3 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis

NeuroImage

Volumn 46, Issue 3, 2009, Pages 633-641

  Neema, Mohit ^a   Goldberg Zimring, Daniel ^a,b   Guss, Zachary D ^a   Healy, Brian C ^a   Guttmann, Charles R G ^a,b   Houtchens, Maria K ^a   Weiner, Howard L ^a   Horsfield, Mark A ^c   Hackney, David B ^d   Alsop, David C ^d   Bakshi, Rohit ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BRAIN ATROPHY; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS CALLOSUM; FEMALE; FRONTAL LOBE; HUMAN; IMAGE ANALYSIS; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PARIETAL LOBE; PRIORITY JOURNAL; WHITE MATTER; ADOLESCENT; ALGORITHM; COMPUTER ASSISTED DIAGNOSIS; IMAGE ENHANCEMENT; METHODOLOGY; MIDDLE AGED; MYELINATED NERVE; PATHOLOGY; REFERENCE VALUE; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; ADULT; ALGORITHMS; FEMALE; HUMANS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; NERVE FIBERS, MYELINATED; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 67349223504     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2009.03.001     Document Type: Article

References (56)

1. Armspach J.P., Gounot D., Rumbach L., and Chambron J. In vivo determination of multiexponential T2 relaxation in the brain of patients with multiple sclerosis. Magn. Reson. Imaging 9 (1991) 107-113
2. Bachmann R., Reilmann R., Schwindt W., Kugel H., Heindel W., and Krämer S. FLAIR imaging for multiple sclerosis: a comparative MR study at 1.5 and 3.0 Tesla. Eur. Radiol. 16 (2006) 915-921
3. Bakshi R., Benedict R.H., Bermel R.A., Caruthers S.D., Puli S.R., Tjoa C.W., Fabiano A.J., and Jacobs L. T2 hypointensity in the deep gray matter of patients with multiple sclerosis: a quantitative magnetic resonance imaging study. Arch. Neurol. 59 (2002) 62-68
4. Bakshi R., Minagar A., Jaisani Z., and Wolinsky J.S. Imaging of multiple sclerosis: role in neurotherapeutics. NeuroRx 2 (2005) 277-303
5. Bakshi R., Thompson A.J., Rocca M.A., Pelletier D., Dousset V., Barkhof F., Inglese M., Guttmann C.R., Horsfield M.A., and Filippi M. MRI in multiple sclerosis: current status and future prospects. Lancet Neurol. 7 (2008) 615-625
6. Barbosa S., Blumhardt L.D., Roberts N., Lock T., and Edwards R.H. Magnetic resonance relaxation time mapping in multiple sclerosis: normal appearing white matter and the "invisible" lesion load. Magn. Reson. Imaging 12 (1994) 33-42
7. Bermel R.A., and Bakshi R. The measurement and clinical relevance of brain atrophy in multiple sclerosis. Lancet Neurol. 5 (2006) 158-170
8. Bermel R.A., Sharma J., Tjoa C.W., Puli S.R., and Bakshi R. A semiautomated measure of whole-brain atrophy in multiple sclerosis. J. Neurol. Sci. 208 (2003) 57-65
9. Breger R.K., Rimm A.A., Fischer M.E., Papke R.A., and Haughton V.M. T1 and T2 measurements on a 1.5-T commercial MR imager. Radiology 171 (1989) 273-276
10. Briellmann R.S., Syngeniotis A., Fleming S., Kalnins R.M., Abbott D.F., and Jackson G.D. Increased anterior temporal lobe T2 times in cases of hippocampal sclerosis: a multi-echo T2 relaxometry study at 3 T. AJNR Am. J. Neuroradiol. 25 (2004) 389-394
11. Cader S., Cifelli A., Abu-Omar Y., Palace J.J., and Matthews P.M. Reduced brain functional reserve and altered functional connectivity in patients with multiple sclerosis. Brain 129 (2006) 527-537
12. Ceccarelli A., Rocca M.A., Falini A., Tortorella P., Pagani E., Rodegher M., Comi G., Scotti G., and Filippi M. Normal-appearing white and grey matter damage in MS. A volumetric and diffusion tensor MRI study at 3.0 Tesla. J. Neurol. 254 (2007) 513-518
13. Craelius W., Migdal M.W., Luessenhop C.P., Sugar A., and Mihalakis I. Iron deposits surrounding multiple sclerosis plaques. Arch. Pathol. Lab. Med. 106 (1982) 397-399
14. Crawley A.P., and Henkelman R.M. Errors in T2 estimation using multislice multiple-echo imaging. Magn. Reson. Med. 4 (1987) 34-47
15. Dalton C.M., Chard D.T., Davies G.R., Miszkiel K.A., Altmann D.R., Fernando K., Plant G.T., Thompson A.J., and Miller D.H. Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes. Brain 127 (2004) 1101-1107
16. de Bazelaire C.M., Duhamel G.D., Rofsky N.M., and Alsop D.C. MR imaging relaxation times of abdominal and pelvic tissues measured in vivo at 3.0 T: preliminary results. Radiology 230 (2004) 652-659
