Overexpression of suppressor of cytokine signaling 1 in islet grafts results in anti-apoptotic effects and prolongs graft survival

Life Sciences

Volumn 84, Issue 23-24, 2009, Pages 810-816

  Qin, Jie ^a   Jiao, Yang ^b   Chen, Xiaobo ^b   Zhou, Shuang ^a   Liang, Chunmin ^a   Zhong, Cuiping ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Apoptosis; Diabetes; Gene therapy; Islet transplantation; SOCS1

Indexed keywords

ADENOVIRUS VECTOR; ADENOVIRUS VECTOR AD5F35; SUPPRESSOR OF CYTOKINE SIGNALING 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL ISOLATION; CELL TRANSPLANTATION; CONTROLLED STUDY; DIABETES MELLITUS; EMBRYO; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; GRAFT SURVIVAL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; ISLET TRANSPLANTATION; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; GENE EXPRESSION REGULATION; GRAFT SURVIVAL; HUMANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; RATS; RATS, SPRAGUE-DAWLEY; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

ADENOVIRIDAE; RATTUS;

EID: 67349192627     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2009.03.010     Document Type: Article

References (39)

1. Barshes N.R., Wyllie S., and Goss J.A. Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: Implications for intrahepatic grafts. Journal of Leukocyte Biology 77 5 (2005) 587-597
2. Biarnés M., Montolio M., Nacher V., Raurell M., Soler J., and Montanya E. Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long- term hyperglycemia. Diabetes 51 1 (2002) 66-72
3. Chong M.M., Thomas H.E., and Kay T.W. Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor. The Journal of Biological Chemistry 277 31 (2002) 27945-27952
4. Chong M.M., Chen Y., Darwiche R., Dudek N.L., Irawaty W., Santamaria P., Allison J., Kay T.W., and Thomas H.E. Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction. Journal of Immunology 172 9 (2004) 5714-5721
5. Conget J.I., Sarri Y., González-Clemente J.M., Casamitjana R., Vives M., and Gomis R. Deleterious effect of dithizone-DMSO staining on insulin secretion in rat and human pancreatic islets. Pancreas 9 2 (1994) 157-160
6. Contreras J.L., Bilbao G., Smyth C., Eckhoff D.E., Xiang X.L., Jenkins S., Cartner S., Curiel D.T., Thomas F.T., and Thomas J.M. Gene transfer of the Bcl-2 gene confers cytoprotection to isolated adult porcine pancreatic islets exposed to xenoreactive antibodies and complement. Surgery 130 2 (2001) 166-174
7. Contreras J.L., Bilbao G., Smyth C.A., Jiang X.L., Eckhoff D.E., Jenkins S.M., Thomas F.T., Curiel D.T., and Thomas J.M. Cytoprotection of pancreatic islets before and soon after transplantation by gene transfer of the anti-apoptotic Bcl-2 gene. Transplantation 71 8 (2001) 1015-1023
8. Davalli A.M., Ogawa Y., Ricordi C., Scharp D.W., Bonner-Weir S., and Weir G.C. A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice. Transplantation 59 6 (1995) 817-820
9. Emamaullee J.A., and Shapiro A.M. Interventional strategies to prevent beta-cell apoptosis in islet transplantation. Diabetes 55 7 (2006) 1907-1914
10. Emamaullee J., Liston P., Korneluk R.G., Shapiro A.M., and Elliott J.F. XIAP overexpression in islet beta-cells enhances engraftment and minimizes hypoxia-reperfusion injury. American Journal of Transplantation 5 6 (2005) 1297-1305
11. Emamaullee J.A., Rajotte R.V., Liston P., Korneluk R.G., Lakey J.R., Shapiro A.M., and Elliott J.F. XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes. Diabetes 54 9 (2005) 2541-2548
12. Flodström-Tullberg M., Yadav D., Hägerkvist R., Tsai D., Secrest P., Stotland A., and Sarvetnick N. Target cell expression of suppressor of cytokine signaling-1 prevents diabetes in the NOD mouse. Diabetes 52 11 (2003) 2696-2700
13. Giuliani M., Moritz W., Bodmer E., Dindo D., Kugelmeier P., Lehmann R., Gassmann M., Groscurth P., and Weber M. Central necrosis in isolated hypoxic human pancreatic islets: Evidence for postisolation ischemia. Cell Transplantation 14 1 (2005) 67-76
14. Grey S.T., Longo C., Shukri T., Patel V.I., Csizmadia E., Daniel S., Arvelo M.B., Tchipashvili V., and Ferran C. Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function. Journal of Immunology 170 12 (2003) 6250-6256
15. Hogan A., Pileggi A., and Ricordi C. Transplantation: Current developments and future directions; the future of clinical islet transplantation as a cure for diabetes. Frontiers in Bioscience 13 (2008) 1192-1205
16. Kile B.T., and Alexander W.S. The suppressors of cytokine signalling (SOCS). Cellular and Molecular Life Sciences 58 11 (2001) 1627-1635
17. Kimura A., Naka T., Nagata S., Kawase I., and Kishimoto T. SOCS-1 suppresses TNF-alpha-induced apoptosis through the regulation of Jak activation. International Immunology 16 7 (2004) 991-999
