Concept of a selective tumour therapy and its evaluation by near-infrared fluorescence imaging and flat-panel volume computed tomography in mice

European Journal of Radiology

Volumn 70, Issue 2, 2009, Pages 286-293

  Alves, Frauke ^a,b   Dullin, Christian ^a   Napp, Joanna ^b   Missbach Guentner, Jeannine ^a   Jannasch, Katharina ^a   Mathejczyk, Julia ^b   Pardo, Luis A ^b   Stühmer, Walter ^b   Tietze, Lutz F ^c  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Antibody directed enzyme prodrug therapy; Flat panel volume computed tomography; Near infrared fluorescence imaging; Preclinical imaging; Targeted therapies

Indexed keywords

ANTIBODY DIRECTED ENZYME PRODRUG THERAPY; FLAT-PANEL VOLUME COMPUTED TOMOGRAPHY; NEAR-INFRARED FLUORESCENCE IMAGING; PRECLINICAL IMAGING; TARGETED THERAPIES;

CHEMOTHERAPY; COMPUTERIZED TOMOGRAPHY; DRUG DELIVERY; ENZYMES; FLUORESCENCE; INFRARED DEVICES; MONOCLONAL ANTIBODIES; TOMOGRAPHY;

TUMORS;

BIOLOGICAL MARKER; CANCER ANTIBODY; CONTRAST MEDIUM; DUOCARMYCIN SA; EAG 1 PROTEIN; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; TUMOR ANTIGEN; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ANTIBODY DIRECTED ENZYME PRODRUG THERAPY; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; CANCER THERAPY; CLINICAL EVALUATION; DIAGNOSTIC IMAGING; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG SELECTIVITY; DRUG TARGETING; FLAT PANEL VOLUME COMPUTED TOMOGRAPHY; HUMAN; IC 50; KINETICS; NEAR INFRARED FLUORESCENCE IMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MEDICINE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIODIAGNOSIS; TUMOR CELL; TUMOR GROWTH;

ANIMALS; MICE; MICROSCOPY, FLUORESCENCE; MOLECULAR PROBE TECHNIQUES; NEOPLASMS; PROGNOSIS; RADIOLOGY INFORMATION SYSTEMS; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME; WHOLE BODY IMAGING;

EID: 67349188036     PISSN: 0720048X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejrad.2009.01.048     Document Type: Article

References (39)

