Variations in T1 and T2 relaxation times of normal appearing white matter and lesions in multiple sclerosis

Journal of the Neurological Sciences

Volumn 178, Issue 2, 2000, Pages 81-87

  Stevenson, V L ^a   Parker, G J M ^a   Barker, G J ^a   Birnie, K ^a   Tofts, P S ^a   Miller, D H ^a   Thompson, A J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

FLAIR; MRI; Multiple Sclerosis; T1 relaxation times; T2 relaxation times

Indexed keywords

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMAGE ANALYSIS; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE; POSTERIOR FOSSA; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RELAXATION TIME; SEQUENCE ANALYSIS; TISSUE SPECIFICITY; WHITE MATTER;

BRAIN; HUMANS; MAGNETIC RESONANCE IMAGING; MULTIPLE SCLEROSIS; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS;

EID: 0034665243     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(00)00339-7     Document Type: Article

References (21)

1. Breger R.K., Rimm A.A., Fischer M.E., Papke R.A., Haughton V.M. T1 and T2 measurements on a commercial MR imager. Radiology. 171:1989;273-276.
2. Larsson H.B.W., Christiansen P., Zeeberg I., Henriksen O. In vivo evaluation of the reproducibility of T1 and T2 measured in the brain of patients with multiple sclerosis. Magn. Reson. Imaging. 10:1992;579-584.
3. Miller D.H., Johnson G., Tofts P.S., MacManus D., McDonald W.I. Precise relaxation time measurements of normal-appearing white matter in inflammatory central nervous system disease. Magn. Reson. Medicine. 11:1989;331-336.
4. Steen R.G., Gronemeyer S.A., Kingsley P.B., Reddick W.E., Langston J.S., Taylor J.S. Precise and accurate measurement of proton T1 in human brain in vivo: validation and preliminary clinical application. JMRI. 4:1994;681-691.
5. Armspach J., Gounot D., Rumbach L., Chambron J. In vivo determination of multiexponential T2 relaxation times in the brains of patients with multiple sclerosis. Magn. Reson. Imaging. 9:1991;107-113.
6. Barbosa S., Blumhardt L.D., Roberts N., Lock T., Edwards R.H.T. Magnetic resonance relaxation time mapping in multiple sclerosis normal appearing white matter and the ’invisible’ lesion load. Magn. Reson. Imaging. 12:1994;33-42.
7. Lacomis D., Osbakken M., Gross G. Spin lattice relaxation (T1) times of cerebral white matter in multiple sclerosis. Magn. Reson. Medicine. 3:1986;194-202.
8. Larsson H.B.W., Frederiksen J., Kjaer L., Henriksen O., Olesen J. In vivo determination of T1 and T2 in the brain of patients with severe but stable multiple sclerosis. Magn. Reson. Medicine. 7:1988;43-55.
9. Ormerod I.E.C., Miller D.H., McDonald W.I., du Boulay E.P., Rudge P., Kendall B.E., Moseley I.F., Johnson G., Tofts P.S., Halliday A.M., Bronstein A.M., Scaravilli F., Harding A.E., Barnes D., Zilkha K.J. The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological lesions. A quantitative study. Brain. 110:1987;1579-1616.
10. Rumbach L., Armspach J., Gounot D., Namer I.J., Chambron J., Warter J., Collard M. Nuclear magnetic resonance T2 relaxation times in multiple sclerosis. J. Neurol. Sci. 104:1991;176-181.
11. Larsson H.B.W., Frederiksen J., Petersen J., Nordenbo A., Zeeberg I., Henriksen O., Olesen J. Assessment of demyelination, edema, and gliosis by in vivo determination of T1 and T2 in the brain of patients with acute attack of multiple sclerosis. Magn. Reson. Medicine. 11:1989;337-348.
12. Kidd D., Barker G.J., Tofts P.S., Gass A., Thompson A.J., Miller D.H. The transverse magnetisation decay characteristics of longstanding lesions and normal-appearing white matter in multiple sclerosis. J. Neurol. 244:(2):1997;125-130.
13. Gawne-Cain M.L., O’Riordan J.I., Thompson A.J., Moseley I.F., Miller D.H. Multiple sclerosis lesion detection in the brain: A comparison of fast fluid-attenuated inversion recovery and conventional T2-weighted dual spin echo. Neurology. 49:1997;364-370.
14. Stevenson V.L., Gawne-Cain M.L., Barker G.J., Thompson A.J., Miller D.H. Imaging of the spinal cord and brain in multiple sclerosis: a comparative study between fast flair and fast spin echo. J. Neurol. 244:(2):1997;119-124.
15. Parker GJM, Barker GJ, Tofts PS. Accurate multislice T1 measurement in the presence of non-ideal R.F. pulse profiles and R.F. field inhomogeneity. 8th Annual meeting of the ISMRM, Philadelphia 1999.
16. Thompson A.J., Kermode A.G., Wicks D., MacManus D.G., Kendall B.E., Kingsley D.P., McDonald W.I. Major differences in the dynamics of primary and secondary progressive multiple sclerosis. Ann. Neurol. 29:1991;53-62.
17. Allen I.V., McKeown S.R. A histological, histochemical and biochemical study of the macroscopically normal white matter in multiple sclerosis. J. Neurol. Sci. 41:(1):1979;81-91.
18. Trapp B.D., Peterson J., Ransohoff R.M., Rudick R., Mork S., Bo L. Axonal transection in the lesions of multiple sclerosis. N. Engl. J. Med. 338:(5):1998;278-285.
19. Gass A., Neff K.W., Hennerici M.G., Schwartz A. Assessment of acute and chronic optic nerve, brainstem and spinal cord lesions in M.S. patients on T1-weighted images. Eur. J. Neurol. 3:(Supplement 4):1996;8-9.
20. McDonald W.I., Miller D.H., Barnes D. The pathological evolution of multiple sclerosis. Neuropathol. Appl. Neurobiol. 18:(4):1992;319-334.
21. Truyen L., van Waesberghe J.H.T.M., van Walderveen M.A.A., van Oosten B.W., Polman C.H., Hommes O.R., Ader H.J.A., Barkhof F. Accumulation of hypointense lesions (’black holes’) on T1 spin-echo MRI correlates with disease progression in multiple sclerosis. Neurology. 47:(6):1996;1469-1476.