Functional analysis of the quantitative expression of a costimulatory molecule on dendritic cells using lentiviral vector-mediated RNA interference

Journal of Immunological Methods

Volumn 344, Issue 2, 2009, Pages 87-97

  Zhang, Liang ^a   Procuik, Michele ^a   Fang, Tielan ^a   Kung, Sam Kam Pun ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

CD40; Dendritic cells; Lentiviral vectors; Maturation; RNA interference; Short hairpin RNA

Indexed keywords

CD40 ANTIGEN; LENTIVIRUS VECTOR; LIPOPOLYSACCHARIDE; SHORT HAIRPIN RNA;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; DNA MODIFICATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RNA INTERFERENCE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD40; BASE SEQUENCE; CELL LINE; CELL PROLIFERATION; DENDRITIC CELLS; GENE EXPRESSION; GENETIC VECTORS; HUMANS; INTERLEUKIN-1BETA; LENTIVIRUS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; RNA INTERFERENCE; T-LYMPHOCYTES; TRANSDUCTION, GENETIC;

EID: 67349237153     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jim.2009.03.003     Document Type: Article

References (28)

1. An D.S., Xie Y.M., Mao S.H., Morizono K., Kung S.K.P., and Chen I.S.Y. Efficient lentiviral vectors for short hairpin RNA delivery into human cells. Hum. Gene Ther. 14 (2003) 1207
2. Banchereau J., and Steinman R.M. Dendritic cells and the control of immunity. Nature 392 (1998) 245
3. Bonifaz L., Bonnyay D., Mahnke K., Rivera M., Nussenzweig M.C., and Steinman R.M. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J. Exp. Med. 196 (2002) 1627
4. Fire A. RNA-triggered gene silencing. Trends Genet. 15 (1999) 358
5. Gu X., Xiang J., Yao Y., and Chen Z. Effects of RNA interference on CD80 and CD86 expression in bone marrow-derived murine dendritic cells. Scand. J. Immunol. 64 (2006) 588
6. Haase C., Michelsen B.K., and Jorgensen T.N. CD40 is necessary for activation of naive T cells by a dendritic cell line in vivo but not in vitro. Scand. J. Immunol. 59 (2004) 237
7. Hannon G.J. RNA interference. Nature 418 (2002) 244
8. Hawiger D., Inaba K., Dorsett Y., Guo M., Mahnke K., Rivera M., Ravetch J.V., Steinman R.M., and Nussenzweig M.C. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 194 (2001) 769
9. He Y., Zhang J., Mi Z., Robbins P., and Falo Jr. L.D. Immunization with lentiviral vector-transduced dendritic cells induces strong and long-lasting T cell responses and therapeutic immunity. J. Immunol. 174 (2005) 3808
10. Hill J.A., Ichim T.E., Kusznieruk K.P., Li M., Huang X., Yan X., Zhong R., Cairns E., Bell D.A., and Min W.P. Immune modulation by silencing IL-12 production in dendritic cells using small interfering RNA. J. Immunol. 171 (2003) 691
11. Hoeck J., and Woisetschlager M. STAT6 mediates eotaxin-1 expression in IL-4 or TNF-alpha-induced fibroblasts. J. Immunol. 166 (2001) 4507
12. Inaba K., Inaba M., Romani N., Aya H., Deguchi M., Ikehara S., Muramatsu S., and Steinman R.M. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176 (1992) 1693
13. Kung S.K., Bonifacino A., Metzger M.E., Ringpis G.E., Donahue R.E., and Chen I.S. Lentiviral vector-transduced dendritic cells induce specific T cell response in a nonhuman primate model. Hum. Gene Ther. 16 (2005) 527
14. Laderach D., Compagno D., Danos O., Vainchenker W., and Galy A. RNA interference shows critical requirement for NF-kappa B p50 in the production of IL-12 by human dendritic cells. J. Immunol. 171 (2003) 1750
15. Li M., Qian H., Ichim T.E., Ge W.W., Popov I.A., Rycerz K., Neu J., White D., Zhong R., and Min W.P. Induction of RNA interference in dendritic cells. Immunol. Res. 30 (2004) 215
16. Li M., Zhang X., Zheng X., Lian D., Zhang Z.X., Ge W., Yang J., Vladau C., Suzuki M., Chen D., Zhong R., Garcia B., Jevnikar A.M., and Min W.P. Immune modulation and tolerance induction by RelB-silenced dendritic cells through RNA interference. J. Immunol. 178 (2007) 5480
17. Liu G., Ng H., Akasaki Y., Yuan X., Ehtesham M., Yin D., Black K.L., and Yu J.S. Small interference RNA modulation of IL-10 in human monocyte-derived dendritic cells enhances the Th1 response. Eur. J. Immunol. 34 (2004) 1680
18. Orabona C., Belladonna M.L., Vacca C., Bianchi R., Fallarino F., Volpi C., Gizzi S., Fioretti M.C., Grohmann U., and Puccetti P. Cutting edge: silencing suppressor of cytokine signaling 3 expression in dendritic cells turns CD28-Ig from immune adjuvant to suppressant. J. Immunol. 174 (2005) 6582
19. Qin X.F., An D.S., Chen I.S., and Baltimore D. Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 183
20. Reynolds A., Leake D., Boese Q., Scaringe S., Marshall W.S., and Khvorova A. Rational siRNA design for RNA interference. Nat. Biotechnol (2004)
21. Robbins M.A., and Rossi J.J. Sensing the danger in RNA. Nat. Med. 11 (2005) 250
22. Robertson J.M., Jensen P.E., and Evavold B.D. DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323-339 epitope. J. Immunol. 164 (2000) 4706
23. Scheinecker C., McHugh R., Shevach E.M., and Germain R.N. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J. Exp. Med. 196 (2002) 1079
24. Steinman R.M., Turley S., Mellman I., and Inaba K. The induction of tolerance by dendritic cells that have captured apoptotic cells. J. Exp. Med. 191 (2000) 411
25. Steinman R.M., Hawiger D., and Nussenzweig M.C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21 (2003) 685
26. Stewart S.A., Dykxhoorn D.M., Palliser D., Mizuno H., Yu E.Y., An D.S., Sabatini D.M., Chen I.S., Hahn W.C., Sharp P.A., Weinberg R.A., and Novina C.D. Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA 9 (2003) 493
27. Tran J., and Kung S.K. Lentiviral vectors mediate stable and efficient gene delivery into primary murine natural killer cells. Mol. Ther. 15 (2007) 1331
28. Wilson N.S., El Sukkari D., Belz G.T., Smith C.M., Steptoe R.J., Heath W.R., Shortman K., and Villadangos J.A. Most lymphoid organ dendritic cell types are phenotypically and functionally immature. Blood 102 (2003) 2187