17. Du Y.P., Chu R., Hwang D., Brown M.S., Kleinschmidt-DeMasters B.K., Singel D., and Simon D.H. Fast multislice mapping of the myelin water fraction using multicompartment analysis of T2* decay at 3 T: a preliminary postmortem study. Magn. Reson. Med. 58 (2007) 570-865
18. Evangelou N., Esiri M.M., Smith S., Palace J., and Matthews P.M. Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis. Ann. Neurol. 47 (2000) 391-395
19. Fautz H.P., Büchert M., Husstedt H., Laubenberger J., and Hennig J. TSE sequences with spin-echo contrast. Magn. Reson. Med. 43 (2000) 577-582
20. Gauthier S.A., Glanz B.I., Mandel M., and Weiner H.L. A model for the comprehensive investigation of a chronic autoimmune disease: the multiple sclerosis CLIMB study. Autoimmun. Rev. 5 (2006) 532-536
21. Grenier D., Pelletier D., Normandeau M., Newitt D., Nelson S., Goodkin D.E., and Majumdar S. T2 relaxation time histograms in multiple sclerosis. Magn. Reson. Imaging 20 (2002) 733-741
22. Houtchens M.K., Benedict R.H., Killiany R., Sharma J., Jaisani Z., Singh B., Weinstock-Guttman B., Guttmann C.R., and Bakshi R. Thalamic atrophy and cognition in multiple sclerosis. Neurology 69 (2007) 1213-1223
23. Janardhan V., Suri S., and Bakshi R. Multiple sclerosis: hyperintense lesions in the brain on nonenhanced T1-weighted MR images evidenced as areas of T1 shortening. Radiology 244 (2007) 823-831
24. Kurtzke J.F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33 (1983) 1444-1452
25. Laule C., Vavasour I.M., Moore G.R., Oger J., Li D.K., Paty D.W., and MacKay A.L. Water content and myelin water fraction in multiple sclerosis: a T2 relaxation study. J. Neurol. 251 (2004) 284-293
26. Laule C., Vavasour I.M., Kolind S.H., Traboulsee A.L., Moore G.R., Li D.K., and MacKay A.L. Long T2 water in multiple sclerosis: what else can we learn from multi-echo T2 relaxation?. J. Neurol. 254 (2007) 1579-1587
27. Lawson C.L., and Hanson R.J. Solving Least Squares Problems (1974), Prentice-Hall, Englewood Cliffs, NJ 1-311
28. Majumdar S., Orphanoudakis S.C., Gmitro A., O'Donnell M., and Gore J.C. Errors in the measurements of T2 using multiple-echo MRI techniques. I. Effects of radiofrequency pulse imperfections. Magn. Reson. Med. 3 (1986) 397-417
29. Majumdar S., Orphanoudakis S.C., Gmitro A., O'Donnell M., and Gore J.C. Errors in the measurements of T2 using multiple-echo MRI techniques. II. Effects of static field inhomogeneity. Magn. Reson. Med. 3 (1986) 562-574
30. Melhem E.R., Gotwald T.F., Itoh R., Zinreich S.J., and Moser H.W. T2 relaxation measurements in X-linked adrenoleukodystrophy performed using dual-echo fast fluid-attenuated inversion recovery MR imaging. AJNR Am. J. Neuroradiol. 22 (2001) 773-776
31. Miller D.H., Johnson G., Tofts P.S., MacManus D., and McDonald W.I. Precise relaxation time measurements of normal-appearing white matter in inflammatory central nervous system disease. Magn. Reson. Med. 11 (1989) 331-336
32. Minnerop M., Specht K., Ruhlmann J., Schimke N., Abele M., Weyer A., Wüllner U., and Klockgether T. Voxel-based morphometry and voxel-based relaxometry in multiple system atrophy-a comparison between clinical subtypes and correlations with clinical parameters. NeuroImage 36 (2007) 1086-1095
33. Neema M., Stankiewicz J., Arora A., Dandamudi V.S., Batt C.E., Guss Z.D., Al-Sabbagh A., and Bakshi R. T1- and T2-based MRI measures of diffuse gray matter and white matter damage in patients with multiple sclerosis. J. Neuroimaging 17 (2007) 16S-21S
34. Neema M., Stankiewicz J., Arora A., Guss Z.D., and Bakshi R. MRI in multiple sclerosis: what's inside the toolbox?. Neurotherapeutics 4 (2007) 602-617
35. Oh J., Han E.T., Lee M.C., Nelson S.J., and Pelletier D. Multislice brain myelin water fractions at 3 T in multiple sclerosis. J. Neuroimaging 17 (2007) 156-163
36. Papanikolaou N., Papadaki E., Karampekios S., Spilioti M., Maris T., Prassopoulos P., and Gourtsoyiannis N. T2 relaxation time analysis in patients with multiple sclerosis: correlation with magnetization transfer ratio. Eur. Radiol. 14 (2004) 115-122
