Evaluation of bax and bcl-2 expression in odontogenic keratocysts and orthokeratinized odontogenic cysts: A comparison of two cysts

Oral Oncology

Volumn 45, Issue 7, 2009, Pages

  Rangiani, A ^a   Motahhary, P ^b  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Dental Research Center TUMS   (Iran)

Author keywords

Apoptosis; Bax; Bcl 2; Immunohistochemistry; Odontogenic keratocyst; Orthokeratinized odontogenic cyst

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2;

ARTICLE; BASEMENT MEMBRANE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; ODONTOGENIC CYST; ODONTOGENIC KERATOCYST; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; DIAGNOSIS, DIFFERENTIAL; HUMANS; IRAN; ODONTOGENIC CYSTS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 67449091235     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2008.12.007     Document Type: Article

References (40)

1. Philipsen H.P. Om keratocyster (kolesteatom) I kaeberne. Tandlaegeblated 60 (1956) 963-981
2. Wright J.M. The odontogenic keratocyst: orthokeratinized variant. Oral Surg Oral Med Oral Pathol 51 6 (1981) 609-618
3. Siar C.H., and Ng K.H. Orthokeratinized odontogenic keratocyst in Malaysians. Br J Oral Maxillofac Surg 26 (1988) 215-220
4. Kakarantza-Angelopoulou E., and Nicolatou O. Odontogenic keratocyst: clinicopathologic study of 87 cases. J Oral Maxillofac Surg 48 (1990) 593-599
5. Crowley T.E., Kaugars G.E., and Gunsolley J.C. Odontogenic keratocysts: a clinical and histologic comparison of the parakeratin and orthokeratin variants. J Oral Maxillofac Surg 50 1 (1992) 22-26
6. High A.S., Robinson P.A., and Klein C.E. Discrimination of parakeratinised odontogenic keratocysts from other odontogenic and non-odontogenic cyst types by expression of a 38 kd cell-surface glycoprotein. J Oral Pathol Med 22 8 (1993) 363-367
7. Vuhahula E., Nikai H., Ijuhin N., Ogawa I., Takata T., Koseki T., et al. Jaw cysts with orthokeratinization: analysis of 12 cases. J Oral Pathol Med 22 1 (1993) 35-40
8. Li T.J., Kitano M., Chen X.M., Itoh T., Kawashima K., Sugihara K., et al. Orthokeratinized odontogenic cyst: a clinicopathological and immunocytochemical study of 15 cases. Histopathology 32 3 (1998) 242-251
9. da Silva M.J., de Sousa S.O., Corrêa L., Carvalhosa A.A., and De Araújo V.C. Immunohistochemical study of the orthokeratinized odontogenic cyst: a comparison with the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94 6 (2002) 732-737
10. Shear M. The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? part 1. Clinical and early experimental evidence of aggressive behavior. Oral Oncol. 38 (2002) 219-226
11. Myoung H., Hong S.P., Hong S.D., Lee J.I., Lim C.Y., Choung P.H., Lee J.H., Choi J.Y., Seo B.M., and Kim M.J. Odontogenic keratocyst: review of 256 cases for recurrence and clinicopathologic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91 3 (2001) 328-333
12. Brannon R.B. The odontogenic keratocyst. A clinicopathologic study of 312 cases. Part I. Clinical features. Oral Surg Oral Med Oral Pathol 42 1 (1976) 54-72
13. Cohen Jr. M.M. Nevoid basal cell carcinoma syndrome: molecular biology and new hypotheses. Int J Oral Maxillofac Surg 28 3 (1999) 216-223
14. Kichi E., Enokiya Y., Muramatsu T., Hashimoto S., Inoue T., Abiko Y., et al. Cell proliferation, apoptosis and apoptosis-related factors in odontogenic keratocysts and in dentigerous cysts. J Oral Pathol Med 34 5 (2005) 280-286
15. Kakarantza-Angelopoulou E., and Nicolatou O. Opinions regarding: odontogenic keratocyst. J Oral Maxillofac Surg 48 12 (1990) 1353-1354
16. Yoshida H., Onizawa K., and Yusa H. Squamous cell carcinoma arising in association with an orthokeratinized odontogenic keratocyst. Report of a case. J Oral Maxillofac Surg 54 5 (1996) 647-651
17. Williams G.T. Programmed cell death: apoptosis and oncogenesis. Cell 65 7 (1991) 1097-1098
18. Lu Q.L., Abel P., Foster C.S., and Lalani E.N. Bcl-2: role in epithelial differentiation and oncogenesis. Hum Pathol 27 2 (1996) 102-110
19. Hsu Y.T., Wolter K.G., and Youle R.J. Cytosol-to-membrane redistribution of bax and bcl-X(L) during apoptosis. Proc Natl Acad Sci U S A 94 8 (1997) 3668-3672
