In vivo [123I]CNS-1261 binding to D-serine-activated and MK801-blocked NMDA receptors: A storage phosphor imaging study in rats

Synapse

Volumn 63, Issue 7, 2009, Pages 557-564

  Knol, Remco J J ^a,b   De Bruin, Kora ^a   Van Eck Smit, Berthe L F ^a   Pimlott, Sally ^c   Wyper, David J ^c   Booij, Jan ^a,b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b Graduate School Neurosciences   (Netherlands)

^c NHS GREATER GLASGOW AND CLYDE   (United Kingdom)

Author keywords

Alzheimer's disease; Biodistribution; Glutamatergic system; Nuclear medicine; Single photon emission computed tomography (SPECT)

Indexed keywords

CNS 1261; DIZOCILPINE; IODINE 123; N (1 NAPHTHYL) N' (3 IODOPHENYL) N' METHYLGUANIDINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SERINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING COMPETITION; BINDING SITE; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DOSE TIME EFFECT RELATION; DRUG RECEPTOR BINDING; HIPPOCAMPUS; HISTOPATHOLOGY; IN VIVO STUDY; NERVE DEGENERATION; NEUROPROTECTION; NEUROTRANSMITTER RELEASE; NONHUMAN; PHOSPHATE METABOLISM; PHOSPHOR IMAGING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RECEPTOR OCCUPANCY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ADIPOSE TISSUE; ANIMALS; AUTORADIOGRAPHY; BINDING SITES; BLOOD; BRAIN; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID AGENTS; GUANIDINES; HEART; KIDNEY; LUNG; MALE; MUSCLES; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SERINE; SPLEEN; TIME FACTORS;

EID: 67449083630     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20629     Document Type: Article

References (22)

1. 3H]CNS-5161 - A use-dependent ligand for the N-methyl-D-aspartate receptor in rat brain. Synapse 61:577-586.
2. 3H]MK801 binding sites in mammalian brain. Br J Pharmacol 93:944-954. (Pubitemid 18093405)
3. Bressan RA, Pilowsky LS. 2000. Imaging the glutamatergic system in vivo - Relevance to schizophrenia. Eur J Nucl Med 27:1723-1731. (Pubitemid 30812531)
4. 123I]CNS-1261 binding to N-methyl-D-aspartate receptors in vivo. Biol Psychiatry 58:41-46. (Pubitemid 40909934)
5. Danysz W, Parsons CG. 2003. The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: Preclinical evidence. Int J Geriatr Psychiatry 18 (Suppl 1):S23-S32. (Pubitemid 37150475)
6. De Felice FG, Velasco PT, Lambert MP, Viola K, Fernandez SJ, Ferreira ST, Klein WL. 2007. Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J Biol Chem 282:11590-11601.
7. Dingledine R, Borges K, Bowie D, Traynelis SF. 1999. The glutamate receptor ion channels. Pharmacol Rev 51:7-61. (Pubitemid 29113865)
8. 123I]CNS 1261 - A potential SPET tracer for the NMDA receptor. Nucl Med Biol 30:441-454. (Pubitemid 36589052)
9. Javitt DC. 2004. Glutamate as a therapeutic target in psychiatric disorders. Mol Psychiatry 9:979, 984-997. (Pubitemid 39524288)
10. Knol RJ, Doornbos T, van den Bos JC, de Bruin K, Pfaffendorf M, Aanhaanen W, Janssen AG, Vekemans JA, van Eck-Smit BL, Booij J. 2004. Synthesis and evaluation of iodinated TZTP-derivatives as potential radioligands for imaging of muscarinic M2 receptors with SPET. Nucl Med Biol 31:111-123. (Pubitemid 38115131)
11. Knol RJ, de Bruin K, de Jong J, van Eck-Smit BL, Booij J. 2008. In vitro and ex vivo storage phosphor imaging of short-living radioisotopes. J Neurosci Methods 168:341-357.
12. Laruelle M, Kegeles LS, Abi-Dargham A. 2003. Glutamate, dopamine, and schizophrenia: From pathophysiology to treatment. Ann N Y Acad Sci 1003:138-158. (Pubitemid 38083052)
13. Lau CG, Zukin RS. 2007. NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. Nat Rev Neurosci 8:413-426. (Pubitemid 46789232)
14. Lesne S, Ali C, Gabriel C, Croci N, MacKenzie ET, Glabe CG, Plotkine M, Marchand-Verrecchia C, Vivien D, Buisson A. 2005. NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production. J Neurosci 25:9367-9377.
15. 11C] methoxybenzyl) phenyl]-2(1H)-quinolone (AcL703) with positron emission tomography. Synapse 61:795-800. (Pubitemid 47328797)
16. Molinuevo JL, Llado A, Rami L. 2005. Memantine: Targeting glutamate excitotoxicity in Alzheimer's disease and other dementias. Am J Alzheimers Dis Other Demen 20:77-85. (Pubitemid 40547347)
17. Owens J, Wyper DJ, Patterson J, Brown DR, Elliott AT, Teasdale GM, McCulloch J. 1997. First SPET images of glutamate (NMDA) receptor activation in vivo in cerebral ischaemia. Nucl Med Commun 18:149-158. (Pubitemid 27135066)
18. 125I]-CNS 1261): A potential SPECT agent for imaging NMDA receptor activation. Nucl Med Biol 27:557-564. (Pubitemid 30803753)
19. Standridge JB. 2004. Pharmacotherapeutic approaches to the treatment of Alzheimer's disease. Clin Ther 26:615-630. (Pubitemid 38736954)
20. 123I]CNS-1261 in humans in vivo. Nucl Med Biol 33:239-243.
21. 3H]3-OH-PCP (1-(1(3-hydroxyphenyl)cyclohexyl)piperidine) binding sites in rat brain. Brain Res Bull 37:431-435.
22. Waterhouse RN. 2003. Imaging the PCP site of the NMDA ion channel. Nucl Med Biol 30:869-878. (Pubitemid 38040996)