1. Pastan I., Hassan R., FritzGerald D.J., and Kreitman R.J. Immunotoxin treatment of cancer. Annu Rev Med 58 (2007) 221-237
2. Kerbel R.S. Antiangiogenic therapy: a universal chemosensitization strategy for cancer. Science 312 (2006) 1171-1175
3. Dziadek S., Hobel A., Schmitt E., and Kunz H. A fully synthetic vaccine consisting of a tumor-associated glycopeptide antigen and a T-cell epitope for the induction of a highly specific humoral immune response. Angew Chem 117 46 (2005) 7803-7808
4. Crespo A., Zhang X., and Fernàndez A. Redesigning kinase inhibitors to enhance specificity. J Med Chem 51 16 (2008) 4890-4898
5. Tietze L.F., Panknin O., Major F., and Krewer B. Synthesis of a novel pentagastrin-drug conjugate for a targeted tumor therapy. Chemistry 14 9 (2008) 2811-2818
6. Falciani C., Fabbrini M., Pini A., et al. Synthesis and biological activity of stable branched neurotensin peptides for tumor targeting. Mol Cancer Ther 6 9 (2007) 2441-2448
7. Bagshawe K.D. Antibody-directed enzyme prodrug therapy (ADEPT) for cancer. Expert Rev Anticancer Ther 6 10 (2006) 1421-1431
8. Tietze L.F., and Feuerstein T. Enzyme and proton-activated prodrugs for a selective cancer therapy. Curr Pharm Des 9 26 (2003) 2155-2175
9. Ross J.S., Gray K., Schenkein D., et al. Antibody based therapeutics in oncology. Expert Rev Anticancer Ther 3 1 (2003) 107-121
10. Deonarain M.P. Recombinant antibodies for cancer therapy. Expert Opin Biol Ther 8 8 (2008) 1123-1141
11. Weissleder R., and Pittet M.J. Imaging in the era of molecular oncology. Nature 452 7187 (2008) 580-589
12. Greschus S., Kiessling F., Lichy M.P., et al. Potential applications of flat-panel volumetric CT in morphologic and functional small animal imaging. Neoplasia 7 8 (2005) 730-740
13. Kiessling F., Greschus S., Lichy M.P., et al. Volumetric computed tomography (VCT): a new technology for noninvasive, high-resolution monitoring of tumor angiogenesis. Nat Med 10 10 (2005) 1133-1138
14. Tietze L.F., von Hof J.M., Krewer B., et al. Asymmetric synthesis and biological evaluation of new glycosidic prodrugs for a selective cancer therapy. Chem Med Chem 3 12 (2008) 1946-1955
15. Tietze L.F., Feuerstein T., Fecher A., et al. Proof of principle in the selective treatment of cancer by antibody-directed enzyme prodrug therapy: the development of a highly potent prodrug. Angew Chem Int Ed Engl 41 5 (2002) 759-761
16. Tietze L.F., Schuster H.J., Schmuck K., Schuberth I., and Alves F. Duocarmycin-based prodrugs for cancer prodrug monotherapy. Bioorg Med Chem 16 12 (2008) 6312-6318
17. Sharma S.K., Pedley R.B., Bhatia J., et al. Sustained tumor regression of human colorectal cancer xenografts using a multifunctional mannosylated fusion protein in antibody-directed enzyme prodrug therapy. Clin Cancer Res 11 2 Pt 1 (2005) 814-825
18. Mello de Queiroz F., Suarez-Kurtz G., Stühmer W., and Pardo L.A. Ether-á-go-go potassium channel expression in soft tissue sarcoma patients. Mol Cancer 5 5 (2006) 42
19. Hemmerlein B., Weseloh R.M., Queiroz FMd, et al. Overexpression of Eag1 potassium channels in clinical tumour specimens. Mol Cancer 5 5 (2006) 41
20. Borsi L., Balza E., Bestagno M., et al. Selective targeting of tumoral vasculature: comparison of different formats of an antibody (L19) to the ED-B domain of fibronectin. Int J Cancer 102 1 (2002) 75-85
21. Tarli L., Balza E., Viti F., et al. A high-affinity human antibody that targets tumoral blood vessels. Blood 94 1 (1999) 192-198
22. Licha K. Contrast agents for optical imaging. In: Krause W. (Ed). Topics in current chemistry vol. 222-contrast agents II (2002), Springer, Heidelberg 1-29
23. 3 expression with Cy7-labeled RGD multimers. Mol Imaging Biol 8 4 (2006) 226-236
24. Schroeter M.R., Sudholt P., Leifheit M., et al. Leptin enhances recruitment of endothelial progenitor cells into vascular lesions by promoting integrin-mediated adhesion and transmigration. Circulation Res 103 5 (2008) 536-544
25. Lisy M.R., Goermar A., Thomas C., et al. In vivo near-infrared fluorescence imaging of carcinoembryonic antigen-expressing tumor cells in mice. Radiology 247 3 (2008) 779-787
26. Zaheer A., Lenkinski R.E., Mahmood A., et al. In vivo near-infrared fluorescence imaging of osteoblastic activity. Nat Biotechnol 19 12 (2001) 1148-1154
27. Tung C.H., Mahmood U., Bredow S., and Weissleder R. In vivo imaging of proteolytic enzyme activity using a novel molecular reporter. Cancer Res 60 17 (2000) 4953-4958
28. Ma G., Gallant P., and McIntosh L. Sensitivity characterization of a time-domain fluorescence imager: eXplore Optix. Appl Opt 46 10 (2007) 1650-1657
29. McCormack E., Micklem D.R., Pindard L.E., et al. In vivo optical imaging of acute myeloid leukemia by green fluorescent protein: time-domain autofluorescence decoupling, fluorophore quantification, and localization. Mol Imaging 6 (2007) 193-204
30. Ntziachristos V., Ripoll J., Wang L.V., and Weissleder R. Looking and listening to light: the evolution of whole-body photonic imaging. Nat Biotechnol 23 3 (2005) 313-320
31. Dullin C, Zientkowska M, Missbach-Guentner J, et al. Semi-automatic landmark-based 2D-3D image fusion in living mice: Correlation of near-infrared fluorescence imaging of Cy5.5 labeled antibodies with flat-panel volume computed tomography. Mol Imaging 2009, in press.
32. Weissleder R., Tung C.H., Mahmood U., and Bogdanov Jr. A. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol 17 4 (1999) 375-378
33. Jain M., and Batra S.K. Genetically engineered antibody fragments and PET imaging: a new era of radioimmunodiagnosis. J Nucl Med 44 12 (2003) 1970-1972
34. Somville J., De Beuckeleer L., De Schepper A., et al. Reliability of measuring volume by different methods for tumors of the musculoskeletal system. Acta Orthop Belg 67 4 (2001) 338-343
35. Dullin C., Missbach-Guentner J., Vogel W.F., et al. Semi-automatic classification of skeletal morphology in genetically altered mice using flat-panel volume computed tomography. PLoS Genet 3 7 (2007) e118
36. Missbach-Guentner J., Dullin C., Zientkowska M., et al. Flat-panel detector-based volume computed tomography: a novel 3D imaging technique to monitor osteolytic bone lesions in a mouse tumor metastasis model. Neoplasia 9 9 (2007) 755-765
37. Missbach-Guentner J., Dullin C., Kimmina S., et al. Morphological changes of mammary carcinomas in mice over time as monitored by Flat-Panel Detector Volume Computed Tomography. Neoplasia 10 7 (2008) 663-673
38. Pickhardt P.J., Halberg R.B., Taylor A.J., et al. Microcomputed tomography colonography for polyp detection in an in vivo mouse tumor model. Proc NatI Acad Sci USA 102 9 (2005) 3419-3422
39. Krneta J., Kroll J., Alves F., et al. Dissociation of angiogenesis and tumorigenesis in follistatin- and activin-expressing tumors. Cancer Res 66 11 (2006) 5686-5695