkala, A.2
Makela, T.P.3
-
7
-
-
0037096833
-
Growth arrest by the LKB1 tumor suppressor: Induction of p21(WAF1/CIP1)
-
Tiainen M, Vaahtomeri K, Ylikorkala A, Makela TP (2002) Growth arrest by the LKB1 tumor suppressor: Induction of p21(WAF1/CIP1). Hum Mol Genet 11:1497-1504
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1497-1504
-
-
Tiainen, M.1
Vaahtomeri, K.2
Ylikorkala, A.3
Makela, T.P.4
-
8
-
-
0035980097
-
LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest
-
Marignani PA, Kanai F, Carpenter CL (2001) LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest. J Biol Chem 276:32415-32418
-
(2001)
J Biol Chem
, vol.276
, pp. 32415-32418
-
-
Marignani, P.A.1
Kanai, F.2
Carpenter, C.L.3
-
9
-
-
0035903028
-
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
-
Ylikorkala A, Rossi DJ, Korsisaari N, Luukko K, Alitalo K, Henkemeyer M, Makela TP (2001) Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science 293:1323-1326
-
(2001)
Science
, vol.293
, pp. 1323-1326
-
-
Ylikorkala, A.1
Rossi, D.J.2
Korsisaari, N.3
Luukko, K.4
Alitalo, K.5
Henkemeyer, M.6
Makela, T.P.7
-
10
-
-
0037089467
-
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice
-
Miyoshi H, Nakau M, Ishikawa TO, Seldin MF, Oshima M, Taketo MM (2002) Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res 62:2261-2266
-
(2002)
Cancer Res
, vol.62
, pp. 2261-2266
-
-
Miyoshi, H.1
Nakau, M.2
Ishikawa, T.O.3
Seldin, M.F.4
Oshima, M.5
Taketo, M.M.6
-
11
-
-
33646020680
-
LKB1: A sweet side to Peutz-Jeghers syndrome?
-
Carling D (2006) LKB1: A sweet side to Peutz-Jeghers syndrome? Trends Mol Med 12:144-147
-
(2006)
Trends Mol Med
, vol.12
, pp. 144-147
-
-
Carling, D.1
-
12
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
-
Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, Alessi DR, Hardie DG (2003) Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2:28
-
(2003)
J Biol
, vol.2
, pp. 28
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Makela, T.P.6
Alessi, D.R.7
Hardie, D.G.8
-
13
-
-
10744230065
-
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
-
Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LG, Neumann D, Schlattner U, Wallimann T, Carlson M, Carling D (2003) LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 13:2004-2008
-
(2003)
Curr Biol
, vol.13
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
Leiper, F.C.4
Fryer, L.G.5
Neumann, D.6
Schlattner, U.7
Wallimann, T.8
Carlson, M.9
Carling, D.10
-
14
-
-
12144287284
-
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
-
Lizcano JM, Goransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Makela TP, Hardie DG, Alessi DR (2004) LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/ PAR-1. Embo J 23:833-843
-
(2004)
Embo J
, vol.23
, pp. 833-843
-
-
Lizcano, J.M.1
Goransson, O.2
Toth, R.3
Deak, M.4
Morrice, N.A.5
Boudeau, J.6
Hawley, S.A.7
Udd, L.8
Makela, T.P.9
Hardie, D.G.10
Alessi, D.R.11
-
15
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC (2004) The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 101:3329-3335
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
DePinho, R.A.6
Cantley, L.C.7
-
16
-
-
33645976877
-
AMP-activated protein kinase and type 2 diabetes
-
Musi N (2006) AMP-activated protein kinase and type 2 diabetes. Curr Med Chem 13:583-589
-
(2006)
Curr Med Chem
, vol.13
, pp. 583-589
-
-
Musi, N.1
-
17
-
-
20044370885
-
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
-
Sakamoto K, McCarthy A, Smith D, Green KA, Grahame Hardie D, Ashworth A, Alessi DR (2005) Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. Embo J 24:1810-1820
-
(2005)
Embo J
, vol.24
, pp. 1810-1820
-
-
Sakamoto, K.1
McCarthy, A.2
Smith, D.3
Green, K.A.4
Grahame Hardie, D.5
Ashworth, A.6
Alessi, D.R.7
-
18
-
-
28844433635
-
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310:1642-1646
-
(2005)
Science
, vol.310
, pp. 1642-1646
-
-
Shaw, R.J.1
Lamia, K.A.2
Vasquez, D.3
Koo, S.H.4
Bardeesy, N.5
Depinho, R.A.6
Montminy, M.7