20. Gross A., Jockel J., Wei M.C., and Korsmeyer S.J. Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J 17 14 (1998) 3878-3885
21. Donovan M., and Cotter T.G. Control of mitochondrial integrity by bcl-2 family members and caspase-independent cell death. Biochim Biophys Acta 1644 2-3 (2004) 133-147
22. Sandra F., Nakamura N., Mitsuyasu T., Shiratsuchi Y., and Ohishi M. Two relatively distinct patterns of ameloblastoma: an anti-apoptotic proliferating site in the outer layer (periphery) and a pro-apoptotic differentiating site in the inner layer (centre). Histopathology 39 1 (2001) 93-98
23. Piattelli A., Fioroni M., and Rubini C. Differentiation of odontogenic keratocysts from other odontogenic cysts by the expression of bcl-2 immunoreactivity. Oral Oncol 34 5 (1998) 404-407
24. Suzuki T., Kumamoto H., Kunimori K., and Ooya K. Immunohistochemical analysis of apoptosis-related factors in lining epithelium of radicular cysts. J Oral Pathol Med 34 1 (2005) 46-52
25. Thosaporn W., Iamaroon A., Pongsiriwet S., and Ng K.H. A comparative study of epithelial cell proliferation between the odontogenic keratocyst, orthokeratinized odontogenic cyst, dentigerous cyst, and ameloblastoma. Oral Dis 10 1 (2004) 22-26
26. Takahashi K., MacDonald D., Murayama Y., and Kinane D. Cell synthesis, proliferation and apoptosis in human dental periapical lesions analysed by in situ hybridisation and immunohistochemistry. Oral Dis 5 4 (1999) 313-320
27. Wolter K.G., Hsu Y.T., Smith C.L., Nechushtan A., Xi X.G., and Youle R.J. Movement of bax from the cytosol to mitochondria during apoptosis. J Cell Biol 139 5 (1997) 1281-1292
28. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev 15 22 (2001) 2922-2933
29. Schinzel A., Kaufmann T., and Borner C. Bcl-2 family members: integrators of survival and death signals in physiology and pathology. Biochim Biophys Acta 1644 2-3 (2004) 95-105 (Review. Erratum in: Biochim Biophys Acta 2004;1692(1):45)
30. Murphy K.M., Streips U.N., and Lock R.B. Bcl-2 inhibits a fas-induced conformational change in the bax N terminus and bax mitochondrial translocation. J Biol Chem 275 23 (2000) 17225-17228
31. Mikhailov V., Mikhailova M., Pulkrabek D.J., Dong Z., Venkatachalam M.A., and Saikumar P. Bcl-2 prevents bax oligomerization in the mitochondrial outer membrane. J Biol Chem 276 21 (2001) 18361-18374
32. Lo Muzio L., Staibano S., Pannone G., Bucci P., Nocini P.F., Bucci E., et al. Expression of cell cycle and apoptosis-related proteins in sporadic odontogenic keratocysts and odontogenic keratocysts associated with the nevoid basal cell carcinoma syndrome. J Dent Res 78 7 (1999) 1345-1353
33. Kolár Z., Geierová M., Bouchal J., Pazdera J., Zboril V., and Tvrdý P. Immunohistochemical analysis of the biological potential of odontogenic keratocysts. J Oral Pathol Med 35 2 (2006) 75-80
34. Papa F., Scacco S., Vergari R., de Benedittis M., Petruzzi M., Lo Muzio L., et al. Expression and subcellular distribution of bcl-2 and BAX proteins in serum-starved human keratinocytes and mouth carcinoma epidermoid cultures. Life Sci 73 22 (2003) 2865-2872
35. Kumamoto H., and Ooya K. Immunohistochemical analysis of bcl-2 family proteins in benign and malignant ameloblastomas. J Oral Pathol Med 28 8 (1999) 343-349
36. Shear M. The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? part 2. Proliferation and genetic studies. Oral Oncol 38 4 (2002) 323-331
37. Janumyan Y.M., Sansam C.G., Chattopadhyay A., Cheng N., Soucie E.L., Penn L.Z., et al. Bcl-xL/bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry. EMBO J 22 20 (2003) 5459-5470
38. Tsujimoto Y., Gorham J., Cossman J., Jaffe E., and Croce C.M. The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 229 4720 (1985) 1390-1393
39. Loro L.L., Vintermyr O.K., Liavaag P.G., Jonsson R., and Johannessen A.C. Oral squamous cell carcinoma is associated with decreased bcl-2/bax expression ratio and increased apoptosis. Hum Pathol 30 9 (1999) 1097-1105
40. Maruoka Y., Harada H., Mitsuyasu T., Seta Y., Kurokawa H., Kajiyama M., et al. Keratinocytes become terminally differentiated in a process involving programmed cell death. Biochem Biophys Res Commun 238 3 (1997) 886-890