Influence of structural variations on drug release from lipid/polyethylene glycol matrices

European Journal of Pharmaceutical Sciences

Volumn 37, Issue 5, 2009, Pages 555-562

  Windbergs, Maike ^a,b   Strachan, Clare Joanna ^b,c   Kleinebudde, Peter ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Chain length; Dissolution; Molecular weight; Polyethylene glycol; Solid lipid extrusion; Triglyceride

Indexed keywords

FATTY ACID; MACROGOL; THEOPHYLLINE; TRIACYLGLYCEROL; TRILAURIN; TRIPALMITIN; TRISTEARIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG DOSAGE FORM; DRUG RELEASE; DRUG SOLUBILITY; DRUG STORAGE; MELTING POINT; MOLECULAR WEIGHT; PELLET EXTRUSION; POWDER; PRIORITY JOURNAL; REPRODUCIBILITY; TEMPERATURE SENSITIVITY;

ADSORPTION; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG CARRIERS; DRUG STORAGE; FATTY ACIDS; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; POWDER DIFFRACTION; POWDERS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES; THEOPHYLLINE; TRANSITION TEMPERATURE; TRIGLYCERIDES; WATER;

EID: 67349228462     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.04.010     Document Type: Article

References (26)

1. Apicella A., Capello B., Del Nobile M.A., La Rotonda M.I., Mensitieri G., and Nicolais L. Poly(ethylene oxide) (PEO) and different molecular weight PEO blends monolithic devices for drug release. Biomaterials 14 2 (1993) 83-90
2. Breitkreutz J., El Saleh F., Kiera C., Kleinebudde P., and Wiedey W. Pediatric drug formulations of sodium benzoate. II. Coated granules with a lipophilic binder. Eur. J. Pharm. Biopharm. 56 (2003) 255-260
3. Bunjes H., Westensen K., and Koch M.H.J. Crystallization tendency and polymorphic transitions in triglyceride nanoparticles. Int. J. Pharm. 129 (1996) 159-173
4. Chauhan B., Shimpi S., and Paradkar A. Preparation and characterization of etoricoxib solid dispersions using lipid carriers by spray drying technique. AAPS Pharm. Sci. Tech. 6 3 (2005) E405-412
5. Chen W., Zhang X., Shan B., and You X. Methylxanthines. I. Anhydrous theophylline. Acta Cryst. C53 (1997) 777-779
6. Choy Y.W., Khan N., and Yuen K.H. Significance of lipid matrix aging on in vitro release and in vitro bioavailability. Int. J. Pharm. 299 (2005) 55-64
7. Cleek R.L., Ting K.C., Eskin S.G., and Mikos A.G. Microparticles of poly (dl-lactic-co-glycolic-acid)/poly(ethylene glycol) blends for controlled drug delivery. J. Control. Release 48 (1997) 259-268
8. Craig D.Q.M. A review of thermal methods used for the analysis of the crystal form, solution thermodynamics and glass transition behaviour of polyethylene glycols. Thermochim. Acta 248 (1995) 189-203
9. Craig D.Q.M., and Newton J.M. Characterisation of polyethylene glycols using differential scanning calorimetry. Int. J. Pharm. 74 (1991) 33-41
10. Hagemann J.W. Thermal behaviour and polymorphism of acylglycerides. In: Garti N., and Sato K. (Eds). Crystallization and Polymorphism of Fats and Fatty Acids (1988), Marcel Dekker, New York 9-95
11. Herrmann S., Winter G., Mohl S., Siepmann F., and Siepmann J. Mechanisms controlling protein release from lipidic implants: effect of PEG addition. J. Control. Release 118 (2007) 161-168
12. Herrmann S., Mohl S., Siepmann F., Siepmann J., and Winter G. New insight into the role of polyethylene glycol acting as protein release modifier in lipidic implants. Pharm. Res. 24 8 (2007) 1527-1537
13. Humberstone A.J., and Charman W.N. Lipid based vehicles for the oral delivery of poorly water soluble drugs. Adv. Drug Deliv. Rev. 25 (1997) 103-128
14. Khan N., and Craig D.Q.M. Role of blooming in determinig the storage stability of lipid-based dosage forms. J. Pharm. Sci. 93 12 (2004) 2962-2971
15. Liu J., Zhang F., and McGinity J.W. Properties of lipophilic matrix tablets containing phenylpropanololamine hydrochloride prepared by hot-melt extrusion. Eur. J. Pharm. Biopharm. 52 2 (2001) 181-190
16. Maggi L., Segale L., Torre M.L., Ochoa Machiste E., and Conte U. Dissolution behaviour of hydrophilic matrix tablets containing different polyethylene oxides (PEOs) for the controlled release of a water-soluble drug. Dimensional study. Biomaterials 23 (2001) 1113-1119
17. Mehnert W., and Mäder K. Solid lipid nanoparticles-production, characterization and applications. Adv. Drug Deliv. Rev. 47 (2001) 165-196
18. Michalk A., Kanikanti V.R., Hamann H.J., and Kleinebudde P. Controlled release of active as a consequence of the die diameter in solid lipid extrusion. J. Control. Release 132 1 (2008) 35-41
19. Pinto J.F., and Silverio N.P. Assessment of the extrudability of three different mixtures of saturated polyglycolysed glycerides by determination of the "specific work of extrusion" and capillary rheometry. Pharm. Dev. Technol. 6 (2001) 117-128
20. Prabhu S., Ortega M., and Ma C. Novel lipid-based formulations enhancing the in vitro dissolution and permeability characteristics of a poorly water-soluble model drug, piroxicam. Int. J. Pharm. 301 1-2 (2005) 209-216
21. Porter C.J.H., and Charman W.N. In vitro assessment of oral lipid based formulations. Adv. Drug Deliv. Rev. 50 (2001) 127-147
22. Qi S., Deutsch D., and Craig D.Q. An investigation into the mechanisms of drug release from taste-masking fatty acid microspheres. J. Pharm. Sci. 97 9 (2008) 3842-3854
23. Reitz C., and Kleinebudde P. Solid lipid extrusion of sustained release dosage forms. Eur. J. Pharm. Biopharm. 67 (2007) 440-448
24. Windbergs M., Strachan C.J., and Kleinebudde P. Understanding the solid-state behaviour of triglyceride solid lipid extrudates and its influence on dissolution. Eur. J. Pharm. Biopharm. 71 (2009) 80-87
25. Windbergs, M., Strachan, C.J., Kleinebudde, P., 2009b. Influence of the composition of glycerides on the solid-state behaviour and the dissolution profiles of solid lipid extrudates. Int. J. Pharm., doi:10.1016/j.ijpharm.2009.03.002.
26. Windbergs, M., Strachan, C.J., Kleinebudde, P., 2009c. Tailor-made dissolution profiles by extruded matrices based on lipid polyethylene glycol mixtures. J. Control Release, doi:10.1016/j.jconrel.2009.04.002.