Cantley, L.C.8
-
19
-
-
0032821886
-
Improved packing of poly(ethylenimine)/DNA complexes increases transfection efficiency
-
Godbey WT, Wu KK, Hirasaki GJ, Mikos AG (1999) Improved packing of poly(ethylenimine)/DNA complexes increases transfection efficiency. Gene Ther 6:1380-1388
-
(1999)
Gene Ther
, vol.6
, pp. 1380-1388
-
-
Godbey, W.T.1
Wu, K.K.2
Hirasaki, G.J.3
Mikos, A.G.4
-
20
-
-
33646497429
-
Regulation of adiponectin receptors in hepatocytes by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone
-
Sun X, Han R, Wang Z, Chen Y (2006) Regulation of adiponectin receptors in hepatocytes by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. Diabetologia 49:1303-1310
-
(2006)
Diabetologia
, vol.49
, pp. 1303-1310
-
-
Sun, X.1
Han, R.2
Wang, Z.3
Chen, Y.4
-
21
-
-
0033930950
-
Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene
-
Li D, Burch P, Gonzalez O, Kashork CD, Shaffer LG, Bachinski LL, Roberts R (2000) Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene. Biochem Biophys Res Commun 274:117-123
-
(2000)
Biochem Biophys Res Commun
, vol.274
, pp. 117-123
-
-
Li, D.1
Burch, P.2
Gonzalez, O.3
Kashork, C.D.4
Shaffer, L.G.5
Bachinski, L.L.6
Roberts, R.7
-
22
-
-
0034092911
-
Regulation of the cdk inhibitor p27 and its deregulation in cancer
-
Slingerland J, Pagano M (2000) Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol 183:10-17
-
(2000)
J Cell Physiol
, vol.183
, pp. 10-17
-
-
Slingerland, J.1
Pagano, M.2
-
23
-
-
0034011051
-
Multiple functions of p27(Kip1) and its alterations in tumor cells: A review
-
Sgambato A, Cittadini A, Faraglia B, Weinstein IB (2000) Multiple functions of p27(Kip1) and its alterations in tumor cells: A review. J Cell Physiol 183:18-27
-
(2000)
J Cell Physiol
, vol.183
, pp. 18-27
-
-
Sgambato, A.1
Cittadini, A.2
Faraglia, B.3
Weinstein, I.B.4
-
24
-
-
0035992276
-
The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma
-
Shen Z, Wen XF, Lan F, Shen ZZ, Shao ZM (2002) The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma. Clin Cancer Res 8:2085-2090
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2085-2090
-
-
Shen, Z.1
Wen, X.F.2
Lan, F.3
Shen, Z.Z.4
Shao, Z.M.5
-
25
-
-
33646035501
-
The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6, and Ldb1
-
Setogawa T, Shinozaki-Yabana S, Masuda T, Matsuura K, Akiyama T (2006) The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6, and Ldb1. Biochem Biophys Res Commun 343:1186-1190
-
(2006)
Biochem Biophys Res Commun
, vol.343
, pp. 1186-1190
-
-
Setogawa, T.1
Shinozaki-Yabana, S.2
Masuda, T.3
Matsuura, K.4
Akiyama, T.5
-
26
-
-
0028076764
-
The ancient regulatory-protein family of WD-repeat proteins
-
Neer EJ, Schmidt CJ, Nambudripad R, Smith TF (1994) The ancient regulatory-protein family of WD-repeat proteins. Nature 371:297-300
-
(1994)
Nature
, vol.371
, pp. 297-300
-
-
Neer, E.J.1
Schmidt, C.J.2
Nambudripad, R.3
Smith, T.F.4
-
28
-
-
0035664074
-
WD-repeat proteins: Structure characteristics, biological function, and their involvement in human diseases
-
Li D, Roberts R (2001) WD-repeat proteins: Structure characteristics, biological function, and their involvement in human diseases. Cell Mol Life Sci 58:2085-2097
-
(2001)
Cell Mol Life Sci
, vol.58
, pp. 2085-2097
-
-
Li, D.1
Roberts, R.2
-
29
-
-
0029593456
-
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2
-
Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR (1995) The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell 83:1047-1058
-
(1995)
Cell
, vol.83
, pp. 1047-1058
-
-
Wall, M.A.1
Coleman, D.E.2
Lee, E.3
Iniguez-Lluhi, J.A.4
Posner, B.A.5
Gilman, A.G.6
Sprang, S.R.7
-
30
-
-
0030034646
-
Crystal structure of a G-protein beta gamma dimer at 2.1A resolution
-
Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB (1996) Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Nature 379:369-374
-
(1996)
Nature
, vol.379
, pp. 369-374
-
-
Sondek, J.1
Bohm, A.2
Lambright, D.G.3
Hamm, H.E.4
Sigler, P.B.5
|