Water content and myelin water fraction in multiple sclerosis: A T 2 relaxation study

Journal of Neurology

Volumn 251, Issue 3, 2004, Pages 284-293

  Laule, C ^a   Vavasour, I M ^a   Moore, G R W ^a   Oger, J ^a   Li, D K B ^a   Paty, D W ^a   MacKay, A L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Brain; Magnetic resonance imaging; Multiple sclerosis; Myelin; Normal appearing white matter

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEMYELINATING DISEASE; DEMYELINATION; FEMALE; HUMAN; MALE; MULTIPLE SCLEROSIS; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; WATER CONTENT; WHITE MATTER;

ADULT; BRAIN; ECHO-PLANAR IMAGING; FEMALE; HUMANS; MALE; MIDDLE AGED; MODELS, NEUROLOGICAL; MULTIPLE SCLEROSIS; MYELIN SHEATH; WATER;

EID: 1642413441     PISSN: 03405354     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00415-004-0306-6     Document Type: Article

References (51)

1. Allen IV, Glover G, Anderson R (1981) Abnormalities in the macroscopically normal white matter in cases of mild or spinal multiple sclerosis (MS). Acta Neuropathol - Supplementum (Berl) 7:176-178
2. Allen IV, McKeown SR (1979) A histological, histochemical and biochemical study of the macroscopically normal white matter in multiple sclerosis. J Neurol Sci 41:81-91
3. Allen IV, McQuaid S, Mirakhur M, Nevin G (2001) Pathological abnormalities in the normal-appearing white matter in multiple sclerosis. Neurol Sci 22:141-144
4. Alling C, Vanier MT, Svennerholm L (1971) Lipid alterations in apparently normal white matter in multiple sclerosis. Brain Res 35:325-336
5. The IFNB Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group (1995) Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. Neurology 45:1277-1285
6. Bammer R, Augustin M, Strasser-Fuchs S, Seifert T, Kapeller P, Stollberger R, Ebner F, Hartung HP, Fazekas F (2000) Magnetic resonance diffusion tensor imaging for characterizing diffuse and focal white matter abnormalities in multiple sclerosis. Magn Reson Med 44:583-591
7. Barnes D, Munro PM, Youl BD, Prineas JW, McDonald WI (1991) The long-standing MS lesion. A quantitative MRI and electron microscopic study. Brain 114:1271-1280
8. Bitsch A, Kuhlmann T, Da Costa C, Bunkowski S, Polak T, Bruck W (2000) Tumour necrosis factor alpha mRNA expression in early multiple sclerosis lesions: correlation with demyelinating activity and oligodendrocyte pathology. Glia 29:366-375
9. Brooks RA, Di Chiro G, Keller MR (1980) Explanation of cerebral white-gray contrast in computed tomography. J Comput Assist Tomog 4:489-491
10. Castriota-Scanderbeg A, Sabatini U, Fasano F, Floris R, Fraracci L, Mario MD, Nocentini U, Caltagirone C (2002) Diffusion of water in large demyelinating lesions: a follow-up study. Neuroradiology 44:764-767
11. Cercignani M, Inglese M, Pagani E, Comi G, Filippi M (2001) Mean diffusivity and fractional anisotropy histograms of patients with multiple sclerosis. AJNR: Am J Neuroradiol 22:952-958
12. th Annual Meeting of the American Academy of Neurology, Denver, Colorado
13. De Stefano N, Narayanan S, Francis GS, Arnaoutelis R, Tartaglia MC, Antel JP, Matthews PM, Arnold DL (2001) Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability. Arch Neurol 58:65-70
14. Evangelou N, Esiri MM, Smith S, Palace J, Matthews PM (2000) Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis. Ann Neurol 47:391-395
15. Evangelou N, Konz D, Esiri MM, Smith S, Palace J, Matthews PM (2000) Regional axonal loss in the corpus callosum correlates with cerebral white matter lesion volume and distribution in multiple sclerosis. Brain 123:1845-1849
16. Fatouros PP, Marmarou A (1999) Use of magnetic resonance imaging for in vivo measurements of water content in human brain: method and normal values. J Neurosurg 90:109-115
17. Fewster ME, Hirono H, Mead JF (1976) Lipid composition of myelin in multiple sclerosis. J Neurol 213:119-131
18. Filippi M, Iannucci G, Cercignani M, Assunta Rocca M, Pratesi A, Comi G (2000) A quantitative study of water diffusion in multiple sclerosis lesions and normal-appearing white matter using echo-planar imaging. Arch Neurol 57:1017-1021
19. Gareau PJ, Rutt BK, Bowen CV, Karlik SJ, Mitchell JR (1999) In vivo measurements of multi-component T2 relaxation behaviour in guinea pig brain. Magn Reson Imaging 17:1319-1325
20. Gareau PJ, Rutt BK, Karlik SJ, Mitchell JR (2000) Magnetization transfer and multicomponent T2 relaxation measurements with histopathologic correlation in an experimental model of MS. J Magn Reson Imaging 11:586-595
21. Gasperini C, Horsfield MA, Thorpe JW, Kidd D, Barker GJ, Tofts PS, MacManus DG, Thompson AJ, Miller DH, McDonald WI (1996) Macroscopic and microscopic assessments of disease burden by MRI in multiple sclerosis: relationship to clinical parameters. J Magn Reson Imaging 6:580-584