37. Parry A., Clare S., Jenkinson M., Smith S., Palace J., and Matthews P.M. MRI brain T1 relaxation time changes in MS patients increase over time in both the white matter and the cortex. J. Neuroimaging 13 (2003) 129-234
38. Polman C.H., Reingold S.C., Edan G., Filippi M., Hartung H.P., Kappos L., Lublin F.D., Metz L.M., McFarland H.F., O'Connor P.W., Sandberg-Wollheim M., Thompson A.J., Weinshenker B.G., and Wolinsky J.S. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann. Neurol. 58 (2005) 840-846
39. Press W., Teukolsky S., Vetterling W., and Flannery B. Numerical Recipes in C. 2nd ed. (1992), Cambridge University Press, Cambridge, UK
40. Sanfilipo M.P., Benedict R.H., Sharma J., Weinstock-Guttman B., and Bakshi R. The relationship between whole brain volume and disability in multiple sclerosis: a comparison of normalized gray vs. white matter with misclassification correction. NeuroImage 26 (2005) 1068-1077
41. Schenck J.F., Zimmerman E.A., Li Z., Adak S., Saha A., Tandon R., Fish K.M., Belden C., Gillen R.W., Barba A., Henderson D.L., Neil W., and O'Keefe T. High-field magnetic resonance imaging of brain iron in Alzheimer disease. Top. Magn. Reson. Imaging 17 (2006) 41-50
42. Schick F. Whole-body MRI at high field: technical limits and clinical potential. Eur. Radiol. 15 (2005) 946-959
43. Sicotte N.L., Voskuhl R.R., Bouvier S., Klutch R., Cohen M.S., and Mazziotta J.C. Comparison of multiple sclerosis lesions at 1.5 and 3.0 Tesla. Invest. Radiol. 38 (2003) 423-427
44. Simon J.H., Kinkel R.P., Jacobs L., Bub L., and Simonian N. A Wallerian degeneration pattern in patients at risk for MS. Neurology 54 (2000) 1155-1160
45. Smith S.A., Edden R.A., Farrell J.A., Barker P.B., and Van Zijl P.C. Measurement of T1 and T2 in the cervical spinal cord at 3 Tesla. Magn. Reson. Med. 60 (2008) 213-219
46. Srinivasan R., Sailasuta N., Hurd R., Nelson S., and Pelletier D. Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T. Brain 128 (2005) 1016-1025
47. Stankiewicz J.M., Glanz B., Healy B.C., Arora A., Neema M., Benedict R.H.B., Guss Z.D., Buckle G.J., Houtchens M.K., Khoury S., Weiner H.L., Guttmann C.R.G., and Bakshi R. Brain MRI lesion volume correlates with physical disability and cognitive impairment in multiple sclerosis: comparison of 1.5 T and 3 T. Neurology 70 (2008) A473
48. Stevenson V.L., Parker G.J., Barker G.J., Birnie K., Tofts P.S., Miller D.H., and Thompson A.J. Variations in T1 and T2 relaxation times of normal appearing white matter and lesions in multiple sclerosis. J. Neurol. Sci. 178 (2000) 81-87
49. Stokes M.E., Davis C.S., and Koch G.G. Categorical Data Analysis Using the SAS System. 2nd ed. (2000), SAS Institute Inc., Cary, NC
50. Tartaglia M.C., Narayanan S., Francis S.J., Santos A.C., De Stefano N., Lapierre Y., and Arnold D.L. The relationship between diffuse axonal damage and fatigue in multiple sclerosis. Arch. Neurol. 61 (2004) 201-207
51. Valsasina P., Benedetti B., Rovaris M., Sormani M.P., Comi G., and Filippi M. Evidence for progressive gray matter loss in patients with relapsing-remitting MS. Neurology 65 (2005) 1126-1128
52. Wattjes M.P., Lutterbey G.G., Harzheim M., Gieseke J., Träber F., Klotz L., Klockgether T., and Schild H.H. Higher sensitivity in the detection of inflammatory brain lesions in patients with clinically isolated syndromes suggestive of multiple sclerosis using high field MRI: an intraindividual comparison of 1.5 T with 3.0 T. Eur. Radiol. 16 (2006) 2067-2073
53. Whittall K.P., and MacKay A.L. Quantitative interpretation of NMR relaxation data. J. Magn. Reson. 84 (1989) 64-71
54. Whittall K.P., MacKay A.L., and Li D.K. Are mono-exponential fits to a few echoes sufficient to determine T2 relaxation for in vivo human brain?. Magn. Reson. Med. 41 (1999) 1255-1257
55. Whittall K.P., MacKay A.L., Li D.K., Vavasour I.M., Jones C.K., and Paty D.W. Normal-appearing white matter in multiple sclerosis has heterogeneous, diffusely prolonged T(2). Magn. Reson. Med. 47 (2002) 403-408
56. Zivadinov R., De Masi R., Nasuelli D., Bragadin L.M., Ukmar M., Pozzi-Mucelli R.S., Grop A., Cazzato G., and Zorzon M. MRI techniques and cognitive impairment in the early phase of relapsing-remitting multiple sclerosis. Neuroradiology 43 (2001) 272-278