Erythropoiesis and performance after two weeks of living high and training low in well trained triathletes

International Journal of Sports Medicine

Volumn 23, Issue 8, 2002, Pages 561-566

  Dehnert, Christoph ^a,c   Hutler M ^b   Liu, Y ^a   Menold, E ^a   Netzer, C ^a   Schick, R ^b   Kubanek, B ^a   Lehmann, M ^a   Boning D ^b   Steinacker, J M ^a  

^a UNIVERSITY OF ULM   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Blood volume; Endurance performance; Erythropoietin; Intermittent hypoxia; Reticulocytes

Indexed keywords

ADULT; ALTITUDE; ALTITUDE ACCLIMATIZATION; ARTICLE; ATHLETE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENDURANCE; EVALUATION; EXERCISE; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; PHYSICAL PERFORMANCE; RANDOMIZED CONTROLLED TRIAL; REBREATHING; RETICULOCYTE; SEA LEVEL; STIMULATION; TRAINING;

ACCLIMATIZATION; ADOLESCENT; ADULT; ALTITUDE; ERYTHROPOIESIS; EXERCISE; FEMALE; HUMANS; MALE; OXYGEN CONSUMPTION; PHYSICAL EDUCATION AND TRAINING; SPORTS; TASK PERFORMANCE AND ANALYSIS;

EID: 18744410640     PISSN: 01724622     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-35533     Document Type: Article

References (53)

