Simulated moderate altitude elevates serum erythropoietin but does not increase reticulocyte production in well-trained runners

European Journal of Applied Physiology

Volumn 81, Issue 5, 2000, Pages 428-435

  Ashenden, Michael J ^a   Gore, Christopher J ^a   Dobson, Geoffrey P ^b   Boston, Tanya T ^a   Parisotto, Robin ^a   Emslie, Kerry R ^c   Trout, Graham J ^c   Hahn, Allan G ^a  

^a AUSTRALIAN INSTITUTE OF SPORT   (Australia)

^b JAMES COOK UNIVERSITY   (Australia)

^c NATIONAL HEALTH AND MEDICAL RESEARCH COUNCIL   (Australia)

Author keywords

Athletes; Haematology; Nitrogen house; Training

Indexed keywords

ERYTHROPOIETIN; NITROGEN;

ADULT; ALTITUDE; ARTICLE; ATHLETE; BLOOD LEVEL; CONTROLLED STUDY; ERYTHROPOIESIS; HUMAN; HUMAN EXPERIMENT; HYPOXIA; MALE; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RETICULOCYTE; RUNNING; SIMULATION; STIMULATION; TRAINING; VENOUS BLOOD;

EID: 0034126090     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004210050064     Document Type: Article

References (35)

