Violations of the 12/23 rule at the mouse immunoglobulin kappa locus, including Vκ-Vκ rearrangement

Molecular Immunology

Volumn 46, Issue 11-12, 2009, Pages 2183-2189

  Vinocur, Jeffrey M ^a   Fesnak, Andrew D ^a   Liu, Yang ^a   Charan, Deepshikha ^a   Luning Prak, Eline T ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Antibodies; B cells; Gene rearrangement; Molecular biology; RAG; V(D)J Recombination

Indexed keywords

IMMUNOGLOBULIN KAPPA CHAIN; NUCLEOTIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE LOCUS; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC RECOMBINATION; GENOTYPE; HYBRIDOMA; IN VIVO STUDY; INTRON; MOLECULAR CLONING; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SPLEEN CELL;

ANIMALS; BASE SEQUENCE; GENE REARRANGEMENT; HYBRIDOMAS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; RECOMBINATION, GENETIC; SPLEEN;

MURINAE;

EID: 67349209606     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.04.021     Document Type: Article

References (36)

1. Brekke K.M., and Garrard W.T. Assembly and analysis of the mouse immunoglobulin kappa gene sequence. Immunogenetics 56 (2004) 490-505
2. Chen C., Nagy Z., Prak E.L., and Weigert M. Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity 3 (1995) 747-755
3. Chothia C., and Lesk A.M. Canonical structures for the hypervariable regions of immunoglobulins. J. Mol. Biol. 196 (1987) 901-917
4. Feddersen R.M., Martin D.J., and Van Ness B.G. Novel recombinations of the IG kappa-locus that result in allelic exclusion. J. Immunol. 145 (1990) 745-750
5. Feddersen R.M., and Van Ness B.G. Double recombination of a single immunoglobulin kappa-chain allele: implications for the mechanism of rearrangement. Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 4793-4797
6. Gellert M. Molecular analysis of V(D)J recombination. Annu. Rev. Genet. 26 (1992) 425-446
7. Gerstein R.M., and Lieber M.R. Coding end sequence can markedly affect the initiation of V(D)J recombination. Genes Dev. 7 (1993) 1459-1469
8. Grillot D.A., Merino R., Pena J.C., Fanslow W.C., Finkelman F.D., Thompson C.B., and Nunez G. bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice. J. Exp. Med. 183 (1996) 381-391
9. Hesse J.E., Lieber M.R., Gellert M., and Mizuuchi K. Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals. Cell 49 (1987) 775-783
10. Hiom K., and Gellert M. Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination. Mol. Cell 1 (1998) 1011-1019
11. Hiom K., Melek M., and Gellert M. DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations. Cell 94 (1998) 463-470
12. Hirama T., Takeshita S., Yoshida Y., and Yamagishi H. Structure of extrachromosomal circular DNAs generated by immunoglobulin light chain gene rearrangements. Immunol. Lett. 27 (1991) 19-23
13. Ippolito G.C., Pelkonen J., Nitschke L., Rajewsky K., and Schroeder Jr. H.W. Antibody repertoire in a mouse with a simplified D(H) locus: the D-limited mouse. Ann. N. Y. Acad. Sci. 987 (2003) 262-265
14. Kabat E.A., Wu T.T., Bilofsky H., Reid-Milner M., and Perry H. Sequences of Proteins of Immunological Interest. 3rd Edition (1983), Public Heath Service, Washington, D.C.
15. Kelley D.E., Wiedemann L.M., Pittet A.C., Strauss S., Nelson K.J., Davis J., Van Ness B., and Perry R.P. Nonproductive kappa immunoglobulin genes: recombinational abnormalities and other lesions affecting transcription, RNA processing, turnover, and translation. Mol. Cell Biol. 5 (1985) 1660-1675
16. Kohler G. Immunoglobulin chain loss in hybridoma lines. Proc. Natl. Acad. Sci. U. S. A. 77 (1980) 2197-2199
