Cell biology: Circadian clock control by SUMOylation of BMAL1

Science

Volumn 309, Issue 5739, 2005, Pages 1390-1394

  Cardone, Luca ^a   Hirayama, Jun ^a   Giordano, Francesca ^a   Tamaru, Teruya ^b   Palvimo, Jorma J ^c,d   Sassone Corsi, Paolo ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF HELSINKI   (Finland)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; DIMERIZATION; MOLECULAR BIOLOGY; PROTEINS;

CELL BIOLOGY; CIRCADIAN CLOCK CONTROL; ECTOPIC EXPRESSIONS; REGULATORY FEEDBACK LOOPS;

CELLS;

GREEN FLUORESCENT PROTEIN; HELIX LOOP HELIX PROTEIN; HYBRID PROTEIN; LYSINE; PROTEIN BMAL1; PROTEINASE; SUMO PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CLOCK; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CELL CYCLE PROTEIN; N ETHYLMALEIMIDE; NUCLEAR PROTEIN; PER1 PROTEIN, MOUSE; SUMO 1 PROTEIN; TRANSACTIVATOR PROTEIN;

CIRCADIAN RHYTHM;

ARTICLE; CIRCADIAN RHYTHM; COMPUTER MODEL; FEEDBACK SYSTEM; GENE EXPRESSION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MUTATION; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOPRECIPITATION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; ANIMAL; CELL LINE; CELL STRAIN COS1; CHEMISTRY; DIMERIZATION; GENE EXPRESSION REGULATION; GENETICS; LIVER; METABOLISM; MOUSE; PHOSPHORYLATION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CYCLE PROTEINS; CELL LINE; CIRCADIAN RHYTHM; COS CELLS; DIMERIZATION; ETHYLMALEIMIDE; GENE EXPRESSION REGULATION; LIVER; LYSINE; MICE; MUTATION; NUCLEAR PROTEINS; PHOSPHORYLATION; RECOMBINANT FUSION PROTEINS; SUMO-1 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 23944470712     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1110689     Document Type: Article

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33. We thank C. Bradfield, J. Walisser, U. Schibler, J. Takahashi, N. Kotaja, D. Bailey, F. Melchior, A. Dejean, R. Hay, M. Doi, I. K. Ullas, I. Yujnovsky, and S. Cho for discussions and sharing of reagents and E. Heitz and C. Berling for technical assistance. L.C. is supported by a long-term European Molecular Biology Organization fellowship, J.H. is supported by a fellowship of the Fondation de la Recherche Médicale. Work in our laboratory is supported by Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Centre Hospitalier Universitaire Régional, Fondation de la Recherche Médicale, Université Louis Pasteur, Electricité de France, Association pour la Recherche sur le Cancer, and La Ligue Contre le Cancer.