1. Alexander JK, Hartley LH, Modelski M, Grover RF. Reduction of stroke volume during exercise in man following ascent to 3100 m altitude. J Appl Physiol 1967; 23: 849-858
2. Ashenden MJ, Gore CJ, Dobson GP, Boston TT, Parisotto R, Emslie KR, Trout GJ, Hahn AG. Simulated moderate altitude elevates serum erythropoietin but does not increase reticulocyte production in well-trained runners. Eur J Appl Physiol 2000; 81: 428-435
3. Ashenden MJ, Gore CJ, Dobson GP, Hahn AG. "Live high, train low" does not change the total haemoglobin mass of male endurance athletes sleeping at a simulated altitude of 3000 m for 23 nights. Eur J Appl Physiol 1999; 80: 479-484
4. Ashenden MJ, Gore CJ, Martin DT, Dobson GP, Hahn AG. Effects of a 12-day "live high, train low" camp on reticulocyte production and haemoglobin mass in elite female road cyclists. Eur J Appl Physiol 1999; 80: 472-478
5. Bailey DM, Davies B. Physiological implications of altitude training for endurance performance at sea level: A review. Br J Sports Med 1997; 31: 183-190
6. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 1986; 60: 2020-2027
7. Berglund B. High-altitude training. Aspects of haematological adaption. Sports Med 1992; 14: 289-303
8. Bigard AX, Brunet A, Guezennec CY, Monod H. Skeletal muscle changes after endurance training at high altitude. J Appl Physiol 1991; 71: 2114-2121
9. Böning D. Altitude and hypoxia training - A short review. Int J Sports Med 1997; 18: 565-570
10. Burge CM, Skinner SL. Determination of hemoglobin mass and blood volume with CO: Evaluation and application of a method. J Appl Physiol 1995; 79: 623-631
11. Chapman RF, Stray-Gundersen J, Levine BD. Individual variation in response to altitude training. J Appl Physiol 1998; 85: 1448-1456
12. Daniels J, Oldridge N. The effects of alternate exposure to altitude and sea level on world-class middle-distance runners. Med Sci Sports Exerc 1970; 2: 107-112
13. Dick FW. Training at altitude in practice. Int J Sports Med 1992; 13: 203-206
14. Digicaylioglu M, Lipton SA. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades. Nature 2001; 412: 641-647
15. Dressendorfer RH, Keen CL, Wade CE, Claybaugh JR, Timmis GC. Development of runner's anemia during a 20-day road face: Effect of iron supplements. Int J Sports Med 1991; 12: 332-336
16. Friedmann BD, Jost J, Rating T, Weller E, Werle E, Eckardt KU, Bärtsch P, Mairbäurl H. Effect of iron supplementation on total body hemoglobin during endurance training at moderate altitude. Int J Sports Med 1999; 20: 78-85
17. Green HJ, Sutton JR, Cymerman A, Young PM, Houston CS. Operation Everest II: Adaptations in human skeletal muscle. J Appl Physiol 1989; 66: 2454-2461
18. Grover RF, Weil JV, Reeves JT. Cardiovascular adaptation to exercise at high altitude. Exerc Sport Sci Rev 1986; 14: 269-30
19. Gunga H, Kirsch K, Rocker L, Schobersberger W. Time course of erythropoietin, triiodothyronine, thyroxine, and thyroid-stimulating hormone at 2315 m. J Appl Physiol 1994; 76: 1068-1072
20. Jackson CG, Sharkey BJ. Altitude, training and human performance. Sports Med 1988; 6: 279-284
21. Jung RC, Dill DB, Horton R, Horvath SM. Effects of age on plasma aldosterone levels and hemoconcentration at altitude. J Appl Physiol 1971; 31: 593-597
22. Kanstrup IL, Ekblom B. Blood volume and hemoglobin concetration as determinants of maximal aerobic power. Med Sci Sports Exerc 1984; 16: 256-262
23. Klausen T, Mohr T, Ghisler U, Nielsen OJ. Maximal oxygen uptake and erythropoietic responses after training at moderate altitude. Eur J Appl Physiol 1991; 62: 376-379
24. Laitinen H, Alopaeus K, Heikkinen R, Hietanen H, Mikkelsson L, Tikkanen H, Rusko HK. Acclimatization to living in normobaric hypoxia and training in normoxia at sea level in runners. Med. Sci Sports Exerc 1995; 27: 109
25. Levine BD, Stray-Gundersen J. "Living high-training low": Effect of moderate altitude acclimatization with low altitude training on performance. J Appl Pysiol 1997; 83: 102-112
26. Levine BD, Stray-Gundersen J. A practical approach to altitude training: Where to live and train for optimal performance enhancement. Int J Sports Med 1992; 13: 209-212
27. Levine BD, Engfred K, Friedman DB, Kjaer M, Saltin B, Clifford PS, Secher NH. High altitude endurance training; effect on aerobic capacity and work performance. Med Sci Sports Exerc 1990; 22: 35
28. Levine BD, Stray-Gundersen J, Duhaime G, Snell PG, Friedman DB. "Living high-training low": The effect of altitude acclimatization normoxic training in trained runners. Med Sci Sports Exerc 1991; 23: 25
