Dexamethasone and betamethasone administration during pregnancy affects expression and function of 11β-hydroxysteroid dehydrogenase type 2 in the rat placenta

Reproductive Toxicology

Volumn 28, Issue 1, 2009, Pages 46-51

  Vackova, Zuzana ^a,c   Vagnerova, Karla ^b   Libra, Antonin ^c   Miksik, Ivan ^b   Pacha, Jiri ^b   Staud, Frantisek ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^c Generi Biotech sro   (Czech Republic)

Author keywords

11 Hydroxysteroid dehydrogenase; Betamethasone; Dexamethasone; Metabolism; Rat placenta

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; BETAMETHASONE; CORTICOSTERONE; DEXAMETHASONE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PLACENTA BARRIER; CONTROLLED STUDY; DRUG DOSE COMPARISON; FEMALE; FETUS; FUNCTIONAL ASSESSMENT; HORMONE METABOLISM; LOW DRUG DOSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLACENTA; PLACENTA FUNCTION; PLACENTA PERFUSION; PREGNANCY OUTCOME; PRENATAL DRUG EXPOSURE; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TERATOGENICITY; WESTERN BLOTTING;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANIMALS; BETAMETHASONE; BIRTH WEIGHT; BLOTTING, WESTERN; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; INJECTIONS, INTRAMUSCULAR; PERFUSION; PLACENTA; PREGNANCY; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

RATTUS;

EID: 67349257944     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2009.02.006     Document Type: Article

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