Toxoplasma gondii: Protective effect of an intranasal SAG1 and MIC4 DNA vaccine in mice

Experimental Parasitology

Volumn 122, Issue 3, 2009, Pages 226-232

  Wang, Huaxin ^a   He, Shenyi ^a   Yao, Yuan ^a   Cong, Hua ^a   Zhao, Hong ^a   Li, Ting ^a   Zhu, Xing Quan ^b  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Cholera toxin; DNA vaccine; MIC4; SAG1; Toxoplasma gondii; Toxoplasmosis

Indexed keywords

CHOLERA TOXIN; DNA VACCINE; MEMBRANE PROTEIN; MICRONEME PROTEIN 4; PLASMID DNA; RECOMBINANT SURFACE ANTIGEN 1; TOXOPLASMA GONDII VACCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; FEMALE; HUMORAL IMMUNITY; IMMUNE RESPONSE; LIFE CYCLE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL RATE; TOXOPLASMA GONDII; TOXOPLASMOSIS; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; BLOTTING, WESTERN; CELL ADHESION MOLECULES; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; POLYMERASE CHAIN REACTION; PROTOZOAN PROTEINS; PROTOZOAN VACCINES; TOXOPLASMA; TOXOPLASMOSIS; VACCINES, DNA;

ANIMALIA; EUKARYOTA; MUS; PROTOZOA; TOXOPLASMA GONDII;

EID: 67349232351     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2009.04.002     Document Type: Article

References (43)