1. Ashenden MJ, Gore CJ, Martin DT, Dobson GP, Hahn AG (1999a) Effects of a 12-day "live high, train low" camp on reticulocyte production and haemoglobin mass in elite female road cyclists. Eur J Appl Physiol 80 472-478
2. Ashenden MJ, Gore CM, Dobson GP, Hahn AG (1999b) "Live high, train low" does not change the total haemoglobin mass of male endurance athletes sleeping at a simulated altitude of 3000 m for 23 nights Eur J Appl Physiol 80 479-484
3. Bailey DM, Davies B (1997) Physiological implications of altitude training for endurance performance at sea level, a review Br J Sports Med 31:183-190
4. Berglund B (1992) High-altitude training. Sports Med 14:289-303
5. Berglund B, Ekblom B (1991) Effect of recombinant human erythropoietin treatment on blood pressure and some haematological parameters in healthy men. J Intern Med 229:125-130
6. Boning D (1997) Altitude and hypoxia training - a short review. Int J Sports Med 18:565-570
7. Bozzini CE, Barcelo AC, Conti MI, Martinez MP, Lezon CE, et al (1997) Unexpected hypoxia-dependent erythropoietin secretion during experimental conditions not affecting tissue oxygen supply/demand ratio. Kidney Int 51:413-415
8. Breyman C, Bauer C, Major A, Zimmermann R, Gautschi K, et al (1996) Optimal timing of repeated rh-erythropoietin administration improves its effectiveness in stimulating erythropoiesis in healthy volunteers. Br J Haematol 92:295-301
9. Brugnara C, Zelmanovic D, Sorette M, Ballas SK, Platt O (1997) Reticulocyte hemoglobin An integrated parameter for evaluation of erythropoietic activity. Am J Clin Pathol 108:133-142
10. Casoni I (1993) Hematological indices of erythropoietin administration in athletes. Int J Sports Med 14:307-311
11. Cazzola M, Mercuriali F, Brugnara C (1997) Use of recombinant human erythropoietin outside the setting of uremia. Blood 89:4248-4267
12. Cazzola M, Guarnone R, Cerani P, Centenara E, Rovati A, et al (1998) Red blood cell precursor mass as an independent determinant of serum erythropoietin level. Blood 91:2139-2145
13. Cerruti A, Castello G, Balleari E, Bogliolo G, Lerza R, et al (1994) Serum erythropoietin increase in patients receiving adjuvant therapy with 5-flourouracil and leucovorin Exp Hematol 22:1261-1263
14. Fisher JW (1993) Recent advances in erythropoietin research Prog Drug Res 41:293-311
15. Fisher JW (1997) Erythropoietin: physiologic and pharmacologic aspects Proc Soc Exp Biol Med 216:358-369
16. Flaherty KK, Caro J, Erslev A, Whalen JJ, Morris EM, et al (1990) Pharmacokinetics and erythropoietic response to human recombinant erythropoietin in healthy men. Clin Pharmacol Ther 47:557-564
17. 2 in National team female endurance athletes during a 7-day "live-high, train-low" camp. 1998 Australian Conference of Science and Medicine in Sport, Adelaide, Australia p 127
18. Gunga H, Kirsch K, Rocker L, Schobersberger W (1994) Time course of erythropoietin, triiodothyronine, thyroxine, and thyroid-stimulating hormone at 2,315 m. J Appl Physiol 76:1068-1072
19. Klausen T, Mohr T, Ghisler U, Nielsen OJ (1991) Maximal oxygen uptake and erythropoietic responses after training at moderate altitude Eur J Appl Physiol 62:376-379
20. Laitinen H, Alopaeus K, Heikkinen R, Hietanen H, Mikkelsson L, et al (1995) Acclimatization to living in normobaric hypoxia and training in normoxia at sea level in runners. Med Sci Sports Exerc 27:S109
21. Levine BD, Stray-Gundersen J, Duhaime G, Snell PG, Friedman DB (1991) "Living high-training low": the effect of altitude acclimatization/normoxic training in trained runners. Med Sci Sports Exerc 23 S25
22. Major A, Bauer C, Breyman C, Huch A, Huch R (1994) rh-Erythropoietin stimulates immature reticulocyte release in man. Br J Haematol 87 605-608
23. Mattila V, Rusko HK (1996) Effect of living high and training low on sea level performance in cyclists. Med Sci Sports Exerc 28 S156
24. McMahon FG, Vargus R, Ryan M, Jain AK, Abels RI, et al (1990) Pharmacokinetics and effects of recombinant human erythropoietin after intravenous and subcutaneous injections in healthy volunteers. Blood 76 1718-1722
25. Piehl Aulin K, Svedenhag J, Wide L, Berglund B, Saltin B (1998) Short-term intermittent normobaric hypoxia - haematological, physiological and mental effects Scand J Med Sci Sports 8:132-137
26. Puranen AS, Rusko HK (1996) On- and off-responses of EPO, reticulocytes, 2,3-DPG and plasma volume to living high, training low. Med Sci Sports Exerc 28 S159
27. Rusko HK, Penttinen JTT, Koistinen PO, Vahasoyrinki PI, Leppaluoto JO (1994) A new solution to simulate altitude and stimulate erythropoiesis at sea level in athletes International Congress on Applied Research in Sports, Helsinki, Finland. pp 287-289
28. Saltin B (1996) Exercise and the environment: focus on altitude. Res Q Exerc Sport 67:1-10
29. Sans T, Bofill C, Joven J, Cliville X, Simo JM, et al (1996) Effectiveness of very low doses of subcutaneous recombinant human erythropoietin in facilitating autologous blood donation before orthopedic surgery. Transfusion 36 822-826
30. Schmidt W, Maassen N, Trost F, Boning D (1988) Training-induced effects on blood volume, erythrocyte turnover and haemoglobin oxygen binding properties. Eur J Appl Physiol 57 490-498
31. Schmidt W, Eckardt KU, Hilgendorf A, Strauch S, Bauer C (1991) Effects of maximal and submaximal exercise under normoxic and hypoxic conditions on serum erythropoietin level. Int J Sports Med 12:457-461
32. Souillard A, Audran M, Bressolle F, Gareau R, Duvallet A, et al (1996) Pharmacokinetics and pharmacodynamics of recombinant human erythropoietin in athletes. Blood sampling and doping control. Br J Clin Pharmacol 42:355-364
33. Stray-Gundersen J, Levine BD (1997) "Living high-training high and low" is equivalent to "living high-training low" for sealevel performance. Med Sci Sports Exerc 29 S136
34. Wide L, Bengtsson C, Berglund B, Ekblom B (1995) Detection in blood and urine of recombinant erythropoietin administered to healthy men. Med Sci Sports Exerc 27 1569-1576
35. Wolski LA, McKenzie DC, Wenger HA (1996) Altitude training for improvements in sea-level performance. Sports Med 22:251-263