18. Klein D., Ribeiro M.M., Mendoza V., Jayaraman S., Kenyon N.S., Pileggi A., Molano R.D., Inverardi L., Ricordi C., and Pastori R.L. Delivery of Bcl-XL or its BH4 domain by protein transduction inhibits apoptosis in human islets. Biochemical and Biophysical Research Communications 323 2 (2004) 473-478
19. Kubo M., Hanada T., and Yoshimura A. Suppressors of cytokine signaling and immunity. Nature Immunology 4 12 (2003) 1169-1176
20. Lakey J.R., Burridge P.W., and Shapiro A.M. Technical aspects of islet preparation and transplantation. Transplant International 16 9 (2003) 613-632
21. Lepore D.A., Shinkel T.A., Fisicaro N., Mysore T.B., Johnson L.E., d'Apice A.J., and Cowan P.J. Enhanced expression of glutathione peroxidase protects islet beta cells from hypoxia-reoxygenation. Xenotransplantation 11 1 (2004) 53-59
22. Merani S., and Shapiro A.M. Current status of pancreatic islet transplantation. Clinical Science (London) 110 6 (2006) 611-625
23. Mizuguchi H., and Hayakawa T. Adenovirus vectors containing chimeric type 5 and type 35 fiber proteins exhibit altered and expanded tropism and increase the size limit of foreign genes. Gene 285 1-2 (2002) 69-77
24. Moriscot C., Pattou F., Kerr-Conte J., Richard M.J., Lemarchand P., and Benhamou P.Y. Contribution of adenoviral-mediated superoxide dismutase gene transfer to the reduction in nitric oxide-induced cytotoxicity on human islets and INS-1 insulin-secreting cells. Diabetologia 43 5 (2000) 625-631
25. Nilsson M., Ljungberg J., Richter J., Kiefer T., Magnusson M., Lieber A., Widegren B., Karlsson S., and Fan X. Development of an adenoviral vector system with adenovirus serotype 35 tropism; efficient transient gene transfer into primary malignant hematopoietic cells. The Journal of Gene Medicine 6 6 (2004) 631-641
26. Paraskevas S., Maysinger D., Wang R., Duguid T.P., and Rosenberg L. Cell loss in isolated human islets occurs by apoptosis. Pancreas 20 3 (2000) 270-276
27. Pileggi A., Molano R.D., Berney T., Cattan P., Vizzardelli C., Oliver R., Fraker C., Ricordi C., Pastori R.L., Bach F.H., and Inverardi L. Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation. Diabetes 50 9 (2001) 1983-1991
28. Plesner A., Liston P., Tan R., Korneluk R.G., and Verchere C.B. The X-linked inhibitor of apoptosis protein enhances survival of murine islet allografts. Diabetes 54 9 (2005) 2533-2540
29. Reffet S., and Thivolet C. Immunology of pancreatic islet transplantation. Diabetes & Metabolism 32 5 Pt 2 (2006) 523-526
30. Ryan E.A., Paty B.W., Senior P.A., Bigam D., Alfadhli E., Kneteman N.M., Lakey J.R., and Shapiro A.M. Five-year follow-up after clinical islet transplantation. Diabetes 54 7 (2005) 2060-2069
31. Sass G., Shembade N.D., and Tiegs G. Tumour necrosis factor alpha (TNF)-TNF receptor 1-inducible cytoprotective proteins in the mouse liver: Relevance of suppressors of cytokine signalling. The Biochemical Journal 385 Pt 2 (2005) 537-544
32. Shapiro A.M., Gallant H.L., Hao E.G., Lakey J.R., McCready T., Rajotte R.V., Yatscoff R.W., and Kneteman N.M. The portal immunosuppressive storm: Relevance to islet transplantation?. Therapeutic Drug Monitoring 27 1 (2005) 35-37
33. Shapiro A.M., Ricordi C., Hering B.J., Auchincloss H., Lindblad R., Robertson R.P., Secchi A., Brendel M.D., Berney T., Brennan D.C., Cagliero E., Alejandro R., Ryan E.A., DiMercurio B., Morel P., Polonsky K.S., Reems J.A., Bretzel R.G., Bertuzzi F., Froud T., Kandaswamy R., Sutherland D.E., Eisenbarth G., Segal M., Preiksaitis J., Korbutt G.S., Barton F.B., Viviano L., Seyfert-Margolis V., Bluestone J., and Lakey J.R. International trial of the Edmonton protocol for islet transplantation. The New England Journal of Medcine 355 13 (2006) 1318-1330
34. Solomon M., Flodström-Tullberg M., and Sarvetnick N. Differences in suppressor of cytokine signaling-1 (SOCS-1) expressing islet allograft destruction in normal BALB/c and spontaneously-diabetic NOD recipient mice. Transplantation 79 9 (2005) 1104-1109
35. Sutton R., Peters M., McShane P., Gray D.W., and Morris P.J. Isolation of rat pancreatic islets by ductal injection of collagenase. Transplantation 42 6 (1986) 689-691
36. Tai J.H., Foster P., Rosales A., Feng B., Hasilo C., Martinez V., Ramadan S., Snir J., Melling C.W., Dhanvantari S., Rutt B., and White D.J. Imaging islets labeled with magnetic nanoparticles at 1.5 Tesla. Diabetes 55 11 (2006) 2931-2938
37. van der Windt D.J., Bottino R., Casu A., Campanile N., and Cooper D.K. Rapid loss of intraportally transplanted islets: An overview of pathophysiology and preventive strategies. Xenotransplantation 14 4 (2007) 288-297
38. Wang H., Lee S.S., Gao W., Czismadia E., McDaid J., Ollinger R., Soares M.P., Yamashita K., and Bach F.H. Donor treatment with carbon monoxide can yield islet allograft survival and tolerance. Diabetes 54 5 (2005) 1400-1406
39. Yasukawa H., Sasaki A., and Yoshimura A. Negative regulation of cytokine signaling pathways. Annual Review of Immunology 18 (2000) 143-164