17. Koralov S.B., Novobrantseva T.I., Hochedlinger K., Jaenisch R., and Rajewsky K. Direct in vivo VH to JH rearrangement violating the 12/23 rule. J. Exp. Med. 201 (2005) 341-348
18. Langerak A.W., Nadel B., De Torbal A., Wolvers-Tettero I.L., van Gastel-Mol E.J., Verhaaf B., Jager U., and van Dongen J.J. Unraveling the consecutive recombination events in the human IGK locus. J. Immunol. 173 (2004) 3878-3888
19. Li H., Jiang Y., Prak E.L., Radic M., and Weigert M. Editors and editing of anti-DNA receptors. Immunity 15 (2001) 947-957
20. Lieber M.R., Hesse J.E., Mizuuchi K., and Gellert M. Studies of V(D)J recombination with extrachromosomal substrates. Curr. Top. Microbiol. Immunol. 137 (1988) 94-99
21. Martin T., Blaison G., Levallois H., and Pasquali J.L. Molecular analysis of the V kappa III-J kappa junctional diversity of polyclonal rheumatoid factors during rheumatoid arthritis frequently reveals N addition. Eur. J. Immunol. 22 (1992) 1773-1779
22. Meier J.T., and Lewis S.M. P nucleotides in V(D)J recombination: a fine-structure analysis. Mol. Cell Biol. 13 (1993) 1078-1092
23. Milstein C., Even J., Jarvis J.M., Gonzalez-Fernandez A., and Gherardi E. Non-random features of the repertoire expressed by the members of one V kappa gene family and of the V-J recombination. Eur. J. Immunol. 22 (1992) 1627-1634
24. Neiditch M.B., Lee G.S., Huye L.E., Brandt V.L., and Roth D.B. The V(D)J recombinase efficiently cleaves and transposes signal joints. Mol. Cell 9 (2002) 871-878
25. Luning Prak E., Trounstine M., Huszar D., and Weigert M. Light chain editing in kappa-deficient animals: a potential mechanism of B cell tolerance. J. Exp. Med. 180 (1994) 1805-1815
26. Sakano H., Huppi K., Heinrich G., and Tonegawa S. Sequences at the somatic recombination sites of immunoglobulin light-chain genes. Nature 280 (1979) 288-294
27. Sakano H., Kurosawa Y., Weigert M., and Tonegawa S. Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes. Nature 290 (1981) 562-565
28. Schlissel M.S., and Baltimore D. Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription. Cell 58 (1989) 1001-1007
29. Seidman J.G., and Leder P. A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events. Nature 286 (1980) 779-783
30. Sekiguchi D.R., Yunk L., Gary D., Charan D., Srivastava B., Allman D., Weigert M.G., and Prak E.T. Development and selection of edited B cells in B6.56R mice. J. Immunol. 176 (2006) 6879-6887
31. Shapiro M.A., and Weigert M. How immunoglobulin V kappa genes rearrange. J. Immunol. 139 (1987) 3834-3839
32. Shimizu T., Iwasato T., and Yamagishi H. Deletions of immunoglobulin C kappa region characterized by the circular excision products in mouse splenocytes. J. Exp. Med. 173 (1991) 1065-1072
33. Thiebe R., Schable K.F., Bensch A., Brensing-Kuppers J., Heim V., Kirschbaum T., Mitlohner H., Ohnrich M., Pourrajabi S., Roschenthaler F., Schwendinger J., Wichelhaus D., Zocher I., and Zachau H.G. The variable genes and gene families of the mouse immunoglobulin kappa locus. Eur. J. Immunol. 29 (1999) 2072-2081
34. Tonegawa S. Somatic generation of antibody diversity. Nature 302 (1983) 575-581
35. van Gent D.C., Ramsden D.A., and Gellert M. The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell 85 (1996) 107-113
36. Victor K.D., Vu K., and Feeney A.J. Limited junctional diversity in kappa light chains. Junctional sequences from CD43+B220+ early B cell progenitors resemble those from peripheral B cells. J. Immunol. 152 (1994) 3467-3475