1. Alexander J., Jebbari H., Bluethmann H., Satoskar A., and Roberts C.W. Immunological control of Toxoplasma gondii and appropriate vaccine design. Toxoplasma gondii 219 (1996) 183-195
2. Angus C.W., Klivington-Evans D., Dubey J.P., and Kovacs J.A. Immunization with a DNA plasmid encoding the SAG1 (P30) protein of Toxoplasma gondii is immunogenic and protective in rodents. Journal of Infectious Diseases 181 (2000) 317-324
3. Aosai F., Mun H.S., Norose K., Chen M., Hata H., Kobayashi M., Kiuchi M., Stauss H.J., and Yano A. Protective immunity induced by vaccination with SAG1 gene-transfected cells against Toxoplasma gondii-infection in mice. Microbiology and Immunology 43 (1999) 87-91
4. Baudner B.C., Peppoloni S., Ruggiero P., Contorni M., Morandi M., Pizza M., Podda A., Rappuoli R., and Del Giudice G. Safety and immunogenicity in animals of subunit influenza vaccine given intranasally with mutants of Escherichia coli heat-labile enterotoxin (LT). Options for the Control of Influenza V 1263 (2004) 640-643
5. Boehm W., Mertens T., Schirmbeck R., and Reimann J. Routes of plasmid DNA vaccination that prime murine humoral and cellular immune responses. Vaccine 16 (1998) 949-954
6. Bonenfant C., Dimier-Poisson I., Velge-Roussel F., Buzoni-Gatel D., Del Giudice G., Rappuoli R., and Bout D. Intranasal immunization with SAG1 and nontoxic mutant heat-labile enterotoxins protects mice against Toxoplasma gondii. Infection and Immunity 69 (2001) 1605-1612
7. Brecht S., Carruthers V.B., Ferguson D.J.P., Giddings O.K., Wang G., Jakle U., Harper J.M., Sibley L.D., and Soldati D. The toxoplasma micronemal protein MIC4 is an adhesin composed of six conserved apple domains. Journal of Biological Chemistry 276 (2001) 4119-4127
8. Bunnell B.A., and Morgan R.A. Gene therapy for infectious diseases. Clinical Microbiology Reviews 11 (1998) 42-56
9. Buxton D. Protozoan infections (Toxoplasma gondii, Neospora caninum and Sarcocystis spp.) in sheep and goats: recent advances. Veterinary Research 29 (1998) 289-310
10. Couper K.N., Nielsen H.V., Petersen E., Roberts F., Roberts C.W., and Alexander J. DNA vaccination with the immunodominant tachyzoite surface antigen (SAG-1) protects against adult acquired Toxoplasma gondii infection but does not prevent maternofoetal transmission. Vaccine 21 (2003) 2813-2820
11. Cui Y.L., He S.Y., Xue M.F., Zhang J., Wang H.X., and Yao Y. Protective effect of a multiantigenic DNA vaccine against Toxoplasma gondii with co-delivery of IL-12 in mice. Parasite Immunology 30 (2008) 309-313
12. Darcy F., Maes P., Grasmasse H., Auriault C., Bossus M., Deslee D., Godard I., Cesbron M.F., Tartar A., and Capron A. Protection of mice and nude rats against toxoplasmosis by a multiple antigenic peptide construction derived from Toxoplasma gondii P-30 antigen. Journal of Immunology 149 (1992) 3636-3641
13. Debard N., BuzoniGatel D., and Bout D. Intranasal immunization with SAG1 protein of Toxoplasma gondii in association with cholera toxin dramatically reduces development of cerebral cysts after oral infection. Infection and Immunity 64 (1996) 2158-2166
14. Dubey J.P., and Welcome F.L. Toxoplasma gondii - induced abortion in sheep. Journal of the American Veterinary Medical Association 193 (1988) 697-700
15. Fachado A., Rodriguez A., Angel S.O., Pinto D.C., Vila M., Acosta A., Amendoeira R.R., and Lannes-Vieira J. Protective effect of a naked DNA vaccine cocktail against lethal toxoplasmosis in mice. Vaccine 21 (2003) 1327-1335
16. Frenkel J.K., Dubey J.P., and Miller N.L. Toxoplasma gondii in cats. Fecal stages identified as coccidian oocysts. Science 167 (1970) 893-896
17. Hajishengallis G., Hollingshead S.K., Koga T., and Russell M.W. Mucosal immunization with a bacterial protein antigen genetically coupled to cholera-toxin A2/B subunits. Journal of Immunology 154 (1995) 4322-4332
18. Hill D., and Dubey J.P. Toxoplasma gondii: transmission, diagnosis and prevention. Clinical Microbiology and Infection 8 (2002) 634-640
19. Hiramoto R.M., Galisteo A.J., do Nascimento N., and de Andrade H.F. 200 Gy sterilised Toxoplasma gondii tachyzoites maintain metabolic functions and mammalian cell invasion, eliciting cellular immunity and cytokine response similar to natural infection in mice. Vaccine 20 (2002) 2072-2081
20. Keren D.F., McDonald R.A., Scott P.J., Rosner A.M., and Strubel E. Effect of antigen from on local immunoglobulin A memory response of intestinal secretions to Shigella flexneri. Infection and Immunity 47 (1985) 123-128
21. Khan I.A., Ely K.H., and Kasper L.H. A purified parasite antigen (P-30) mediates CD8+ T-cell immunity against fatal Toxoplasma gondii infection in mice. Journal of Immunology 147 (1991) 3501-3506
22. Kravetz J.D., and Federman D.G. Toxoplasmosis in pregnancy. American Journal of Medicine 118 (2005) 212-216
