Efficient inhibition of SDF-1α-mediated chemotaxis and HIV-1 infection by novel CXCR4 antagonists

Cancer Science

Volumn 100, Issue 4, 2009, Pages 778-781

  Iwasaki, Yuki ^a   Akari, Hirofumi ^a   Murakami, Tsutomu ^b   Kumakura, Sei ^c   Dewan, Md Zahidunnabi ^b,d   Yanaka, Mikiro ^c   Yamamoto, Naoki ^b  

^a NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c KUREHA CORPORATION   (Japan)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; KRH 1636; KRH 2731; KRH 3148; KRH 3955; STROMAL CELL DERIVED FACTOR 1ALPHA; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ARGININE; BENZYLAMINE DERIVATIVE; CHEMOKINE RECEPTOR CXCR4; DRUG DERIVATIVE; IMIDAZOLE DERIVATIVE; N,N DIPROPYL N' [4 ((((1H IMIDAZOL 2 YL)METHYL)((1 METHYL 1H IMIDAZOL 2 YL) METHYL)AMINO}METHYL)BENZYL) N' METHYLBUTANE 1,4 DIAMINE; N,N-DIPROPYL-N'-[4-((((1H-IMIDAZOL-2-YL)METHYL)((1-METHYL-1H-IMIDAZOL-2-YL) METHYL)AMINO}METHYL)BENZYL)-N'-METHYLBUTANE-1,4-DIAMINE; PYRIDINE DERIVATIVE; STROMAL CELL DERIVED FACTOR 1;

ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METASTASIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; CD4+ T LYMPHOCYTE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; IMMUNOLOGY; LEUKEMIA CELL LINE; METABOLISM; NEUTROPHIL CHEMOTAXIS;

ANTI-HIV AGENTS; ARGININE; BENZYLAMINES; CD4-POSITIVE T-LYMPHOCYTES; CHEMOKINE CXCL12; CHEMOTAXIS, LEUKOCYTE; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV INFECTIONS; HIV-1; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; JURKAT CELLS; PYRIDINES; RECEPTORS, CXCR4;

EID: 67449083566     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2009.01104.x     Document Type: Article

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