29. Liu Y, Steinacker JM, Dehnert C, Menold E, Baur S, Lormes W, Lehmann M. Effect of "living high-training low" on the cardiac functions at sea level. Int J Sports Med 1998; 19: 380-384
30. Mairbäurl H, Schobersberger W, Humpeler E, Hasibeder W, Fischer W, Raas E. Beneficial effects of exercising at moderate altitude on red cell oxygen transport and on exercise performance. Pflügers Arch 1986; 406: 594-599
31. Mattila V, Rusko H. Effect of living high and training low on sea level performance in cyclists. Med Sci Sports Exerc 1996; 28: 156
32. Miayazaki S, Sakai A. The effect of "living high-training low" on physical performance in rats. Int J Biometerol 2000; 44: 24-30
33. Nummela A, Jouste P, Rusko H. Effect of living high and training low on sea level anaerobic performance in runners. Med Sci Sports Exerc 1996; 28: 124
34. Ou LC, Tenney SM. Properties of mitochondria from hearts of cattle acclimatized to high altitude. Respir Physiol 1970; 38: 806-810
35. Piehl Aulin K, Svedenhag J, Wide L, Berglund B, Saltin B. Short-term intermittent normobaric hypoxia - Haematological, physiological and mental effects. Scand J Med Sci Sports 1998; 8: 132-137
36. Puranen AS, Rusko HK. On- and off-response of EPO, reticulocytes, 2,3-DPG and plasma volume to living high, training low. Med Sci Sports Exerc 1996; 28: 159
37. Radomski MW, Sabiston BH, Isoard P. Development of "sports anemia" in physically fit men after daily sustained submaximal exercise. Aviat Space Environ Med 1980; 51: 41-45
38. Roskamm H, Landry F, Samek L, Schlager M, Weidemann H, Reindell H. Effects of a standardized ergometer training program at three different altitudes. J Appl Physiol 1969; 27: 840-847
39. Rusko HK, Penttinen JTT, Koistinen PO, Vahasoyrinki PI, Leppaluoto JO. A new solution to simulate altitude and stimulate erythropoiesis at sea level in athletes. Helsinki, Finland: International Congress on Applied Research in Sports, 1994: pp287-289
40. Schmidt W, Eckhardt KU, Hilgendorf A, Strauch S, Bauer C. Effects of maximal and submaximal exercise under normoxic and hypoxic conditions on serum erythropoietin level. Int J Sports Med 1991; 12: 457-461
41. Schmidt W, Maassen N, Trost E Böning D. Training induced effects on blood volume, erythrocyte turnover and haemoglobin oxygen binding properties. Eur J Appl Physiol 1988; 57: 490-498
42. Souillard A, Audran M, Bressolle F, Gareau R, Duvallet A, Chanal JL. Pharmacokinetics and pharmacodynamics of recombinant human erythropoietin in athletes. Blood sampling and doping control. Br J Clin Pharmacol 1996; 42: 355-364
43. Steinacker JM, Halder A, Liu Y, Thomas A, Stauch M. Hypoxic ventilatory response during rest and exercise after a Himalaya expedition. Eur J Appl Physiol 1996; 73: 202-209
44. Steinacker JM, Liu Y, Böning D, Halder A, Maassen N, Thomas A, Stauch M. Lung diffusion capacity, oxygen uptake, cardiac output and oxygen transport during exercise before and after an Himalaya expedition. Eur J Appl Physiol 1996; 74: 187-193
45. Stray-Gundersen J, Chapman RF, Levine BD. "Living high-training low" altitude training improves sea level performance in male and female elite runners. J Appl Physiol 2001; 91: 1113-1120
46. Stray-Gundersen J, Levine BD. "Living high-training high and low" is equivalent to "living high-training low" for sea-level performance. Med Sci Sports Exerc 1997; 29: S.136
47. Surks MI, Chinn KS, Mathoush LR. Alterations in body composition in man after acute exposure to high altitude. J Appl Physiol 1966; 21: 1741-1746
48. Sutton JR, Reeves JT, Groves BM, Wagner PD, Alexander JK, Hultgren HN, Cymerman A, Houston CS. Oxygen transport and cardiovascular function at extreme altitude: Lessons from Operation Everest II. Int J Sports Med 1992; 13: 13-18
49. Sutton JR, Reeves JT, Wagner PD, Groves BM, Cymerman A, Malconian MK, Rock PB, Young PM, Walter SD, Houston CS. Operation Everest II: Oxygen transport during exercise at extreme simulated altitude. J Appl Physiol 1988; 64: 1309-1321
50. Terrados N. Altitude training and muscular metabolism. Int J Sports Med 1992; 13: 206-209
51. Terrados N, Melichna J, Jansson E, Kaijser L. Effects on training at simulated altitude on performance and muscle metabolic capacity in competitive road cyclists. Eur J Appl Physiol 1988; 57: 203-209
52. Wang RY, Tsai SC, Lu CC, Shih HC, Chen YH, Tung YF, Wang WF, Wang SW, Wang PS. Effect of aging on erythropoietin secretion in male rats. J Gerontol A Bioi Sci Med Sci 1996; 51: B434-438
53. Weight LM, Byrne MJ, Jacobs P. Haemolytic effects of exercise. Clin Sci (Colch) 1991; 81: 147-152