23. Lekutis C., Ferguson D.J.P., Grigg M.E., Camps M., and Boothroyd J.C. Surface antigens of Toxoplasma gondii: variations on a theme. International Journal for Parasitology 31 (2001) 1285-1292
24. Letscher-Bru V., Villard O., Risse B., Zauke M., Klein J.P., and Kien T.T. Protective effect of vaccination with a combination of recombinant surface antigen 1 and interleukin-12 against toxoplasmosis in mice. Infection and Immunity 66 (1998) 4503-4506
25. Liang X.P., Lamm M.E., and Nedrud J.G. Oral-administration of cholera toxin sendai virus conjugate potentiates gut and respiratory immunity against sendai virus. Journal of Immunology 141 (1988) 1495-1501
26. Lourenco E.V., Bernardes E.S., Silva N.A., Mineo J.R., Panunto-Castelo A., and Roque-Barreira M.C. Immunization with MIC1 and MIC4 induces protective immunity against Toxoplasma gondii. Microbes and Infection 8 (2006) 1244-1251
27. Luft B.J., and Hafner R. Toxoplasmic encephalitis. Aids 4 (1990) 593-595
28. Machado C.M., Boas L.S.V., Canto C.L.M., Andrade H.F., Castelli J., Bohringer P., Ostronoff M., Dulley F., and Pannuti C.S. Disseminated toxoplasmosis after BMT-report of a case. Bone Marrow Transplantation 10 (1992) 475-476
29. Martin V., Supanitsky A., Echeverria P.C., Litwin S., Tanos T., De Roodt A.R., Guarnera E.A., and Angel S.O. Recombinant GRA4 or ROP2 protein combined with alum or the gra4 gene provides partial protection in chronic murine models of toxoplasmosis. Clinical and Diagnostic Laboratory Immunology 11 (2004) 704-710
30. McLeod R., Boyer K., Roizen N., Stein L., Swisher C., Holfels E., Hopkins J., Mack D., Karrison T., Patel D., Pfiffner L., Remington J., Withers S., Meyers S., Aitchison V., Mets M., Rabiah P., and Meier P. The child with congenital toxoplasmosis. Current Clinical Topics in Infectious Diseases 20 20 (2000) 189-208
31. Mevelec M.N., Bout D., Desolme B., Marchand H., Magne R., Bruneel O., and Buzoni-Gatel D. Evaluation of protective effect of DNA vaccination with genes encoding antigens GRA4 and SAG1 associated with GM-CSF plasmid, against acute, chronical and congenital toxoplasmosis in mice. Vaccine 23 (2005) 4489-4499
32. Nielsen H.V., Lauemoller S.L., Christiansen L., Buus S., Fomsgaard A., and Petersen E. Complete protection against lethal Toxoplasma gondii infection in mice immunized with a plasmid encoding the SAG1 gene. Infection and Immunity 67 (1999) 6358-6363
33. Petersen E., Nielsen H.V., Christiansen L., and Spenter J. Immunization with E. coli produced recombinant T. gondii SAG1 with alum as adjuvant protect mice against lethal infection with Toxoplasma gondii. Vaccine 16 (1998) 1283-1289
34. Pizza M., Giuliani M.M., Fontana M.R., Monaci E., Douce G., Dougan G., Mills K.H.G., Rappuoli R., and Del Giudice G. Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants. Vaccine 19 (2001) 2534-2541
35. Roberts C.W., Roberts F., Lyons R.E., Kirisits M.J., Mui E.J., Finnerty J., Johnson J.J., Ferguson D.J.P., Coggins J.R., Krell T., Coombs G.H., Milhous W.K., Kyle D.E., Tzipori S., Barnwell J., Dame J.B., Carlton J., and McLeod R. The shikimate pathway and its branches in apicomplexan parasites. Journal of Infectious Diseases 185 (2002) S25-S36
36. Roberts F., and McLeod R. Pathogenesis of toxoplasmic retinochoroiditis. Parasitology Today 15 (1999) 51-57
37. Robinson H.L. Nucleic acid vaccines: an overview. Vaccine 15 (1997) 785-787
38. Ryan E.J., McNeela E., Pizza M., Rappuoli R., O'Neill L., and Mills K.H.G. Modulation of innate and acquired immune responses by Escherichia coli heat-labile toxin: distinct pro- and anti-inflammatory effects of the nontoxic AB complex and the enzyme activity. Journal of Immunology 165 (2000) 5750-5759
39. Tenter A.M., Heckeroth A.R., and Weiss L.M. Toxoplasma gondii: from animals to humans. International Journal for Parasitology 30 (2000) 1217-1258
40. Velge-Roussel F., Marcelo P., Lepage A.C., Buzoni-Gatel D., and Bout D.T. Intranasal immunization with Taxoplasma gondii SAG1 induces protective cells into both NALT and GALT compartments. Infection and Immunity 68 (2000) 969-972
41. Winner L., Mack J., Weltzin R., Mekalanos J.J., Kraehenbuhl J.P., and Neutra M.R. New model for analysis of mucosal immunity-intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection. Infection and Immunity 59 (1991) 977-982
42. Xue M.F., He S.Y., Zhang J., Cui Y.L., Yao Y., and Wang H.X. Comparison of cholera toxin A2/B and murine interleukin-12 as adjuvants of Toxoplasma multi-antigenic SAG1-ROP2 DNA vaccine. Experimental Parasitology 119 (2008) 352-357
43. Zhang J., He S.Y., Jiang H., Yang T.T., Cong H., Zhou H.Y., Zhang J.Q., Gu Q.M., Li Y., and Zhao Q.L. Evaluation of the immune response induced by multiantigenic DNA vaccine encoding SAG1 and ROP2 of Toxoplasma gondii and the adjuvant properties of murine interleukin-12 plasmid in BALB/c mice. Parasitology Research 101 (2007) 331-338