22. Ge Y, Grossman RI, Udupa JK, Babb JS, Nyul LG, Kolson DL (2001) Brain atrophy in relapsing-remitting multiple sclerosis: fractional volumetric analysis of gray matter and white matter. Radiology 220:606-610
23. Griffin CM, Chard DT, Parker GJ, Barker GJ, Thompson AJ, Miller DH (2002) The relationship between lesion and normal appearing brain tissue abnormalities in early relapsing remitting multiple sclerosis. J Neurol 249:193-199
24. Itoyama Y, Sternberger NH, Webster HD, Quarles RH, Cohen SR, Richardson EP, Jr. (1980) Immunocytochemical observations on the distribution of myelin-associated glycoprotein and myelin basic protein in multiple sclerosis lesions. Ann Neurol 7:167-177
25. Kapeller P, Brex P, Chard D, Dalton C, Griffin C, McLean M, Parker G, Thompson A, Miller D (2002) Quantitative H-1 MRS imaging 14 years after presenting with a clinically isolated syndrome suggestive of multiple sclerosis. Mult Scler 8:207-210
26. Keegan BM, Noseworthy JH (2002) Multiple sclerosis. Ann Rev Med 53:285-302
27. Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444-1452
28. Larsson HB, Barker GJ, MacKay A (1998) Nuclear magnetic resonance relaxation in multiple sclerosis. J Neurol Neurosurg Psychiatry 64:S70-76
29. Lublin FD, Reingold SC (1996) Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 46:907-911
30. Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H (1999) A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases. Brain 122:2279-2295
31. MacKay A, Whittall K, Adler J, Li D, Paty D, Graeb D (1994) In vivo visualization of myelin water in brain by magnetic resonance. Magn Reson Med 31:673-677
32. McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, McFarland HF, Paty DW, Polman CH, Reingold SC, Sandberg-Wollheim M, Sibley W, Thompson A, van den Noort S, Weinshenker BY, Wolinsky JS (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 50:121-127
33. Mews I, Bergmann M, Bunkowski S, Gullotta F, Bruck W (1998) Oligodendrocyte and axon pathology in clinically silent multiple sclerosis lesions. Mult Scler 4:55-62
34. Moore GR (1998) Neuropathology and Pathophysiology of the Multiple Sclerosis Lesion. In: Paty D, Ebers GC (eds) Multiple Sclerosis. FA. Davis, Philadelphia
35. Moore GR, Leung E, MacKay AL, Vavasour IM, Whittall KP, Cover KS, Li DK, Hashimoto SA, Oger J, Sprinkle TJ, Paty DW (2000) A pathology-MRI study of the short-T2 component in formalin-fixed multiple sclerosis brain. Neurology 55:1506-1510
36. th edn. Raven Press Ltd, New York, pp 109-136
37. nd edn. Plenum Press, New York, pp 147-195
38. Paty DW, Li DK (1993) Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group. Neurology 43:662-667
39. Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13:227-231
40. Raine CS, Cannella B, Hauser SL, Genain CP (1999) Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: a case for antigen-specific antibody mediation. Ann Neurol 46:144-160
41. Rooney W, Springer C, Telang F, Krupp L, Coyle P (2002) Comparison of Brain 4T T1 Histograms between Multiple Sclerosis and Control Subjects. Mult Scler 8:80
42. Santos AC, Narayanan S, de Stefano N, Tartaglia MC, Francis SJ, Arnaoutelis R, Caramanos Z, Antel JP, Pike GB, Arnold DL (2002) Magnetization transfer can predict clinical evolution in patients with multiple sclerosis. J Neurol 249:662-668
43. Sarchielli P, Presciutti O, Pelliccioli GP, Tarducci R, Gobbi G, Chiarini P, Alberti A, Vicinanza F, Gallai V (1999) Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients. Brain 122:513-521
44. Suzuki K, Kamoshita S, Eto Y, Tourtellotte WW, Gonatas JO (1973) Myelin in multiple sclerosis. Composition of myelin from normal-appearing white matter. Arch Neurol 28:293-297
45. Thompson AJ, Miller D, Youl B, MacManus D, Moore S, Kingsley D, Kendall B, Feinstein A, McDonald WI (1992) Serial gadolinium-enhanced MRI in relapsing/remitting multiple sclerosis of varying disease duration. Neurology 42:60-63
46. Tortorella C, Viti B, Bozzali M, Sormani MP, Rizzo G, Gilardi MF, Comi G, Filippi M (2000) A magnetization transfer histogram study of normal-appearing brain tissue in MS. Neurology 54:186-193
47. Tourtellotte W, Parker J (1968) Some spaces and barriers in postmortem multiple sclerosis. Progr Brain Res 29:493-525
48. st Annual Meeting of the White Matter Study Group, Bordeaux, France
49. Werring DJ, Clark CA, Droogan AG, Barker GJ, Miller DH, Thompson AJ (2001) Water diffusion is elevated in widespread regions of normal-appearing white matter in multiple sclerosis and correlates with diffusion in focal lesions. Mult Scler 7:83-89
50. Whittall KP, MacKay AL, Graeb DA, Nugent RA, Li DK, Paty DW (1997) In vivo measurement of T2 distributions and water contents in normal human brain. Magn Reson Med 37:34-43
51. Whittall KP, MacKay AL, Li DK, Vavasour IM, Jones CK, Paty DW (2002) Normal-appearing white matter in multiple sclerosis has heterogeneous, diffusely prolonged T(2). Magn Reson Med 47:403-408